Article
Pharmacology & Pharmacy
Young Yun Jung, Jae-Young Um, Arunachalam Chinnathambi, Chandramohan Govindasamy, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of Withaferin A (WFA) on apoptosis and autophagy in human colorectal cancer cells. The results showed that WFA could induce cell cycle arrest, increase apoptotic cell death, and activate autophagy. The WFA-induced effects on apoptosis and autophagy were mediated through the modulation of the beta-catenin pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Yinu Wang, Guangyuan Zhao, Salvatore Condello, Hao Huang, Horacio Cardenas, Edward J. Tanner, JianJun Wei, Yanrong Ji, Junjie Li, Yuying Tan, Ramana V. Davuluri, Marcus E. Peter, Ji-Xin Cheng, Daniela Matei
Summary: The study identifies platinum-tolerant cancer cells with cancer stem cell features characterized by expression of FZD7 and dependency on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival. These cells are highly susceptible to ferroptosis, marking a novel therapeutic vulnerability in platinum-resistant cancer cells.
Review
Chemistry, Medicinal
Cristina Trejo-Solis, Angel Escamilla-Ramirez, Dolores Jimenez-Farfan, Rosa Angelica Castillo-Rodriguez, Athenea Flores-Najera, Arturo Cruz-Salgado
Summary: The Wnt/β-catenin signaling pathway plays crucial roles in various cancer types, affecting cell survival, proliferation, angiogenesis, migration, invasion, metastasis, and stem cell renewal. However, the pathway can have dual effects, promoting both cell proliferation and apoptosis depending on the cellular context. Understanding the mechanisms behind these effects could lead to new therapeutic opportunities in cancer treatment.
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Article
Medicine, Research & Experimental
Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng
Summary: The study reveals that KAT6A is upregulated in ovarian cancer and correlates with patient survival. Downregulation of KAT6A inhibits proliferation and migration of ovarian cancer cells, induces apoptosis, and enhances sensitivity to cisplatin. Additionally, KAT6A interaction with COP1 leads to impaired function, accumulation, and enhanced activity of beta-catenin, suggesting a critical role of the KAT6A/COP1/beta-catenin signaling axis in ovarian cancer progression. Targeting this signaling axis could be a novel strategy for ovarian cancer treatment.
Article
Oncology
Yuanyuan Li, Han Lei, Rihan Hai, Guang Shu, Wenguang Yan, Gang Yin
Summary: This study found that HOXC10 is upregulated in ovarian cancer and is associated with carboplatin resistance. Further investigation revealed that HOXC10 can promote the expression of ABCC3 by upregulating beta-catenin, resulting in decreased sensitivity of cells to carboplatin. These findings suggest that the expression of HOXC10/ABCC3 could serve as a novel biomarker for predicting carboplatin resistance and prognosis in ovarian cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ding-Xi Liu, Shuang-Li Hao, Wan-Xi Yang
Summary: This study investigates the mechanism of maintaining balance between cell adhesion and signal regulation by focusing on the role of β-CATENIN. The study deepens the understanding of the Wnt/β-CATENIN signaling pathway through exploring β-CATENIN chaperone molecules, phosphorylation, epithelial mesenchymal transition, and their connection to disease.
DNA AND CELL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Devesh Tewari, Sweta Bawari, Shikha Sharma, Lindsay K. DeLiberto, Anupam Bishayee
Summary: Inflammation is a critical component of tumor promotion and progression, with the tumor microenvironment largely orchestrated by inflammatory cells. The Wnt/β-catenin signaling pathway plays a major role in cancer development and progression, with anti-inflammatory compounds targeting this pathway for cancer prevention and intervention.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Biochemistry & Molecular Biology
Fan Zhang, Pan Li, Shuang Liu, Mingqiang Yang, Shanshan Zeng, Junjian Deng, Danyang Chen, Yanmei Yi, Hao Liu
Summary: Breast cancer is the most common cancer among women worldwide, and while advancements have improved survival rates, metastasis remains a major obstacle. Breast cancer stem cells play a key role in metastasis and recurrence. Targeting the beta-Catenin/CCL2 signaling pathway may be an effective strategy for breast cancer therapy, as shown in this study's findings.
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Article
Plant Sciences
Ge Wang, Lu Li, Yan Li, Li-Hong Zhang
Summary: This study aimed to investigate the effects of toosendanin (TSN) on cisplatin (DDP) resistance in ovarian cancer (OC) and explore the underlying molecular mechanism. The results showed that TSN could reduce the DDP resistance in OC by modulating the miR-195/ERK/beta-catenin pathway, suggesting its potential as an effective agent to overcome clinical DDP resistance in OC.
Article
Reproductive Biology
Wenjing Hu, Min Li, Youguo Chen, Xinxian Gu
Summary: The research revealed that high expression of UBE2S in HGSOC is associated with poor prognosis. UBE2S promotes proliferation, migration, and invasion of ovarian cancer, and increases Olaparib resistance by activating the Wnt/β-catenin signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Yanhui Si, Lei Li, Weiwei Zhang, Qiling Liu, Baochi Liu
Summary: The study found that GANT61 effectively eliminates cancer cells and CSCs in colorectal cancer by blocking the Wnt/beta-catenin and Notch signaling pathways.