Review
Biotechnology & Applied Microbiology
Arundhathi Dev, Meenakshi Vachher, Chandra Prakash Prasad
Summary: beta-catenin is a crucial protein involved in various cellular processes, including cellular homeostasis, embryonic development, and cancer. It functions as a signaling molecule and also plays a role in cell adhesion. Aberrant expression of beta-catenin promotes the transcription of oncogenes and contributes to tumorigenesis. Understanding the regulation of beta-catenin is important for understanding the mechanisms of cancer progression.
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Sara A. Seifeldin, Khalid Alshaghdali, Samra Siddiqui, Mohamed Elfatih Abdelwadoud, Manish Vyas, Mohd Saeed, Avijit Mazumder, Amir Saeed
Summary: The Wnt pathway is crucial for human development and homeostasis. Dysregulation of this pathway has been linked to cancer. Wnt signaling plays a significant role in the development and metastasis of cancer, and targeting this pathway has become an important focus of cancer research. Flavonoids derived from plants have shown anticancer effects by influencing the Wnt pathway and other signaling pathways. This review comprehensively evaluates the impact of flavonoids on cancer development and metastasis through the Wnt pathway, providing evidence of their impact on molecular targets.
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Review
Pharmacology & Pharmacy
Xuetong Shen, Chundi Gao, Huayao Li, Cun Liu, Longyun Wang, Ye Li, Ruijuan Liu, Changgang Sun, Jing Zhuang
Summary: The abnormal activation of the Wnt/beta-catenin pathway is closely related to lung cancer progression and treatment resistance. Targeting this pathway shows potential for lung cancer therapy, but it is challenging due to its complexity and tumor heterogeneity. Natural products and derivatives have been found to inhibit the Wnt pathway and show promising anti-tumor efficacy. They could be a safer and more targeted alternative for lung cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biology
Dong Wook Shin
Summary: Hair loss, a common dermatological disorder, significantly impacts psychological well-being and quality of life. Although drug-based therapeutics are available, their limitations due to side effects are an issue. Recent research has identified the essential role of the Wnt/β-catenin signaling pathway in hair growth, with various natural products promoting hair growth by activating this signaling pathway.
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Article
Medicine, Research & Experimental
Wei Zhang, Xianhui Ruan, Yaoshuang Li, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianle Shi, Xin Wang, Jinpeng Wang, Weike Ma, Pengfei Gu, Xiangqian Zheng, Ming Gao
Summary: The study reveals that KDM1A regulates the stemness of thyroid cancer and promotes cancer progression through the Wnt/beta-catenin pathway. Inhibiting KDM1A can significantly inhibit thyroid cancer progression and enhance sensitivity to chemotherapy.
Article
Pharmacology & Pharmacy
Huifang Yin, Guanhong Xue, Ailing Dai, Haichong Wu
Summary: Lentinan exerts anti-inflammatory effects on LPS-induced mastitis by inhibiting the activation of the Wnt/beta-catenin pathway, suggesting its potential as a treatment for mastitis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wenyu Wang, Untack Cho, Anna Yoo, Chae-Lim Jung, Boyun Kim, Heeyeon Kim, Juwon Lee, HyunA Jo, Youngjin Han, Myoung-Hyun Song, Ja-Oh Lee, Se Ik Kim, Maria Lee, Ja-Lok Ku, Cheol Lee, Yong Sang Song
Summary: This study provides the first evidence for the anti-tumor effect of CWP232291 in ovarian cancer and suggests the inhibition of the Wnt/beta-catenin pathway as a novel therapeutic strategy against ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Jingmei Liu, Wei Yan, Ping Han, Dean Tian
Summary: KIAA1199, also known as CEMIP or HYBID, is an important oncogene associated with tumor progression and metastasis in various malignancies. It plays crucial roles in regulating multiple signaling pathways and could be a potential therapeutic target for cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Larissa Naomi Takeda, Lucas Fornari Laurindo, Elen Landgraf Guiguer, Anupam Bishayee, Adriano Cressoni Araujo, Lara Cristina Casadei Ubeda, Ricardo de Alvares Goulart, Sandra Maria Barbalho
Summary: Guava has medicinal properties that can be used in the treatment of various diseases and contribute to reducing the risk of chronic diseases. It also has economic importance for producing countries. The by-products of guava have potential applications in the food and cosmetic industries.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Harish Vancha, Devesh Tewari, Rajesh Kumar, Pilli Govindaiah, Sharfuddin Mohd, Sachin Kumar Singh, Monica Gulati
Summary: This study aimed to develop an analytical method for the estimation of xanthohumol (XH) in nanoformulations. A quality by design (QbD)-based UV-visible spectrophotometric method was developed and validated, which showed good linearity, accuracy, and precision. The developed method can be used for the estimation of XH in nanoformulations.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Oncology
Alisha Sachdeva, Dimple Dhawan, Gaurav K. Jain, Muekerrem Betuel Yerer, Taylor E. Collignon, Devesh Tewari, Anupam Bishayee
Summary: Oral cancer is a global cause of death, and traditional treatment methods face challenges of cancer recurrence and adverse reactions to chemotherapy drugs. Natural products play a significant role in drug discovery and have potential effects against various cancers, including oral cancer. The limited bioavailability of natural products is a major obstacle to their therapeutic application. Therefore, comprehensive utilization of various formulation strategies to improve bioavailability is important. This work presents recent advancements in novel strategies for natural product delivery that significantly enhance bioavailability and reduce adverse events in the prevention and treatment of oral cancer.
Review
Chemistry, Medicinal
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee
Summary: Cancer is a highly significant global health concern, and current treatment options, such as surgery, chemotherapy, radiation therapy, and immune therapy, have limitations and may lead to disease recurrence. Withaferin A, a natural bioactive compound found in the Indian medicinal plant Withania somnifera, has shown promising anticancer activities by modulating the expression and activity of oncogenic proteins. This article comprehensively discusses the biosynthesis, antineoplastic activities, mode-of-action, and clinical potential of withaferin A, as well as its effect on miRNA expression, combinational use with other cytotoxic agents, formulations, and safety profiles.
Review
Pathology
Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
Summary: About one-fourth of the global population is overweight or obese, increasing the risk of insulin resistance, cardiovascular diseases, and infections. Obesity is connected to the severity of COVID-19 and can lead to metabolic disorders. Diabetes is associated with persistent viral infections and affects vaccine effectiveness. Monitoring inflammatory and energy homeostasis markers is important in preventing obesity-related diseases.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Medicine, Legal
Sweta Kumari, Biplab Pal, Sanjeev Kumar Sahu, Pranav Kumar Prabhakar, Devesh Tewari
Summary: Clenbuterol, a potent beta-2 agonist, is widely misused by athletes, despite the lack of evidence for its performance-enhancing effects. This systematic review evaluated the adverse events associated with clenbuterol among athletes. 23 studies were included, and the most commonly occurring adverse events were cardiac-related complications.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Plant Sciences
Sweta Bawari, Archana N. Sah, Pawan Gupta, Gokhan Zengin, Devesh Tewari
Summary: This study aimed to establish the antiurolithiatic potential of Citrus jambhiri fruit juice and elucidate its mechanism of action. The results showed that the juice reduced nucleation, growth, and aggregation of calcium oxalate crystals, as well as improved various urinary parameters associated with urolithiasis in experimental rats. Docking studies revealed the binding potential of phytoconstituents in C. jambhiri with glycolate oxidase and matrix metalloproteinase-9. In conclusion, C. jambhiri fruit juice possesses excellent antiurolithiatic activity by restoring the equilibrium between stone formation promoters and inhibitors and inhibiting matrix metalloproteinases and glycolate oxidase.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maryam Ghanbari-Movahed, Sahar Shafiee, Jack T. Burcher, Ricardo Lagoa, Mohammad Hosein Farzaei, Anupam Bishayee
Summary: It has been found that cancer stem cells exhibit altered metabolism compared to non-CSCs, which plays a crucial role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Two natural flavonoids, apigenin and isovitexin, have been shown to enhance the efficacy of conventional chemotherapeutic drugs by sensitizing CSCs. This study aims to critically evaluate the potential of apigenin and isovitexin in targeting CSCs in different cancers as novel therapeutic agents.
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Tara Farhadi, Osman Hesami, Amin Iranpanah, Kassidy Webber, Anupam Bishayee
Summary: The tumor microenvironment (TME) plays a crucial role in cancer development and progression. The use of nanomedicine could be a promising approach to overcome barriers in tumor-targeted therapy. Nanoparticle formulations of natural compounds have shown potential in simultaneously targeting multiple dysregulated factors in TME and reducing tumor resistance mechanisms.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Leila Kooshki, Kassidy Webber, Anupam Bishayee
Summary: Tumor cells use multiple signaling mediators to escape hypoxia and promote angiogenesis and metastasis. HIF-1 plays a critical role in tumor conditions by stimulating target genes and dysregulated pathways in invasion and migration. Targeting the HIF-1 pathway and its cross-talk mediators may be a novel strategy for cancer prevention and treatment.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Food Science & Technology
Taylor E. Collignon, Kassidy Webber, Josh Piasecki, Austin S. W. Rahman, Arijit Mondal, Sandra Maria Barbalho, Anupam Bishayee
Summary: Avocado has shown anticancer properties and contains various phytochemicals that can induce cytotoxicity, reduce tumor size and volume, making it a potential option for cancer prevention and treatment. However, more research is needed before avocado-derived phytochemicals can be developed as cancer preventive agents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Vancha Harish, Sharfuddin Mohd, Devesh Tewari, Narendra Kumar Pandey, Sukriti Vishwas, Malakapogu Ravindra Babu, Mohamad Ayman Salkini, Zia Ur Rehman, Jehan Talaq Alotaibi, Renad Fahad Alotaibi, Fahad Abdulaziz Alrashed, Parteek Prasher, Nitin Sharma, Gaurav Gupta, Vikash Jakhmola, Yogendra Singh, Terezinha de Jesus Andreoli Pinto, Keshav Raj Paudel, Neeraj Mittal, Thakur Gurjeet Singh, Poonam Arora, Kamal Dua, Sachin Kumar Singh
Summary: In recent years, solid lipid nanoparticles (SLNs) have attracted significant research interest due to their ability to encapsulate drugs in their core, deliver drugs to specific targets, and protect drugs from the gastrointestinal environment. This review discusses the historical background and development of SLNs in nanotechnology. It also focuses on the composition, fabrication techniques, mechanism, and advantages of SLNs. The review highlights the biopharmaceutical aspects and challenges associated with the clinical translation of SLNs for improving the bioavailability, stability, and solubility of lipophilic and gastrointestinal labile drugs used in treating chronic diseases.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose Diogo E. Reis, Paulo Wender P. Gomes, Paulo R. da C. Sa, Sonia das G. S. R. Pamplona, Consuelo Yumiko Y. e Silva, Maria Fatima das G. F. da Silva, Anupam Bishayee, Milton Nascimento da Silva
Summary: This study identified new potential mass spectrometry signatures for phragmalin-type limonoids in Swietenia macrophylla leaves, providing valuable information for future drug development efforts.