FGF23 regulates atrial fibrosis in atrial fibrillation by mediating the STAT3 and SMAD3 pathways

Fibroblast growth factor 23 is induced by an activated renin–angiotensin–aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts

(2018) Maren Leifheit-Nestler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Lower soluble Klotho and higher fibroblast growth factor 23 serum levels are associated with episodes of atrial fibrillation

(2018) Katarzyna Mizia-Stec et al.   CYTOKINE

Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells

(2018) Rosalba Florio et al.   Scientific Reports

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

(2017) Edward R. Smith et al.   Scientific Reports

FGF23 promotes myocardial fibrosis in mice through activation of β-catenin

(2016) Huixin Hao et al.   Oncotarget

Fibroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes

(2016) Shih-Yu Huang et al.   Oncotarget

Association of Fibroblast Growth Factor 23 With Atrial Fibrillation in Chronic Kidney Disease, From the Chronic Renal Insufficiency Cohort Study

(2016) Rupal Mehta et al.   JAMA Cardiology

Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic MiceCLINICAL PERSPECTIVE

(2015) Anna Biernacka et al.   Circulation-Heart Failure

Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications

(2015) Dennis H. Lau et al.   EUROPEAN HEART JOURNAL

Cardiac Fibrosis in Patients With Atrial Fibrillation

(2015) Mikhail S. Dzeshka et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fibroblast Growth Factor-23 and Incident Atrial Fibrillation

(2014) Jehu S. Mathew et al.   CIRCULATION

Atrial Fibrillation: An Observational Study with Outpatients

(2014) GASTÓN ALBINA et al.   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

The epidemiology of atrial fibrillation in 
end-stage renal disease

(2013) Panagiotis Korantzopoulos et al.   JOURNAL OF NEPHROLOGY

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

(2012) Robert J. J. O'Donoghue et al.   EMBO Molecular Medicine

The origin of fibroblasts and mechanism of cardiac fibrosis

(2010) Guido Krenning et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY