Article
Biology
Yelena Y. Bernadskaya, Haicen Yue, Calina Copos, Lionel Christiaen, Alex Mogilner
Summary: The study found that the Ciona cardiopharyngeal progenitors are the simplest cell collective maintaining supracellular polarity, with differential distributions of protrusive forces, cell-matrix adhesion, and myosin-based retraction forces along the leader-trailer axis. Simulations and experiments suggest that cell-cell communication helps establish a hierarchy to align collective polarity with the direction of migration in three or more cells.
Article
Multidisciplinary Sciences
Chika Okimura, Misaki Iwanaga, Tatsunari Sakurai, Tasuku Ueno, Yasuteru Urano, Yoshiaki Iwadate
Summary: This study reveals that leading-edge elongation in collective cell migration is achieved through the insertion of follower cells. Follower cells and adjacent leader cells are connected by actomyosin cables, and the contractile forces along the cables transform follower cells into leaders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Dina J. Ashour, Clinton H. Durney, Vicente J. Planelles-Herrero, Tim J. Stevens, James J. Feng, Katja Roper
Summary: During embryogenesis, the coordination of large-scale changes in tissue primordia is important for development. In Drosophila, supracellular actomyosin cables, composed of the protein Zasp52, are involved in this coordination, particularly in regions such as the ventral midline and the boundary of the salivary gland placode. Zasp52 interacts with junctional components and actomyosin regulators, and its absence leads to severe embryonic defects. These findings suggest that Zasp52-containing cables aid in insulating morphogenetic changes from one another during embryogenesis.
Article
Cell Biology
Robert J. Huebner, Shinuo Weng, Chanjae Lee, Sena Sarikaya, Ophelia Papoulas, Rachael M. Cox, Edward M. Marcotte, John B. Wallingford
Summary: This article investigates the role of the Arvcf protein in controlling head-to-tail axis extension in Xenopus. It is found that Arvcf is necessary for axis extension in the intact organism, but not in isolated tissues. The study also reveals that the force defect is a result of the dampening of pulsatile recruitment of cell adhesion and cytoskeletal proteins.
DEVELOPMENTAL CELL
(2022)
Article
Engineering, Biomedical
Haihui Zhang, Hongwei Xu, Weihao Sun, Xu Fang, Peiwu Qin, Jianyong Huang, Jing Fang, Feng Lin, Chunyang Xiong
Summary: Mechanical heterogeneity plays an important role in mediating collective cell migration. By fabricating microelastically-patterned hydrogels with varying periodic distance, it was observed that a decrease in periodic distance leads to increased velocity and directionality of migrating cells. Inhibition of ROCK and myosin IIA contraction reduces cell migration on mechanically heterogeneous substrates. F-actin and myosin IIA form purse-string structures at the leading edge on mechanically heterogeneous substrates, revealing their involvement in cell-cell interactions and mechanical perception.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Anna Popkova, Matteo Rauzi, Xiaobo Wang
Summary: Tissue elongation is driven by tissue rotation and actomyosin contractions in Drosophila egg chamber, where supracellular networks constrain egg growth in a polarized manner. Both cellular and supracellular planar polarity play critical roles in controlling tissue extension.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Emma Lang, Christian Pedersen, Anna Lang, Pernille Blicher, Arne Klungland, Andreas Carlson, Stig Ove Boe
Summary: The study reveals that quiescent cell monolayers are mechanically prepared for movement upon exit from quiescence, and amplification of global stress serves as a mechanism to overcome motility restrictions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physics, Multidisciplinary
Amit Das, Srikanth Sastry, Dapeng Bi
Summary: Cell neighbor exchanges play a crucial role in tissue rearrangements in biology, but these processes are rate limited in biological tissues compared to nonliving materials. This study shows how this time constraint affects the mechanics and collective behavior of cells in a tissue, leading to the development of spatially correlated populations of fast and slow cells. The predictions of this work are validated by existing in vivo experiments in Drosophila pupal development.
Article
Biochemistry & Molecular Biology
Jose Casal, Freya Storer, Peter A. Lawrence
Summary: Planar cell polarity (PCP) relies on at least two molecular systems, each utilizing a supracellular concentration gradient. This study investigates the distribution of the Frizzled receptor in living pupal abdomen of Drosophila, revealing a supracellular gradient that resets in the next segment. Furthermore, an intracellular asymmetry in Frizzled distribution is observed, suggesting independent actions of the PCP systems.
Article
Engineering, Biomedical
Patricia Costa, Liisa M. Blowes, Ana C. Laly, John T. Connelly
Summary: The study demonstrates that adhesive cues from the extracellular matrix guide collective epithelial polarity and migration, depending on adherens junctions and microtubules. Disruption of the microtubule network blocks collective polarization and inhibits directed migration of epithelial cells according to pre-established polarity.
ACTA BIOMATERIALIA
(2021)
Article
Cell Biology
Shinuo Weng, Robert J. Huebner, John B. Wallingford
Summary: Convergent extension is an evolutionarily conserved cell movement that elongates organ systems. Studies have shown that cell crawling and junction contraction are two distinct cellular mechanisms, and integrating these two modes via mechano-reciprocity can enhance the effectiveness of CE.
Article
Materials Science, Multidisciplinary
Shinya Sakakibara, Shimaa A. A. Abdellatef, Shota Yamamoto, Masao Kamimura, Jun Nakanishi
Summary: By using photoactivatable surfaces, researchers successfully induced collective migration in cell clusters in an inverted position against gravity, revealing the influence of the gravity vector on collective cell migration. The inversion of cells against gravity resulted in cytoskeletal remodeling and strengthening of actin bundles, which affected the migration phenotypes of cell clusters. This study provides important insights into the impact of gravity on human health during space travel.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2023)
Article
Cell Biology
Lowell T. Edgar, Hyojin Park, Jessica R. Crawshaw, James M. Osborne, Anne Eichmann, Miguel O. Bernabeu
Summary: Angiogenesis involves the phases of spouting and remodelling, and abnormal remodelling can result in vascular malformation. The dysfunction of cell-cell adherens junctions is implicated in vascular disease and arteriovenous malformations (AVMs). Cell polarity mixture and excessive cell-cell cohesion disrupt cell migration and blood flow.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Adria Chorro, Bhavna Verma, Maylin Homfeldt, Beatriz Ibanez, Peter A. Lawrence, Jose Casal
Summary: This study demonstrates and measures the supracellular molecular gradient of Dachsous (Ds), a conserved molecule involved in planar cell polarity (PCP), in the cell membranes of the Drosophila abdomen. The findings show that the gradient rises from the head to tail in the anterior compartment and falls in the posterior compartment. The loss of Four-jointed (Fj) reduces intracellular asymmetry, leading to decreased robustness of PCP.
Article
Biochemistry & Molecular Biology
Karl H. Palmquist, Sydney F. Tiemann, Farrah L. Ezzeddine, Sichen Yang, Charlotte R. Pfeifer, Anna Erzberger, Alan R. Rodrigues, Amy E. Shyer
Summary: During vertebrate embryogenesis, cell collectives engage in coordinated behavior to form tissue structures of increasing complexity. The initiation of follicle patterning in avian skin is initiated by the mechanical rearrangement of extracellular matrix (ECM) by contractile cells, which further aligns the cells and transforms them into a continuum with coherent, long-range order. This ordered cell-ECM layer behaves as an active contractile fluid and spontaneously forms regular patterns, illustrating the role of mesenchymal dynamics in generating cell-level ordering and tissue-level patterning.
Article
Biochemical Research Methods
Andras Szabo, Eric Theveneau, Melissa Turan, Roberto Mayor
PLOS COMPUTATIONAL BIOLOGY
(2019)
Review
Cell Biology
Adam Shellard, Roberto Mayor
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2019)
Article
Multidisciplinary Sciences
Dirk Ollech, Tim Pflaesterer, Adam Shellard, Chiara Zambarda, Joachim Pius Spatz, Philippe Marcq, Roberto Mayor, Richard Wombacher, Elisabetta Ada Cavalcanti-Adam
NATURE COMMUNICATIONS
(2020)
Correction
Multidisciplinary Sciences
Dirk Ollech, Tim Pflasterer, Adam Shellard, Chiara Zambarda, Joachim Pius Spatz, Philippe Marcq, Roberto Mayor, Richard Wombacher, Elisabetta Ada Cavalcanti-Adam
NATURE COMMUNICATIONS
(2020)
Review
Biology
Adam Shellard, Roberto Mayor
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Developmental Biology
Brenda Canales Coutino, Roberto Mayor
Summary: This study reveals that neural crest cells require a tight regulation of Rac1 by Semaphorins and Piezo1 for directional migration in vivo. The balance between a myriad of signals through Rac1 dictates cell migration in vivo, which is likely to be conserved in other cell migration processes.
Correction
Multidisciplinary Sciences
Adam Shellard, Roberto Mayor
Article
Multidisciplinary Sciences
Adam Shellard, Roberto Mayor
Summary: The neural crest uses durotaxis to follow stiffness gradients in adjacent placodal tissue, contributing to efficient collective cell migration. Durotaxis synergizes with chemotaxis to polarize actomyosin machinery of the cell group, promoting efficient directional cell migration in vivo.
Article
Developmental Biology
Elias H. Barriga, Delan N. Alasaadi, Chiara Mencarelli, Roberto Mayor, Franck Pichaud
Summary: This study reveals the essential role of RanBP1 in neural crest cell collective migration, which is involved in establishing front-to-rear polarity and promoting directed chemotaxis. This finding has important implications for our understanding of cell migration and various pathological conditions.
DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Namid R. Stillman, Roberto Mayor
Summary: Understanding the mechanisms of cell coordination in differentiation and migration is crucial for comprehending wound healing, disease progression, and developmental biology. Mathematical models have played an essential role in testing and improving our understanding, including the models of cells as soft spherical particles, reaction-diffusion systems linking cell movement to environmental factors, and multi-scale multi-physics simulations combining rule-based models with continuum laws. However, mathematical models often lack strong data relation or have excessive parameters, leading to weakly constrained model behavior. Recent advancements in machine learning provide new approaches for model derivation and deployment. This review explores examples of mathematical models in developmental biology, such as cell migration, and how these models can be integrated with recent machine learning methods.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lucas Alvizi, Diogo Nani, Luciano Abreu Brito, Gerson Shigeru Kobayashi, Maria Rita Passos-Bueno, Roberto Mayor
Summary: This study explores the gene-environment interaction in cleft lip and palate (CLP) by investigating CDH1/E-Cadherin variants and pro-inflammatory conditions. They propose a two-hit model for CLP development, where impaired neural crest migration is caused by a combination of genetic and environmental factors. The authors also demonstrate that CDH1 hypermethylation is a major target of the pro-inflammatory response, regulating E-cadherin levels and neural crest migration.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Hoang Anh Le, Roberto Mayor
Summary: This article discusses the regulatory role of physical properties of tissue, especially cell migration, emphasizing the contribution from cellular components and the impact of stiffness and topology on cell-cell interactions.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)