Article
Materials Science, Multidisciplinary
Diana Maria Vranceanu, Elena Ungureanu, Ionut Cornel Ionescu, Anca Constantina Parau, Adrian Emil Kiss, Alina Vladescu, Cosmin Mihai Cotrut
Summary: The current research aims to biofunctionalize pure titanium substrate with titania nanotubes and Zn doped hydroxyapatite-based coatings. The addition of Zn enhances the properties of hydroxyapatite, and the concentration of Zn can be modulated to achieve coatings with tunable features.
Article
Microbiology
Aliaa Abdelghafar, Nehal Yousef, Momen Askoura
Summary: This study investigated the influence of zinc oxide nanoparticles (ZnO-NPs) on the susceptibility and pathogenesis of Staphylococcus aureus. The results showed that ZnO-NPs exhibited a good antibiofilm activity against S. aureus and had a synergistic effect when combined with antibiotics. ZnO-NPs were able to decrease the surface hydrophobicity of S. aureus cells and reduce bacterial biofilm formation. Furthermore, ZnO-NPs-treated bacteria showed decreased blood hemolysis and repression of biofilm-related genes. In a mice infection model, ZnO-NPs accelerated wound healing compared to untreated mice.
Review
Biochemistry & Molecular Biology
Denis Swolana, Robert D. Wojtyczka
Summary: The article introduces the effects of Staphylococcus epidermidis and Staphylococcus aureus on human health, as well as silver nanoparticles as a potential new substance for neutralizing bacterial cells. By reviewing the data on the activity of silver nanoparticles in inhibiting bacterial growth and biofilm formation, it provides insights for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Wei Yuan, Yixuan Wei, Yongli Zhang, Luqman Riaz, Qingxiang Yang, Qiang Wang, Ruifei Wang
Summary: The study shows that multidrug-resistant E. coli LM13 can counteract the antibacterial activities of TiO2 and ZnO NPs through an efflux pump and other regulatory genes, while also exhibiting higher resistance to NPs compared to susceptible E. coli strain ATCC25922. Additionally, the research demonstrates that the intensity of side-scatter light parameter increases with TiO2 and ZnO NPs in a dose-dependent manner, indicating NP uptake by both strains.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Materials Science, Multidisciplinary
Esensil Man Hia, Bikendra Maharjan, Chan Hee Park, Cheol Sang Kim
Summary: In this study, polydopamine-coated zinc oxide (ZnO) nanoparticles were integrated with hydroxyapatite (HAp) to obtain HAp@ZnO/PDA composite nanoparticles. The results showed that these composite nanoparticles exhibited effective antibacterial properties and enhanced cytocompatibility.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Gehan T. El-Bassyouni, Sayed H. Kenawy, Abeer A. Abd El-Aty, Esmat M. A. Hamzawy, Gamal M. Turky
Summary: This study investigated the biocompatibility, antimicrobial activity, and dielectric properties of hydroxyapatite (HA) doped with different percentages of zinc oxide (ZnO). The results showed that the addition of ZnO did not affect the formation of hydroxyapatite. Biocompatibility testing in simulated body fluid (SBF) revealed the formation of a new HA layer on the soaked samples. Antimicrobial and antifungal testing demonstrated that incorporating ZnO enhanced the antimicrobial effects. Dielectric measurements showed that increasing ZnO content decreased conductivity due to increased interfacial polarization. Moreover, antibacterial action expanded in the inhibition zones with increasing zinc concentrations. Dielectric relaxation spectroscopy revealed that the dielectric spectra were characterized by a combination of interfacial polarization and conductivity contribution at low and intermediate frequencies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Analytical
Rui Liu, Suleiman A. Haruna, Shujat Ali, Jing Xu, Yunlian Zhang, Peng Lu, Huanhuan Li, Quansheng Chen
Summary: A fluorescent genosensor was developed for Staphylococcus aureus detection, utilizing interactions between specific single-stranded DNA and graphene oxide quantum dots for sensitive detection. The sensor exhibited high sensitivity with a LOD of 0.98 x 10(-17) mol L-1 and was successfully applied for real sample analysis. Additionally, the sensor could be adapted for the detection of other pathogens by replacing recognition probes and primers.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Environmental Sciences
Guy Didier Fanou, Mamadou Traore, Benjamin Kouassi Yao, Andrei Kanaev, Khay Chhor
Summary: A new composite photocatalyst was developed by grafting size-selected 5-nm titanium-oxo-alkoxo nanoparticles onto P25-TiO2 nanoparticles and incorporating HAP obtained by co-precipitation of salts. The photocatalytic yield was increased for the composite photocatalysts with the addition of HAP, likely due to a synergy between adsorption and photo-oxidation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Polymer Science
Jennifer Balcucho, Diana M. Narvaez, Natalia A. Tarazona, Jinneth Lorena Castro-Mayorga
Summary: Antimicrobial resistance is a major global health threat. In this study, bio-based silver and copper oxide nanoparticles were combined with a microbial-produced polyester to create bioactive films for the prevention and treatment of MRSA infections. These films showed strong antibacterial activity against MRSA and did not induce significant cytotoxicity or DNA damage in human fibroblast cells. These films also promoted platelet aggregation, which is beneficial for wound healing.
Article
Chemistry, Physical
Pinar Sen, Tebello Nyokong
Summary: In this study, Schiff base substituted neutral phthalocyanines derived from aldehyde substituted phthalocyanine were conjugated to silver nanoparticles through strong interactions. The photophysicochemical properties and photodynamic antimicrobial chemotherapy activities of the nanoconjugates were investigated, showing excellent antimicrobial activity with 100% reduction against Staphylococcus aureus.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Environmental Sciences
Shoaib Ahmad, Manar Fawzi Bani Mfarrej, Mohamed A. El-Esawi, Muhammad Waseem, Aishah Alatawi, Muhammad Nafees, Muhammad Hamzah Saleem, Muhammad Rizwan, Tahira Yasmeen, Alia Anayat, Shafaqat Ali
Summary: This study investigates the use of microbe-assisted phytoremediation with zinc oxide nanoparticles for detoxification of chromium-contaminated soils. The results show that the combined application of bacterial inoculation and zinc oxide nanoparticles can reduce the toxicity of chromium on wheat plants and improve their growth and defense system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Microbiology
Rafael Bianchini Fulindi, Juliana Domingues Rodrigues, Thulio Wliandon Lemos Barbosa, Ariana Goncalves D. Garcia, Felipe de Almeida La Porta, Sebastiao Pratavieira, Leila Aparecida Chiavacci, Joao Pessoa Araujo Junior, Paulo Inacio da Costa, Luis R. R. Martinez
Summary: In this study, the bactericidal and antibiofilm activity of zinc oxide (ZnO) and zinc sulfide (ZnS) nanoparticles against medically important bacteria was analyzed for the first time. The results showed that ZnS and ZnO had similar efficacy in killing bacteria and reducing biofilm formation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Francesca Berini, Viviana Teresa Orlandi, Federica Gamberoni, Eleonora Martegani, Ilaria Armenia, Rosalba Gornati, Giovanni Bernardini, Flavia Marinelli
Summary: Conjugating antibiotics with nanoparticles can effectively prevent and combat infections caused by resistant bacteria, while reducing the side effects and spread of antibiotic resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Engineering, Biomedical
Matilde Concilio, Ramon Garcia Maset, Laia Pasquina Lemonche, Vito Kontrimas, Ji-Inn Song, Santhosh Kalash Rajendrakumar, Freya Harrison, C. Remzi Becer, Sebastien Perrier
Summary: Antimicrobial-resistant pathogens have become a significant global health concern, demanding the development of new treatments. Synthetic nanoengineered antimicrobial polymers (SNAPs) show promise as an alternative to antimicrobial peptides, with high activity against Staphylococcus aureus and good biocompatibility. The lead compounds disrupt the cell membrane of S. aureus, while leaving the cell wall unaffected. In addition, there is a potential interaction of the compounds with bacterial DNA, suggesting implications on bacterial division. Finally, one of the compounds exhibits high efficacy in vivo in an insect infection model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Urvashi F. Gunputh, Huirong Le, Kiruthika Lawton, Alexandros Besinis, Christopher Tredwin, Richard D. Handy
Article
Mechanics
George Z. Voyiadjis, Reem Abo Znemah, Paul Wood, Urvashi Gunputh, Cheng Zhang
Summary: This study investigated the homogeneity and isotropy of the mechanical hardness of thin-walled Inconel 718 alloy samples manufactured by Selective Laser Melting (SLM) using nanoindentation testing. The results showed variations in hardness across different thicknesses and directions, with a proposed variable material length scale to describe the size effects of the microstructure.
MECHANICS RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
James Butler, Sean D. Kelly, Katie J. Muddiman, Alexandros Besinis, Mathew Upton
Summary: This study reports the characterization of a strain of C. pauculus isolated from a hospital sink trap and assesses its potential risk to human health. The findings show that the strain is multidrug-resistant and capable of biofilm formation.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
P. Wood, A. Rusinek, P. Platek, J. Janiszewski, J. Sienkiewicz, U. F. Gunputh, K. Rajkowski, M. H. Miguelez
Summary: This paper investigates the effect of a randomly dispersed spherically voided microstructure on tensile ductility, fracture, and fragmentation at high strain rate using Electromagnetic Ring Expansion Tests (ERET) on Laser Melting Powder Bed Fusion (LPBF) Inconel 718 stress relieved test pieces. An empirical model to predict porosity type and growth rates based on laser energy density was established to select LPBF process parameters. The study found a significant positive strain rate effect on tensile ductility at lower porosities.
MATERIALS & DESIGN
(2021)
Article
Engineering, Chemical
Marzena Pawlik, Lyddia Yi Yu Cheah, Urvashi Gunputh, Huirong Le, Paul Wood, Yiling Lu
Summary: This study investigates the effect of various surface modifications on the adhesive joint of CFRP. The results show that the highest shear strength is achieved by the metal mesh modified joints, which exhibit a significant improvement in bonding strength compared to acetone-cleaned specimens.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2022)
Article
Chemistry, Physical
Qingxin Wei, Yang Liu, Huirong Le
Summary: This study investigates the thermal resistance, mechanical properties, and phase evolution of geopolymer ceramics reinforced with mullite fibers. The addition of mullite fibers significantly improves the mechanical properties and promotes crack deflection and fiber pullout mechanisms. The study also discusses the interface bonding between mullite fibers and the geopolymer.
Article
Engineering, Manufacturing
Paul Wood, Fathi Boud, Wayne Carter, Hirbod Varasteh, Urvashi Gunputh, Marzena Pawlik, Jenny Clementson, Yiling Lu, Syed Hossain, Matthew Broderick, Munusamy Raguraman, Andy Smith, Andy Mantle, Jamie McGourlay
Summary: This paper discusses a method of instrumented tapping test using a CNC machine tool to compare the lubricity of metalworking fluids (MWFs) in cutting titanium alloy. The method incorporates a soft synchronous tap holder and spindle mounted dynamometer to measure torque and thrust force, and is demonstrated on three commercially available groups of MWFs. The results show that the fully synthetic group displays the best lubricity, with the fully synthetic from renewables (FS-bio) being the best overall within this group.
JOURNAL OF MANUFACTURING AND MATERIALS PROCESSING
(2022)
Review
Chemistry, Multidisciplinary
James Butler, Richard D. Handy, Mathew Upton, Alexandros Besinis
Summary: This review discusses the development of antimicrobial nanocoatings for medical and dental applications. Nanomaterials can reduce bacterial growth and prevent biofilm formation through biochemical reactions, reactive oxygen species production, or physical damage. Nanocoatings can contain metal nanoparticles like silver, copper, and gold, or carbon-based materials like graphene and carbon nanotubes. Surface nanotopography can also be modified to create a hostile environment for bacteria. Combining different nanomaterials can create nanocomposites with unique properties. However, concerns remain about toxicity, legal regulations, and bacterial resistance. Safe development of antimicrobial nanocoatings requires careful consideration and risk assessment.
Review
Materials Science, Multidisciplinary
Kaibao Wang, Huirong Le
Summary: This article reviews the current use of conventional coatings and evaluates the potential use of novel geopolymer coatings on metal substrates, particularly on steel structures. Traditional fireproofing systems have unavoidable limitations, while innovations in coatings are rapidly developing. Geopolymer coatings have attracted attention due to their higher mechanical strength and excellent resistance to chemicals and heat. Compared to cement-based coatings, geopolymer coatings offer superior mechanical and thermal performance with lower environmental impact, suggesting great potential for fire protection on steel structures.
Article
Immunology
Israa M. S. Al-Kadmy, Sarah Naji Aziz, Ahmed Mahdi Rheima, Suhad Abbas Abid, Ahmed Suhail, Israa Hussein Hamzah, Eman N. Naji, Alwxandros Besinis, Helal F. Hetta
Summary: This study aimed to detect the anti-capsular activity of CuO nanoparticles against Acinetobacter baumannii produce efflux pump. Results demonstrated that CuO nanoparticles have anti-capsular effect and show synergistic effect with gentamicin. Furthermore, the study found a relationship between capsule formation and the absence of biofilm formation in A. baumannii.
MICROBIAL PATHOGENESIS
(2023)
Article
Materials Science, Multidisciplinary
Paul Wood, Andrew Mantle, Fathi Boud, Wayne Carter, Urvashi Gunputh, Marzena Pawlik, Yiling Lu, Jose Diaz-Alvarez, Maria Henar Miguelez Garrido
Summary: This study discusses a comparison experiment between naturally aged and unaged metalworking fluids (MWF) to test their performance difference in machining Inconel 718 alloy. It is found that the higher total hardness of the aged MWF leads to reduced lubricity and accelerated flank wear.
Article
Crystallography
Paul Wood, Jose Diaz-Alvarez, Alexis Rusinek, Urvashi Gunputh, Slim Bahi, Antonio Diaz-Alvarez, Maria Henar Miguelez, Yiling Lu, Pawel Platek, Judyta Sienkiewicz
Summary: This study discusses the impact of microstructure on the machinability of Inconel 718 by conducting machining tests on two types of workpiece materials. The results show that grain structures significantly affect the machinability of the superalloy at higher feed rates, and the effectiveness of coolant as a lubricant in reducing friction during machining is also discussed.
Article
Multidisciplinary Sciences
Urvashi F. Gunputh, Gavin Williams, Adam Leighton, Wayne Carter, Hirbod Varasteh, Marzena Pawlik, Yiling Lu, Ruth Sims, Melinda Lyons, Jenny Clementson, Gyan Tripathi, Nick Chambers, Matt Roe, Paul Wood
Summary: During the COVID-19 pandemic, there was a shortage of certified personal protective equipment (PPE), leading to the use of non-certified PPE by healthcare staff. The University of Derby, along with a local NHS Trust and a small and medium enterprise, developed test protocols for PPE with a one-size-fits-all concept. The study identified key design parameters such as strap width and comfort level for a healthcare-related face shield. The findings will contribute to new standards in the design of PPE for diverse users.
Article
Materials Science, Composites
Hongwei Chen, Kaibao Wang, Yao Chen, Huirong Le
Summary: This paper evaluates the mechanical and thermal properties of 3D-printed short carbon fiber reinforced composites (sCFRPs). A numerical analysis was developed to predict the mechanical and thermal properties, which were verified via experimental tests. The effects of integrating various copper meshes with carbon fiber fabric on the mechanical and thermal properties of the composite plate were studied theoretically and experimentally.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Review
Materials Science, Composites
Urvashi F. Gunputh, Huirong Le
JOURNAL OF COMPOSITES SCIENCE
(2020)
