Article
Oncology
Pinar Sen, Tebello Nyokong
Summary: Antimicrobial resistance is a major challenge in infectious disease treatment. Antimicrobial photodynamic therapy using octa-imine substituted ZnPc conjugated to nitrogen, sulfur co-doped graphene quantum dots shows promising results in in vitro cell studies against Grampositive bacteria, particularly Staphylococcus aureus.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Chemistry, Physical
Pinar Sen, John Mack, Tebello Nyokong
Summary: In this study, a series of new tetra-substituted indium phthalocyanine (InPc) complexes were prepared and their photodynamic antimicrobial activities were evaluated. The results showed that one of the complexes, 4, exhibited high antimicrobial activity under specific conditions.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Kevser Harmandar, Mehmet F. Saglam, Ibrahim F. Sengul, Gulcin Ekineker, Pelin Balcik-Ercin, Meltem Goksel, Devrim Atilla
Summary: This study describes the simple and efficient synthesis of novel zinc(II) phthalocyanines bearing triazole moieties and investigates their potential in photodynamic therapy. The synthesized compounds showed promising characteristics as photosensitizers for tumor cells.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Aviwe Magadla, Balaji Babu, Pinar Sen, Tebello Nyokong
Summary: This study investigates the photodynamic activity of complexes encapsulated into silica nanoparticles and conjugated with folic acid. The results show that folic acid conjugates exhibit greater photocytoxicity against MCF-7 cells, indicating potential for photodynamic therapy applications.
Article
Chemistry, Physical
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: New tetra-substituted zinc and indium Schiff base phthalocyanines (ZnPc and InPc) were synthesized and characterized. Cationic derivatives of these Pcs were obtained by reacting ethyl pyrrolidine (ZnPc-2, InPc-2) and propyl pyrrolidine (ZnPc-3, InPc-3) substituted Schiff base Pcs with methyl iodide. The cationic Pcs exhibited higher singlet oxygen quantum yield in aqueous media and showed effective photoinactivation against Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA) strains, depending on the singlet oxygen ability, charges, and alkyl group extension.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Khaoula Khezami, Kevser Harmandar, Esra Bagda, Efkan Bagda, Gamze Sahin, Nursen Karakodak, Mahmut Durmus
Summary: In this study, two novel water-soluble zinc(II) phthalocyanines were synthesized and studied for their potential applications in photodynamic therapy. The interaction between these compounds and BSA or ct-DNA was investigated, with differences in binding constants observed between the two compounds. Thermal denaturation and viscosity studies indicated a non-intercalative mode of binding to ct-DNA for both compounds.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Nazli Farajzadeh, Cetin Celik, Goknur Yasa Atmaca, Sadin Ozdemir, Serpil Gonca, Ali Erdogmus, Makbule Burkut Kocak
Summary: This research presents a novel method for synthesizing phthalocyanines and their derivatives, with evaluation of their potential as photosensitizing materials for photodynamic antimicrobial therapy based on spectroscopic and biological activity assessments.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Sithi Mgidlana, Pinar Sen, Tebello Nyokong
Summary: Synthetic compounds of asymmetric (A3B) Zn(II) phthalocyanines with dimethoxy phenoxy as the main substituent and (phenoxy) propanoic acid, (phenoxy) acetic acid, and (phenoxy) acrylic acid as other substituents were linked to silver tungstate nanoparticles. The photocatalytic and photodynamic antimicrobial chemotherapy activities of these compounds were evaluated for the degradation of tetracycline and inactivation of S. aureus under visible light irradiation. The results showed that compound 3 exhibited the best performance, attributed to its higher singlet oxygen quantum yield. The mechanism of singlet oxygen generation under visible light was confirmed using EPR. Furthermore, the photoinactivation of S. aureus was enhanced in the presence of tetracycline.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Andrea Sowa, Alexander Hoeing, Ulrich Dobrindt, Shirley K. Knauer, Anzhela Galstyan, Jens Voskuhl
Summary: This study describes the synthesis, characterization, and application of water-soluble zinc(II) phthalocyanines decorated with umbelliferone moieties for photodynamic therapy. These compounds exhibited excellent phototoxicity and antimicrobial activity in cells and bacteria, making them promising photosensitizers for future broad applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Polymer Science
Xiaoling Xu, Tianheng Wang, Die Li, Chunyang Bao, Yan Wang, Jingyu Zhang, Bin Peng, Mei Hong, Jing Chen, Qiang Zhang
Summary: Tripodal heptadentate amine ligands, Py3H3Tren and Py3Me3Tren, were used for atom transfer radical polymerization (ATRP). The coordination between the ligands and CuBr2 was investigated using electrospray ionization mass spectrometry, and tripod claw-shaped complexes were found. CuBr2/Py3H3Tren showed a more negative redox potential and higher reactivity. The order of KATRP of CuBr2/ligand was Py3H3Tren > Py3Me3Tren > Py3Tren. CuBr2/Py3H3Tren and CuBr2/Py3Me3Tren were used as catalysts for the ATRP of MA, producing well-defined polymers with controlled molecular weight. CuBr2/Py3Me3Tren showed the fastest reaction rate. Photo-induced ATRP using Py3H3Tren and Py3Me3Tren as ligands was also performed, with Py3H3Tren showing the fastest reaction rate and Py3Me3Tren producing polymers with lower polydispersity.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Igor Santos Oliveira, Carlos Marrote Manzano, Douglas Hideki Nakahata, Mariana Brentini Santiago, Nagela Bernadelli Sousa Silva, Carlos Henrique Gomes Martins, Fernando Pimentel Respindula, Douglas Henrique Pereira, Pedro Paulo Corbi
Summary: Skin wound infections are a common cause of death in burned patients. The emergence of multidrug resistant microorganisms has complicated the treatment of these infections, necessitating the development of novel antimicrobial agents. In this study, a new silver complex AgSFX-SL was synthesized and shown to have effective antimicrobial and antifungal activities against various pathogens.
Article
Optics
Yolande Ikala Openda, Sithi Mgidlana, Tebello Nyokong
Summary: A novel nano-photosensitizer was developed by linking an asymmetrical zinc (II) phthalocyanine with glutathione capped graphene quantum dots, showing higher photocatalytic activity and antimicrobial effect against drug-resistant bacteria strains.
JOURNAL OF LUMINESCENCE
(2022)
Article
Oncology
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: Antimicrobial photodynamic inactivation (aPDI) is an effective method for eradicating drug-resistant microorganisms due to its minimal possibility of microbial resistance. This study focuses on the preparation and characterization of novel neutral and cationic morpholine containing Schiff base phthalocyanines. The cationic complexes show promising photodynamic activity against various microorganisms, while the neutral complexes are not suitable for antimicrobial studies. The effectiveness of aPDI is dependent on the concentration and light dose.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Milan Kumar Mandal, Swagatika Ghosh, Lieve Naesens, Hans Raj Bhat, Udaya Pratap Singh
Summary: The study involved the synthesis of novel compounds with significant antimicrobial and antiviral activities, particularly showing strong inhibitory effects against bacteria and fungi, as well as considerable antiviral activity against various viruses. The findings suggest potential for the development of compounds with dual antimicrobial and antiviral properties.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
L. Collen Makola, Tebello Nyokong, Edith K. Amuhaya
Summary: Photodynamic antimicrobial chemotherapy (PACT) is an effective technique against antibiotic-resistant bacteria. In this study, novel porphyrin complexes with high PACT activity were synthesized and linked to nanoparticles through self-assembly, resulting in efficient eradication of Staphylococcus aureus.
Article
Chemistry, Analytical
Mbulelo Jokazi, Lekhetho S. Mpeta, Tebello Nyokong
Summary: Manganese and cobalt metalated porphyrins attached to graphene quantum dots showed improved electrocatalytic activity for the oxidation of hydrazine, with CoTA(3)CPP-GQDs exhibiting the best catalytic rate constants and lowest limits of detection.
Article
Biochemistry & Molecular Biology
Pinar Sen, Azole Sindelo, Nnaemeka Nnaji, John Mack, Tebello Nyokong
Summary: Novel mono- and dipyridylvinyl boron dipyrromethene dyes were prepared and compared to the corresponding core dyes for their photodynamic antimicrobial chemotherapy (PACT) activities. Results showed that the spectral properties of the dyes and the generation of singlet oxygen could be controlled through pyridylvinyl substitution and iodine atom incorporation, but the pi-extended dyes had lower activities compared to the core dye.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Oncology
Yolande Ikala Openda, Tebello Nyokong
Summary: Photodynamic antimicrobial chemotherapy (PACT) combined with ciprofloxacin (CIP) effectively reduces the biofilm cell survival of antibiotic-resistant S. aureus and E. coli strains. PACT alone shows no significant activity, while CIP alone exhibits some inhibitory activity. The combination treatment completely eradicates mature biofilms.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lindokuhle Cindy Nene, Tebello Nyokong
Summary: This study investigates the effects of ultrasonic frequency and power on the stability, reactive oxygen species yields, and cytotoxicity activities of different substituted ionic phthalocyanines (Pcs) in sonodynamic therapy (SDT). The degradation of Pcs increases with increasing power at Par II. Two reactive oxygen species, singlet oxygen and hydroxyl radicals, were detected in ultrasound treated Pcs. Par I was chosen for SDT, photodynamic therapy (PDT), and photo-sonodynamic therapy (PSDT) due to minimal degradation of most Pcs. PSDT generally shows improved therapeutic efficacies compared to SDT and PDT mono treatments.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Nnamdi Nwahara, Garth Abrahams, John Mack, Earl Prinsloo, Tebello Nyokong
Summary: This study presents a liposome loaded-silicon (IV) phthalocyanine (SiPc) with naphthoquinone axial ligands as hypoxia-responsive prodrug-like moieties (Prodrug-SiPc). Computational methods were used to assess the photophysical, photochemical and electrochemical redox properties of Prodrug-SiPc, revealing the relationship between material structure and properties. The liposomal encapsulation of Prodrug-SiPc resulted in potential photodynamic therapy (PDT) drug candidates, which took advantage of the hypoxic microenvironment of tumors to enhance therapeutic efficacy compared to typical PDT.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Lindokuhle Cindy Nene, Tebello Nyokong
Summary: This study explores the effects of gold and silver nanoparticles on the in vitro anticancer photo and sono-dynamic therapy and their combination therapy using cationic thiazole-phthalocyanines. The results show that conjugation to nanoparticles increases the generation of oxygen species and the combination therapy exhibits higher anticancer activity compared to monotherapies.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Gugu Kubheka, Nthabeleng Molupe, John Mack, Tebello Nyokong
Summary: The ease of functionalization of BODIPY dyes allows for the preparation of pH indicators by introducing suitable functional groups. In this study, two dimethylamino substituted BODIPY dyes were synthesized and characterized, and their photophysical properties and pH response were investigated.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2023)
Article
Chemistry, Analytical
Gugu Kubheka, Estela Climent, Charlie Tobias, Knut Rurack, John Mack, Tebello Nyokong
Summary: This study used azaBODIPY dyes doped into polystyrene particles as optical probes for the detection of high-risk HPV types. The particles were successfully attached with HPV DNA single strands, and demonstrated low detection limits and a narrow detection range for HPV11. The results suggest that these particles have the potential for multiplex assays and further study.
Article
Chemistry, Applied
Chenming Chan, Jia Li, Jianwei Wu, Youchun Zi, Zhaoli Xue, Mahlatse Ledwaba, John Mack, Tebello Nyokong
Summary: Due to the significant hazardous impact of Hg2+ on the environment and ecosystem, there is a need for highly sensitive and selective Hg2+ probes. A new imidazole-based Hg2+ probe has been synthesized and characterized, which can detect Hg2+ through an ion-specific co-ordination mechanism. The probe exhibits significant fluorescence enhancement in acetonitrile solutions containing Hg2+, with a limit of detection of 0.30 mu M. Additionally, it shows utility in detecting Hg2+ in biochemical systems and the environment based on paper test strip and HeLa cell experiments.
Article
Chemistry, Analytical
Lunathi Ncwane, Lekhetho S. Mpeta, Tebello Nyokong
Summary: This study investigates the effect of detonation nanodiamonds (DNDs) on the electrocatalytic properties of an asymmetrically substituted cobalt phthalocyanine (CoPc). The addition of DNDs enhances the electrochemical behavior of CoPc. Various modifications of glassy carbon electrode (GCE) were made using CoPc alone, CoPc-DNDs(pi pi) or CoPc@DNDs, and the sequential addition of CoPc and DNDs. Among these modifications, GCE/CoPc@DNDs showed the best electrocatalytic activity for the detection of hydrazine, with a catalytic rate of 9.3x10(4) M-1.s(-1) and a detection limit of 0.33 mu M.
Article
Polymer Science
James Oyim, Edith Amuhaya, Tebello Nyokong
Summary: Photocatalyst adsorbents based on porphyrin-immobilized activated carbon-decorated polyacrylonitrile (InP(PAN/AC)) were studied for the removal of methylene blue dye and Ciprofloxacin in water. The InP(PAN/AC) demonstrated high removal efficiency and structural integrity after multiple cycles of usage. The study highlights the coordinated contribution of singlet oxygen and hydroxyl radical in the photodegradation process and emphasizes the importance of an integrated system with adsorption and photodegradation capabilities for water treatment.
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2023)
Article
Chemistry, Physical
Sithi Mgidlana, Yolande Ikala Openda, Tebello Nyokong
Summary: Zinc phthalocyanine complexes are covalently linked to metallic nanoparticles through amide and ester bonds. The photocatalytic activity of these conjugates is evaluated for the degradation of methylene blue, tetracycline, and diben-zothiophene. The results show that the prepared phthalocyanine complexes exhibit enhanced photocatalytic efficiency in the presence of nanoparticles. Furthermore, the conjugates also demonstrate promising photodynamic antimicrobial chemotherapy activity against Staphylococcus aureus bacteria, with Ag2WO4-based nanoconjugates showing the highest antimicrobial activity compared to other materials.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Oncology
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: Antimicrobial photodynamic inactivation (aPDI) is an effective method for eradicating drug-resistant microorganisms due to its minimal possibility of microbial resistance. This study focuses on the preparation and characterization of novel neutral and cationic morpholine containing Schiff base phthalocyanines. The cationic complexes show promising photodynamic activity against various microorganisms, while the neutral complexes are not suitable for antimicrobial studies. The effectiveness of aPDI is dependent on the concentration and light dose.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Inorganic & Nuclear
Reitumetse Nkhahle, Nthabeleng Molupe, John Mack, Tebello Nyokong
Summary: This work provides a synthesis method for an unsymmetrically substituted cobalt phthalocyanine and its symmetric counterpart, and applies them in electrocatalysis. The results show that the unsymmetrically substituted cobalt phthalocyanine exhibits superior performance in electrocatalytic reactions. The reactivity of the complexes is further evaluated using theoretical calculations, which indicate that the unsymmetrically substituted compound has higher reactivity.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Sixolile Centane, Sithi Mgidlana, Yolande Openda, Nobuhle Ndebele, Tebello Nyokong
Summary: Surface functionalization plays a crucial role in improving efficiency and selectivity of biosensors. This study explores the use of asymmetric and symmetric cobalt phthalocyanines as biorecognition element immobilization and signal amplification for the electrochemical detection of HER2. The cobalt phthalocyanines were coupled with sulphur nitrogen graphene quantum dots for enhanced performance. The aptasensors demonstrated great potential in monitoring HER2 levels for breast cancer management.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
