Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition

Role of Phosphorylation in Moesin Interactions with PIP 2 -Containing Biomimetic Membranes

(2018) Quentin Lubart et al.   BIOPHYSICAL JOURNAL

UniProt: the universal protein knowledgebase

(2018) The UniProt Consortium   NUCLEIC ACIDS RESEARCH

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

(2018) Krishna Chinthalapudi et al.   Nature Communications

Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation

(2018) Eun-Ju Jin et al.   Scientific Reports

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

(2018) Feng-Ching Tsai et al.   eLife

Role of Ezrin Phosphorylation in HIV-1 Replication

(2018) Haruka Kamiyama et al.   Frontiers in Microbiology

Regulation of actin-based apical structures on epithelial cells

(2018) Thaher Pelaseyed et al.   JOURNAL OF CELL SCIENCE

How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?

(2017) Kathryn Wolhuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins

(2017) Jianchao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides

(2017) Yosuke Senju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvements to the APBS biomolecular solvation software suite

(2017) Elizabeth Jurrus et al.   PROTEIN SCIENCE

Myosin 7 and its adaptors link cadherins to actin

(2017) I-Mei Yu et al.   Nature Communications

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

(2017) Kana T. Furukawa et al.   Cell Reports

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

(2017) Ho Yee Joyce Fung et al.   eLife

Quantitative global proteome and lysine succinylome analyses provide insights into metabolic regulation and lymph node metastasis in gastric cancer

(2017) Yongxi Song et al.   Scientific Reports

Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin

(2016) J. M. Phang et al.   BIOCHEMICAL JOURNAL

Mode of Ezrin-Membrane Interaction as a Function of PIP 2 Binding and Pseudophosphorylation

(2016) Victoria Shabardina et al.   BIOPHYSICAL JOURNAL

Pathogenese und Molekularpathologie des Vestibularisschwannoms

(2016) M. Brodhun et al.   HNO

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin ( MSN ) gene

(2016) Chantal Lagresle-Peyrou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Atlantic salmon genome provides insights into rediploidization

(2016) Sigbjørn Lien et al.   NATURE

Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer

(2016) Adam K. Morrow et al.   Oncotarget

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

Structure, Regulation, and Functional Diversity of Microvilli on the Apical Domain of Epithelial Cells

(2015) Cécile Sauvanet et al.   Annual Review of Cell and Developmental Biology

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

(2015) Youjun Li et al.   CELL RESEARCH

MT1-MMP recognition by ERM proteins and its implication in CD44 shedding

(2015) Shin-ichi Terawaki et al.   GENES TO CELLS

Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin

(2015) Zhiyi Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The SH3 regulatory domain of the hematopoietic cell kinase Hck binds ELMO via its polyproline motif

(2015) Rida Awad et al.   FEBS Open Bio

Multistep Phosphorylation by Oncogenic Kinases Enhances the Degradation of the NF2 Tumor Suppressor Merlin

(2015) Minja Laulajainen et al.   NEOPLASIA

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

(2014) Wei Li et al.   CANCER CELL

Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition

(2014) Jie Jia et al.   CELL

Ezrin expression and cell survival regulation in colorectal cancer

(2014) Premila D. Leiphrakpam et al.   CELLULAR SIGNALLING

Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function

(2014) Tomoyuki Mori et al.   GENES TO CELLS

Structural Basis of the Binding of Merlin FERM Domain to the E3 Ubiquitin Ligase Substrate Adaptor DCAF1

(2014) Youjun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERM proteins at a glance

(2014) Andrea I. McClatchey   JOURNAL OF CELL SCIENCE

Rho-ROCK-Dependent Ezrin-Radixin-Moesin Phosphorylation Regulates Fas-Mediated Apoptosis in Jurkat Cells

(2014) M. Hebert et al.   JOURNAL OF IMMUNOLOGY

Molecular Conformation of the Full-Length Tumor Suppressor NF2/Merlin—A Small-Angle Neutron Scattering Study

(2014) Jahan Ali Khajeh et al.   JOURNAL OF MOLECULAR BIOLOGY

Ezrin Is a Component of the HIV-1 Virological Presynapse and Contributes to the Inhibition of Cell-Cell Fusion

(2014) N. H. Roy et al.   JOURNAL OF VIROLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway

(2014) Qi-Hong Jiang et al.   TheScientificWorldJOURNAL

High expression of ezrin predicts poor prognosis in uterine cervical cancer

(2013) Jienan Kong et al.   BMC CANCER

Molecular pathogenesis of malignant mesothelioma

(2013) Y. Sekido   CARCINOGENESIS

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection

(2013) Terence N. Bukong et al.   HEPATOLOGY

The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex

(2013) Sara Solinet et al.   JOURNAL OF CELL BIOLOGY

Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors

(2013) Devin K. Schweppe et al.   Journal of Proteomics

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Merlin sumoylation is required for its tumor suppressor activity

(2013) Q Qi et al.   ONCOGENE

Divergent Protein Motifs Direct Elongation Factor P-Mediated Translational Regulation in Salmonella enterica and Escherichia coli

(2013) S. J. Hersch et al.   mBio

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

A Propensity Scale for Type II Polyproline Helices (PPII): Aromatic Amino Acids in Proline-Rich Sequences Strongly Disfavor PPII Due to Proline–Aromatic Interactions

(2012) Alaina M. Brown et al.   BIOCHEMISTRY

Binding of moesin and ezrin to membranes containing phosphatidylinositol (4,5) bisphosphate: A comparative study of the affinity constants and conformational changes

(2012) Ofelia Maniti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Model membranes to shed light on the biochemical and physical properties of ezrin/radixin/moesin

(2012) Ofélia Maniti et al.   BIOCHIMIE

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus

(2012) Wei Li et al.   EMBO REPORTS

Open Conformation of Ezrin Bound to Phosphatidylinositol 4,5-Bisphosphate and to F-actin Revealed by Neutron Scattering

(2012) Jayant James Jayasundar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Moesin, a Protein That Links Actin Cytoskeleton to the Plasma Membrane, Occurs by Phosphatidylinositol 4,5-bisphosphate (PIP2) Binding Sequentially to Two Sites and Releasing an Autoinhibitory Linker

(2012) Khadija Ben-Aissa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease

(2012) Puneet Anand et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ezrin Ubiquitylation by the E3 Ubiquitin Ligase, WWP1, and Consequent Regulation of Hepatocyte Growth Factor Receptor Activity

(2012) Rania F. Zaarour et al.   PLoS One

Ezrin Interacts with the SARS Coronavirus Spike Protein and Restrains Infection at the Entry Stage

(2012) Jean Kaoru Millet et al.   PLoS One

Activation of F-Actin Binding Capacity of Ezrin: Synergism of PIP2 Interaction and Phosphorylation

(2011) Sabine Bosk et al.   BIOPHYSICAL JOURNAL

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice

(2011) Y. Liu et al.   BLOOD

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement

(2011) Djanybek M. Adyshev et al.   CELLULAR SIGNALLING

Ezrin, Radixin and Moesin: key regulators of membrane–cortex interactions and signaling

(2011) Amanda L Neisch et al.   CURRENT OPINION IN CELL BIOLOGY

Expression of Ezrin in Human Embryonic, Fetal, and Normal Adult Tissues

(2011) Jian-Jun Xie et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

(2011) T. Mani et al.   MOLECULAR AND CELLULAR BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor

(2011) S. D. Yogesha et al.   PROTEIN SCIENCE

Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo

(2011) L. Wu et al.   SCIENCE

Phosphatidylinositol 4,5-Bisphosphate-Induced Conformational Change of Ezrin and Formation of Ezrin Oligomers

(2010) Kevin Carvalho et al.   BIOCHEMISTRY

Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade

(2010) Mian He et al.   BMC CANCER

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Ezrin promotes invasion and metastasis of pancreatic cancer cells

(2010) Yunxiao Meng et al.   Journal of Translational Medicine

Ubiquitylation of an ERAD Substrate Occurs on Multiple Types of Amino Acids

(2010) Yuichiro Shimizu et al.   MOLECULAR CELL

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma

(2010) F. C. Morales et al.   NEURO-ONCOLOGY

Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants

(2010) L. B. Bensenor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

ERM protein moesin is phosphorylated by advanced glycation end products and modulates endothelial permeability

(2009) Xiaohua Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma

(2009) Chun-Nan Yeh et al.   BMC CANCER

Akt Phosphorylation of Merlin Enhances Its Binding to Phosphatidylinositols and Inhibits the Tumor-Suppressive Activities of Merlin

(2009) M. Okada et al.   CANCER RESEARCH

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane

(2009) Jian-Jiang Hao et al.   JOURNAL OF CELL BIOLOGY

Ezrin-Radixin-Moesin Family Proteins Are Involved in Parvovirus Replication and Spreading

(2009) J. P. F. Nuesch et al.   JOURNAL OF VIROLOGY

Neurofibromatosis type 2 (NF2): A clinical and molecular review

(2009) D Gareth R Evans   Orphanet Journal of Rare Diseases

Genetic and Proteomic Evidence for Roles of Drosophila SUMO in Cell Cycle Control, Ras Signaling, and Early Pattern Formation

(2009) Minghua Nie et al.   PLoS One

A FERM domain autoregulates Drosophila myosin 7a activity

(2009) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex

(2009) Andrea I. McClatchey et al.   TRENDS IN CELL BIOLOGY

Actin Binding of Ezrin Is Activated by Specific Recognition of PIP2-Functionalized Lipid Bilayers†

(2008) Matthias Janke et al.   BIOCHEMISTRY

MicroRNA-183 regulates Ezrin expression in lung cancer cells

(2008) Guofu Wang et al.   FEBS LETTERS

Structural Basis for CD44 Recognition by ERM Proteins

(2008) Tomoyuki Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Cytoplasmic Tail of Adhesion Molecule CD43 and Its Binding to ERM Proteins

(2008) Yumiko Takai et al.   JOURNAL OF MOLECULAR BIOLOGY

Properties of an Ezrin Mutant Defective in F-actin Binding

(2008) Henri S. Saleh et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantitative Analysis of the Binding of Ezrin to Large Unilamellar Vesicles Containing Phosphatidylinositol 4,5 Bisphosphate

(2007) Guillaume Blin et al.   BIOPHYSICAL JOURNAL