Article
Cell Biology
Jorian J. Sepers, Joao J. Ramalho, Jason R. Kroll, Ruben Schmidt, Mike Boxem
Summary: The interaction between ERM-1 and NRFL-1 plays a role in intestinal lumen formation in C. elegans. The localization of NRFL-1 depends on its interaction with ERM-1. Loss of NRFL-1 does not affect the localization or activity of ERM-1, but specific mutations in ERM-1 that interact with NRFL-1 have severe effects on intestinal lumen formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Kevin Leguay, Barbara Decelle, Yu Yan He, Anthony Pagniez, Mireille Hogue, Hiroyuki Kobayashi, Christian Le Gouill, Michel Bouvier, Sebastien Carreno
Summary: ERM proteins, including ezrin, radixin, and moesin, play a crucial role in cell signaling and morphogenesis. Understanding the regulation of these proteins is vital for studying cell shape control mechanisms and developing innovative cancer therapies.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Takuro Kobori, Yui Ito, Yuka Sawada, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: CD47 is overexpressed on the surface of pancreatic cancer cells and is correlated with worse clinical outcomes. In KP-2 cells, ezrin/radixin family members contribute to the cellular membrane localization of CD47. Specifically, radixin interacts with CD47 and regulates its surface expression in KP-2 cells.
Article
Biochemistry & Molecular Biology
Chihiro Tanaka, Takuro Kobori, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: The ERM family scaffold proteins play a role in PD-L1 expression in HeLa cells, with ezrin potentially acting as a scaffold protein for PD-L1 and regulating its protein expression. This finding suggests ezrin could be a therapeutic target for cervical cancer, improving immune checkpoint blockade therapy.
Article
Medicine, General & Internal
Rina Doukuni, Takuro Kobori, Chihiro Tanaka, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: Moesin may be a scaffold protein responsible for the plasma membrane expression of PD-L1 in human uterine cervical SCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Mayuka Tameishi, Takuro Kobori, Chihiro Tanaka, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: The study suggests that ezrin may contribute to the cell surface localization of PD-L1 as a scaffold protein in JEG-3 cells, potentially offering a therapeutic target to improve current ICB therapy in patients with GTN.
Article
Chemistry, Physical
Jinyuan Liu, Lin Kang, Ishara Ratnayake, Phil Ahrenkiel, Steve Smith, Congzhou Wang
Summary: Targeting CD146 with low-dose gold nanorods and mild hyperthermia can effectively stop cancer cell migration by disrupting the actin cytoskeleton. This approach alters cell morphology and inhibits cell migration by depleting membrane CD146 and interfering with ezrin-radixin-moesin phosphorylation. The findings suggest a versatile and safe strategy for preventing cancer metastasis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Medicinal
Takuro Kobori, Chihiro Tanaka, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: The interaction of PD-L1 with ERM proteins in colorectal adenocarcinoma cells can affect its expression on the cell membrane, thereby potentially modulating the efficacy of PD-1/PD-L1 blockade therapies.
Article
Immunology
Takuro Kobori, Yui Ito, Rina Doukuni, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: Despite the successful use of immune checkpoint blockers in treating various cancer types, current therapies are only effective for a subset of cervical cancer patients. CD47, which is commonly overexpressed in cancer cells, has been shown to interact with macrophage receptors and act as a dominant macrophage checkpoint. Radixin, an intracellular scaffold protein, has been found to modulate the plasma membrane localization and functionality of CD47 in HeLa cells. This suggests that radixin could be a potential target for improving immunotherapies by regulating CD47 localization.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Immunology
Byeong-Oh Hwang, Se-Young Park, Eunae Sandra Cho, Xianglan Zhang, Sun Kyoung Lee, Hyung-Joon Ahn, Kyung-Soo Chun, Won-Yoon Chung, Na-Young Song
Summary: Cancer tissues form complex and heterogeneous tumor microenvironments, where platelets play a crucial role in promoting cancer progression. In oral squamous cell carcinoma, high platelet counts and low tumor-stromal ratio are associated with increased metastasis and poor prognosis, suggesting that targeting the interaction between platelets and cancer cells could be a promising therapeutic strategy to inhibit cancer invasion and metastasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Chihiro Tanaka, Takuro Kobori, Rie Okada, Rina Doukuni, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Nobumasa Takagaki, Tokio Obata
Summary: This study reveals the mechanism of PD-L1 localization on endometrial cancer cell surfaces. The ERM protein family, with Ezrin as a key scaffold protein, contributes to the cell surface localization of PD-L1.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Mayuka Tameishi, Honami Ishikawa, Chihiro Tanaka, Takuro Kobori, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: Programmed death ligand-1 (PD-L1) is a molecule on the plasma membrane of cancer cells that negatively regulates immune surveillance. This study suggests that ezrin may be responsible for the plasma membrane expression of PD-L1 in ovarian cancer cells, making it a potential therapeutic target for improving immune checkpoint inhibitor treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Anshuman Das, Efrain E. Rivera-Serrano, Xin Yin, Christopher M. Walker, Zongdi Feng, Stanley M. Lemon
Summary: In this Review, the authors discuss quasi-enveloped virions, their entry and release from human host cells, and their impact on host immunity and pathogenesis. They focus on hepatitis A and E viruses, which were previously considered non-enveloped but are now known to be released as quasi-enveloped virions cloaked in host membranes. Despite lacking virally encoded proteins on their surface, these virions efficiently enter cells and replicate. The authors also describe the mechanisms by which specific peptide sequences in the capsids of these virions mediate their release from hepatocytes and the current understanding of their cell entry mechanism.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olga Simo-Servat, Hugo Ramos, Patricia Bogdanov, Marta Garcia-Ramirez, Jordi Huerta, Cristina Hernandez, Rafael Simo
Summary: This study found that the overexpression of ERM proteins in diabetic mice may be one of the mechanisms leading to vascular leakage in diabetic retinopathy. Moreover, the upregulation of the ERM complex by diabetes is induced by inflammatory mediators rather than high glucose itself.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yosuke Senju, Emi Hibino
Summary: Neurofibromatosis type 2 (NF2), caused by the mutated merlin gene, belongs to the FERM domain-containing 4.1 superfamily. Merlin, a tumor suppressor, shares sequence homology with ERM proteins and plays important roles in cell-cell adhesions. This article provides insights into the molecular functions of merlin and its interactions with PI(4,5)P2, shedding light on its fundamental roles in cells and tissues.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)