Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives

Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature

(2019) Ivana Milosevic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

(2019) Hideaki Morita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

(2018) Yuefeng Huang et al.   SCIENCE

Pulmonary neuroendocrine cells amplify allergic asthma responses

(2018) Pengfei Sui et al.   SCIENCE

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand interaction

(2017) Diamanda Rigas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PD-1 regulates KLRG1+group 2 innate lymphoid cells

(2017) Samuel Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Androgen signaling negatively controls group 2 innate lymphoid cells

(2017) Sophie Laffont et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmune hepatitis: From current knowledge and clinical practice to future research agenda

(2017) Marcial Sebode et al.   LIVER INTERNATIONAL

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

(2017) Simon Rauber et al.   NATURE MEDICINE

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

(2017) Hayato Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

(2017) Benjamin Krämer et al.   PLoS Pathogens

The Role of Innate Lymphoid Cells in Immune-Mediated Liver Diseases

(2017) Meifang Liu et al.   Frontiers in Immunology

Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score

(2017) Hannah C. Jeffery et al.   PLoS One

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells

(2016) Andrea Kristina Horst et al.   Cellular & Molecular Immunology

Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation

(2016) Itziar Martinez-Gonzalez et al.   IMMUNITY

Immunity, tolerance and autoimmunity in the liver: A comprehensive review

(2016) Derek G. Doherty   JOURNAL OF AUTOIMMUNITY

A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis

(2016) Katrin Neumann et al.   JOURNAL OF IMMUNOLOGY

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis

(2016) Kevin M. Vannella et al.   Science Translational Medicine

Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells

(2015) B. Ruiter et al.   CLINICAL AND EXPERIMENTAL ALLERGY

ICOS regulates the pool of group 2 innate lymphoid cells under homeostatic and inflammatory conditions in mice

(2015) Daniela Paclik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

(2015) Hideaki Morita et al.   IMMUNITY

ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity

(2015) Hadi Maazi et al.   IMMUNITY

Amphiregulin promotes the immunosuppressive activity of intrahepatic CD4+regulatory T cells to impair CD8+T-cell immunity against hepatitis B virus infection

(2015) Kai Dai et al.   IMMUNOLOGY

Type 1 innate lymphoid cells contribute to the pathogenesis of chronic hepatitis B

(2015) Zhiqing Yang et al.   Innate Immunity

Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

(2015) Patricia Aparicio-Domingo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmune hepatitis – Update 2015

(2015) Michael P. Manns et al.   JOURNAL OF HEPATOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

(2015) Laurel A. Monticelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

(2015) G. Gasteiger et al.   SCIENCE

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

(2015) Chad McKee et al.   Scientific Reports

IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells

(2015) Anne-Gaelle Besnard et al.   PLoS Pathogens

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

(2014) Ryoji Yagi et al.   IMMUNITY

Biliary repair and carcinogenesis are mediated by IL-33–dependent cholangiocyte proliferation

(2014) Jun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Gata3drives development of RORγt+group 3 innate lymphoid cells

(2014) Nicolas Serafini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrahepatic Innate Lymphoid Cells Secrete IL-17A and IL-17F That Are Crucial for T Cell Priming in Viral Infection

(2014) Z. Jie et al.   JOURNAL OF IMMUNOLOGY

Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses

(2014) A. S. Mirchandani et al.   JOURNAL OF IMMUNOLOGY

Activation of Type 3 Innate Lymphoid Cells and Interleukin 22 Secretion in the Lungs During Streptococcus pneumoniae Infection

(2014) Laurye Van Maele et al.   JOURNAL OF INFECTIOUS DISEASES

Hepatocytes induce Foxp3+ regulatory T cells by Notch signaling

(2014) Sven Burghardt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells

(2014) Yuefeng Huang et al.   NATURE IMMUNOLOGY

Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis

(2014) H. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

(2014) S. P. Spencer et al.   SCIENCE

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation

(2013) Qi Yang et al.   IMMUNITY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

(2013) Jan-Eric Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 Induces Nuocytes and Modulates Liver Injury in Viral Hepatitis

(2013) Y. Liang et al.   JOURNAL OF IMMUNOLOGY

Essential Functions for ID Proteins at Multiple Checkpoints in Invariant NKT Cell Development

(2013) M. Verykokakis et al.   JOURNAL OF IMMUNOLOGY

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

(2013) Atsuhiro Matsumoto et al.   PLoS One

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

(2012) Jenny Mjösberg et al.   IMMUNITY

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

(2012) Ana Camelo et al.   JOURNAL OF GASTROENTEROLOGY

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Transcription factor RORα is critical for nuocyte development

(2012) See Heng Wong et al.   NATURE IMMUNOLOGY

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms

(2012) Toshiro Takai   ALLERGOLOGY INTERNATIONAL

The multiple roles of amphiregulin in human cancer

(2011) Benoit Busser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cross-presentation of antigen by diverse subsets of murine liver cells

(2011) Mohammad R. Ebrahimkhani et al.   HEPATOLOGY

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Protective role of IL-33/ST2 axis in Con A-induced hepatitis

(2011) Vladislav Volarevic et al.   JOURNAL OF HEPATOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

(2010) Steven A. Saenz et al.   TRENDS IN IMMUNOLOGY

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

Suppression of Con A-induced hepatitis induction in ICOS-deficient mice

(2009) Shiho Watanabe et al.   IMMUNOLOGY LETTERS

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis

(2008) Maria J. Perugorria et al.   HEPATOLOGY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA