Article
Immunology
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadova, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Summary: T-bet deficient mice show an increase in ILC3 cellularity but do not have a greater risk of developing spontaneous colitis. T-bet appears to control the number of ILC3 cells, but does not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Laura Kiekens, Sigrid Wahlen, Eva Persyn, Zenzi De Vos, Tom Taghon, Bart Vandekerckhove, Georges Leclercq
Summary: The study demonstrates that human ILC3s can convert into functional NK cells, with T-BET being the main driver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jan-Hendrik Schroeder, Luke B. Roberts, Katrin Meissl, Jonathan W. Lo, Dominika Hromadova, Kelly Hayes, Tomasz Zabinski, Emily Read, Catarina Moreira Heliodoro, Rita Reis, Jane K. Howard, Richard K. Grencis, Joana F. Neves, Birgit Strobl, Graham M. Lord
Summary: ILC1 play a significant role in intestinal immune response, with T-bet being a key factor for their maintenance. Targeting T-bet or its downstream transcriptional targets may reduce ILC1 and have therapeutic effects on inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Drishti Tiwari, Nancy Ahuja, Sumit Kumar, Rashi Kalra, Ravikanth Nanduri, Shalini Gupta, Asheesh Kumar Khare, Ella Bhagyaraj, Rashmi Arora, Pawan Gupta
Summary: Nr1d1 is found to play a crucial role in T helper cell polarization and inhibits the formation of Th2 cells by suppressing the transcription of GATA3 gene. Nr1d1 forms a repression complex with its companion protein on the promoter of GATA3 gene. Additionally, Nr1d1 interacts with other gene subsets to regulate metabolism, immunity, and brain functions, providing evidence for the genetic connection between asthma and other comorbid conditions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Jiman Kang, Jedson R. Liggett, Digvijay Patil, Suman Ranjit, Katrina Loh, Anju Duttargi, Yuki Cui, Kesha Oza, Brett S. Frank, DongHyang Kwon, Bhaskar Kallakury, Simon C. Robson, Thomas M. Fishbein, Wanxing Cui, Khalid Khan, Alexander Kroemer
Summary: ILC1 cells play a significant role in fatty liver and ischemia-reperfusion injury under conditions of high-fat diet.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mingzhu Zheng, Kairui Mao, Difeng Fang, Dan Li, Jun Lyu, Dingkang Peng, Xi Chen, Nikki Cannon, Gangqing Hu, Jiajia Han, Keji Zhao, Wanjun Chen, Jinfang Zhu
Summary: IgA production in the gut relies on IgA-producing plasma cells derived from conventional B cells, with T cells and helper-like ILCs playing crucial roles in the formation of lymphoid structures in the gut. However, the functions of non-LTi helper-like ILCs in promoting IgA production are still not well understood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Haruei Ogino, Keita Fukaura, Yoichiro Iboshi, Yousuke Nagamatsu, Hiroaki Okuno, Kei Nishioka, Yuichiro Nishihara, Yoshimasa Tanaka, Takatoshi Chinen, Eikich Ihara, Yoshihiro Ogawa
Summary: The study found that in patients with ulcerative colitis, there are clusters of immune responses related to Th17 and Th1/Th2, with IL-23 expression potentially associated with disease severity. IL-23 may play a key role in the pathogenesis of ulcerative colitis and be an important factor in evaluating the disease condition of patients.
Article
Multidisciplinary Sciences
Katja J. Jarick, Patrycja M. Topczewska, Manuel O. Jakob, Hiroshi Yano, Mohammad Arifuzzaman, Xuemei Gao, Sotiria Boulekou, Vladislava Stokic-Trtica, Pierre S. Leclere, Alexandra Preusser, Zoe A. Rompe, Anton Stamm, Amy M. Tsou, Coco Chu, Frederik R. Heinrich, Gabriela M. Guerra, Pawel Durek, Andranik Ivanov, Dieter Beule, Sofia Helfrich, Claudia U. Duerr, Anja A. Kuehl, Christina Stehle, Chiara Romagnani, Mir-Farzin Mashreghi, Andreas Diefenbach, David Artis, Christoph S. N. Klose
Summary: This article investigates the role of innate lymphoid cells (ILCs) in protective immunity. Using a mouse model specific to ILCs, researchers found that ILC2s have non-redundant functions during steady state and disease, and they interact with adaptive immune cells to organize the immune system.
Article
Multidisciplinary Sciences
Murshed H. Sarkar, Ryoji Yagi, Yukihiro Endo, Ryo Koyama-Nasu, Yangsong Wang, Ichita Hasegawa, Toshihiro Ito, Ilkka S. Junttila, Jinfang Zhu, Motoko Y. Kimura, Toshinori Nakayama
Summary: IFN gamma suppresses Th2 cell proliferation by decreasing the expression of GFI1, a key molecule in this process. Deletion of Gfi1 gene in Th2 cells leads to impaired proliferation, while enforced expression of GFI1 restores defective proliferation even in the presence of IFN gamma.
Review
Cell Biology
Sonja I. Buschow, Diahann T. S. L. Jansen
Summary: Research on the impaired T cell responses in chronic hepatitis B patients has mainly focused on CD8(+) T cells, while CD4(+) T cells are crucial in the development of long-lasting effector CD8(+) T cells. This review discusses the importance of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.
Article
Immunology
Si Xie, Liu Yang, Xiaoyue Bi, Wen Deng, Tingting Jiang, Yanjie Lin, Shiyu Wang, Lu Zhang, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Ge Shen, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Yao Lu, Rui Song, Yao Xie, Minghui Li
Summary: The activation of CD8+ T lymphocytes is associated with the occurrence of acute and chronic hepatitis B. CD8+ T lymphocytes play an important role in the development of hepatitis B, and their activation status is correlated with the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Urology & Nephrology
Ruifeng Wang, Yiping Wang, David C. H. Harris, Qi Cao
Summary: Innate immune cells, including a newly discovered group of innate lymphoid cells (ILCs), play critical roles in kidney diseases by providing immunomodulatory cytokines and guiding immune responses. Understanding the function of ILCs in normal and diseased kidneys emphasizes the emerging importance of ILC-regulated immunity for future research and therapeutic interventions.
KIDNEY INTERNATIONAL
(2021)
Review
Immunology
Amy T. Hsu, Timothy A. Gottschalk, Evelyn Tsantikos, Margaret L. Hibbs
Summary: The lung is a vital mucosal organ constantly exposed to the external environment, with an evolved immune system that responds to danger signals and maintains tolerance to harmless aeroantigens. Innate lymphoid cells (ILCs) in the lung play important roles in early responses to pathogens and the development of adaptive immunity, but may also contribute to chronic lung diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Feng Li, Zhou Liang, Haojie Zhong, Xinrong Hu, Ziwen Tang, Changjian Zhu, Jiani Shen, Xu Han, Ruoni Lin, Ruilin Zheng, Ruihan Tang, Huajing Peng, Xunhua Zheng, Chengqiang Mo, Peisong Chen, Xin Wang, Qiong Wen, Jianbo Li, Xi Xia, Hongjian Ye, Yagui Qiu, Jianwen Yu, Dongying Fu, Jiaqi Liu, Rong Wang, Huixin Xie, Yun Guo, Xiaoyan Li, Jinjin Fan, Qinghua Liu, Haiping Mao, Wei Chen, Yi Zhou
Summary: In lupus nephritis (LN), gut-derived group 3 innate lymphoid cells (ILC3s) migrate from the small intestine to the kidney via the CXCR6/CXCL16 axis, contributing to the progression of LN, including spleen and lymph node enlargement, antibody production, and renal injury. In renal ectopic lymphoid structures (ELS), ILC3s induce B cell activation in a Delta-like1 (DLL1)/Notch-dependent manner, accompanied by up-regulation of Deltex1 and MAML1.
Article
Immunology
Yime Zhang, Luni Hu, Guanqun Ren, Yanyu Zeng, Xingyu Zhao, Chao Zhong
Summary: This study compared the transcriptomes of innate lymphoid cells (ILCs) and CD4+ T helper (Th) cells using bulk RNA-sequencing data and identified gene sets that distinguish ILCs from Th cells and different immune responses. Chromatin accessibility analysis revealed that ILCs rely more on specific transcriptional regulation at promoter regions compared to Th cells. Additionally, ILCs and Th cells are under differential transcriptional regulation, with ILCs being regulated by multiple transcription factors such as ROR alpha, GATA3, and NF-kappa B, while Th cells are regulated by AP-1. These findings highlight the substantial distinctions in regulatory machineries between ILCs and Th cells, providing a comprehensive understanding of their unique roles during immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Zhiqiang Tian, Yao Liu, Bo Yang, Ji Zhang, Haiyang He, Hui Ge, Yuzhang Wu, Zigang Shen
Article
Immunology
Zhou Zhou, Zhiqiang Tian, Mengjie Zhang, Yuxun Zhang, Bing Ni, Fei Hao
IMMUNOLOGICAL INVESTIGATIONS
(2018)
Article
Gastroenterology & Hepatology
Hong-Xia Guo, Nan Ye, Ping Yan, Min-Yue Qiu, Ji Zhang, Zi-Gang Shen, Hai-Yang He, Zhi-Qiang Tian, Hong-Li Li, Jin-Tao Li
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Jieping Li, Li Yang, Rui Shen, Li Gong, Zhiqiang Tian, Huarong Qiu, Zhe Shi, Lichen Gao, Hongwu Sun, Guangsen Zhang
JOURNAL OF NANOBIOTECHNOLOGY
(2018)
Article
Oncology
Bo Lei, Jian Zhou, Xiuyun Xuan, Zhigiang Tian, Mengjie Zhang, Weiwu Gao, Yuxin Lin, Bing Ni, Hui Pang, Weiping Fan
Article
Gastroenterology & Hepatology
Weiwu Gao, Zhengcai Jia, Yi Tian, Penghui Yang, Hui Sun, Chenhui Wang, Yi Ding, Mengjie Zhang, Yi Zhang, Di Yang, Zhiqiang Tian, Jian Zhou, Zhihua Ruan, Yuzhang Wu, Bing Ni
Article
Medicine, General & Internal
Liwen Luo, Li Jiang, Zhiqiang Tian, Xinqi Zhang
Correction
Immunology
Jintao Li, Ji Zhang, Hongxia Guo, Shimin Yang, Weiping Fan, Nan Ye, Zhiqiang Tian, Tiantian Yu, Guoping Ai, Zigang Shen, Haiyang He, Ping Yan, Hui Lin, Xue Luo, Hongli Li, Yuzhang Wu
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Liwen Luo, Junfeng Zhang, Jiali Yang, Hongyu Zhang, Yichen Tang, Di Yang, Hui Dong, Yuzhang Wu, Huaizhi Wang, Bing Ni, Zhiqiang Tian
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Cell & Tissue Engineering
Liwen Luo, Xiuying Jian, Hui Sun, Jinghao Qin, Yanqiu Wang, Ji Zhang, Zigang Shen, Di Yang, Changqing Li, Ping Zhao, MingHan Liu, Zhiqiang Tian, Yue Zhou
Summary: The study revealed the therapeutic effects of exosomes on intervertebral disc degeneration (IVDD), showing that they inhibit nucleus pulposus cell (NPC) apoptosis and activate the AKT and autophagy pathways to delay the progression of IVDD.
Article
Multidisciplinary Sciences
Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu
Summary: This study identified a novel enhancer, RORCE2, for the transcription factor RORγt, which interacts with Sox5 to modulate RORγt expression at the promoter level, providing insights into the regulation of Th17 differentiation and functions.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Liwen Luo, Junfeng Gong, Hongyu Zhang, Jinghao Qin, Changqing Li, Junfeng Zhang, Yu Tang, Yang Zhang, Jian Chen, Yue Zhou, Zhiqiang Tian, Yao Liu, MingHan Liu
Summary: The study demonstrated that stem cells derived from cartilage endplate cells could transdifferentiate into nucleus pulposus cells via autocrine exosomes, activating the HIF-1 alpha/Wnt pathway to promote invasion, migration, and differentiation, thus inhibiting intervertebral disc degeneration. Additionally, GATA4 played a key role in promoting TGF-beta secretion and enhancing the transdifferentiation of stem cells, ultimately aiding in intervertebral disc repair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Liwen Luo, Junfeng Gong, Zhouguang Wang, Yao Liu, Jiaming Cao, Jinghao Qin, Rui Zuo, Hongyu Zhang, Shuai Wang, Ping Zhao, Di Yang, Mengjie Zhang, Yanqiu Wang, Junfeng Zhang, Yue Zhou, Changqing Li, Bing Ni, Zhiqiang Tian, MingHan Liu
Summary: This study presents a novel and efficient non-invasive combinational strategy for treating IVDD by injecting ECM-Gels loaded with CESCs that express sustained release of functional exosomes.
BIOACTIVE MATERIALS
(2022)
Review
Medicine, General & Internal
Bo Lei, Zhiqiang Tian, Weiping Fan, Bing Ni
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Zhiqiang Tian, Ji Zhang, Haiyang He, Jintao Li, Yuzhang Wu, Zigang Shen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.