Article
Pharmacology & Pharmacy
Huaqiang Tao, Wenming Li, Wei Zhang, Chen Yang, Chun Zhang, Xiaolong Liang, Juan Yin, Jiaxiang Bai, Gaoran Ge, Haifeng Zhang, Xing Yang, Hongxia Li, Yaozeng Xu, Yuefeng Hao, Yu Liu, Dechun Geng
Summary: UA administration reduced systemic bone loss in ovariectomized animals by suppressing osteoclast formation through modulation of the inflammatory signal-dependent pyroptosis pathway, indicating its potential as a safe and promising therapeutic strategy for osteoclast-related bone diseases like OP.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Guoju Hong, Lin Zhou, Guanqiang Zheng, Xiaoxia Zheng, Zhenqiu Chen, Wei He, Qiushi Wei
Summary: Liquiritin (LIQ) has the ability to inhibit osteoclast formation and bone-resorbing activity induced by RANKL, and it exerts its effects by reducing ROS levels and suppressing the Ca2+/MAPK-NFATc1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Jiachao Guo, Ranyue Ren, Zhou Guo, Kai Sun, Jinpeng He, Jingfan Shao, Xiaolin Wang
Summary: Osteoporosis is a systemic and endocrine bone disorder characterized by decreased bone mineral density, compromised bone strength, and destruction of trabecular structure. The excessive osteoclastogenesis and bone erosion contribute to the progression of the disease. However, existing medications have poor adherence and adverse reactions, highlighting the urgent need for novel therapies for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Hao Qu, Yuankang Zhang, Rongxin He, Nong Lin, Cong Wang
Summary: Postmenopausal osteoporosis is a chronic systemic metabolic disease caused by excessive bone resorption and reduced bone formation. Anethole, a natural compound, shows potential in inhibiting osteoclast differentiation, reducing bone resorption, and suppressing osteoclast-specific gene expression through blocking ERK and AKT signaling pathways. Our study suggests that anethole may have osteoprotective effects and be a potential treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao Liu, Yining Li, Ren Sheng, Xiaowan Han, Li Bao, Chenyin Wang, Weizhi Wang, Xinhai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Yexiang Wu, Shunwang Li, Yu Ren, Yanni Xu, Shuyi Si
Summary: The study demonstrated that the N-methylpyridine-chlorofuranformamide analog 3i1 shows promise in upregulating OPG activity, inhibiting RANKL-induced osteoclastogenesis, and promoting osteoblast differentiation, potentially serving as a new therapeutic agent for osteoporosis.
BIOORGANIC CHEMISTRY
(2021)
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Article
Chemistry, Medicinal
Shuan-Jing Wang, Jiahui Zhang, Jing-Zan Zhang, Ruo-Nan Ning, Chen-Chen Li, Xing Xu, Min Jiang, Wen-Wei Qiu
Summary: A series of heterocyclic ring-fused derivatives of 20(S)-protopanaxadiol (PPD) were synthesized and evaluated for their inhibitory effects on RANKL-induced osteoclastogenesis. Compound 33 (SH491) showed the highest potency with 100% inhibition at 0.1 μM and 44.4% inhibition at 0.01 μM, surpassing the lead compound PPD. Cytotoxicity tests indicated that the inhibitory effect was not due to cytotoxicity, and SH491 also affected osteoblastogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Shipeng Zhou, Huimin You, Shuting Qiu, Dawei Yu, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease primarily caused by abnormal lipid metabolism and triglyceride accumulation in the liver. Nuclear receptors PPARα and FXR play a crucial role in the pathogenesis of NAFLD and are considered the most promising targets for treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Honglei Kang, Qian Guo, Yimin Dong, Renpeng Peng, Kehan Song, Jia Wang, Haiyang Liu, Meipeng Zhu, Hongjian Zhao, Hanfeng Guan, Feng Li
Summary: MAT2A is crucial for osteoclastogenesis and may be a potential therapeutic target for the treatment of osteoporosis.
Article
Immunology
Cong Xu, Shu-Qing Jin, Chen Jin, Zi-Han Dai, Yu-Hao Wu, Gao-Lu He, Hai-Wei Ma, Chao-Yi Xu, Wen-Lai Fang
Summary: The study aimed to investigate the effect and mechanism of Cedrol (Ced) in estrogen-deficient osteoporosis. The results demonstrated that Ced mitigated RANKL-induced osteoclastogenesis by reducing ROS content and inhibiting NFATc1, NF-KB, and MAPK signaling pathways. Additionally, Ced-mediated anti-osteolytic property was observed in ovariectomized mice. Thus, this study revealed the anti-osteoporotic potential of Cedrol in Ginger and provided more pharmacological evidence for Ginger as a food or medicine for bone metabolic disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Travers Sagar, Abe Kasonga, Ulrike Baschant, Martina Rauner, Shaakirah Moosa, Sumari Marais, Marlena Kruger, Magdalena Coetzee
JOURNAL OF FUNCTIONAL FOODS
(2020)
Editorial Material
Nutrition & Dietetics
Katie Schraders, Giancarla Zatta, Marlena Kruger, Jane Coad, Janet Weber, Louise Brough, Jasmine Thomson
Review
Biochemistry & Molecular Biology
Umani S. Walallawita, Frances M. Wolber, Ayelet Ziv-Gal, Marlena C. Kruger, Julian A. Heyes
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Matthew R. Miller, Marlena C. Kruger, Chris Wynne, Devonie Waaka, Weili Li, Chris Frampton, Fran M. Wolber, Charles Eason
Article
Chemistry, Multidisciplinary
Parkpoom Siriarchavatana, Marlena C. Kruger, Matthew R. Miller, Hong (Sabrina) Tian, Frances M. Wolber
APPLIED SCIENCES-BASEL
(2020)
Article
Nutrition & Dietetics
Christa Ellis, Herculina S. Kruger, Michelle Viljoen, Joel A. Dave, Marlena C. Kruger
Summary: The study found that changes in bone mineral density and bone resorption markers over two years were minimal in black postmenopausal women living with HIV. Despite a decrease in serum vitamin D, there were small or no changes in BMD and CTx over the 2-year period.
Article
Biochemistry & Molecular Biology
Cynthia Sithole, Carla Pieterse, Kayla Howard, Abe Kasonga
Summary: Osteoclasts are cells responsible for bone resorption, with GPR120 signaling possibly inhibiting their formation and resorption by suppressing ROS production. The GPR120 agonist TUG-891 can inhibit osteoclast formation and resorption by suppressing ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Keren E. Dittmer, Anastasia Chernyavtseva, Jonathan C. Marshall, Diana Cabrera, Frances M. Wolber, Marlena Kruger
Summary: Osteoporosis is a global public health issue, with approximately 3/4 of cases resulting from estrogen deficiency after menopause. This study used sheep as a model for osteoporosis and conducted experiments by performing ovariectomy and administering glucocorticoids. The results demonstrated that the expression of the klotho gene in the kidney showed the most significant difference in ovariectomized sheep treated with glucocorticoids for 2 months followed by a recovery period of 3 months. Klotho, known as the anti-aging hormone, is involved in the regulation of calcium and phosphorus metabolism, and it may play an important role in the recovery of bone mineral density in ovariectomized sheep treated with glucocorticoids for 2 months followed by euthanasia at 5 months.
Article
Biochemistry & Molecular Biology
Maryam Abshirini, Diana Cabrera, Karl Fraser, Parkpoom Siriarchavatana, Frances M. Wolber, Matthew R. Miller, Hong Sabrina Tian, Marlena C. Kruger
Summary: This study examined the changes in lipid and metabolite profiles of OVX rats with diet-induced MetOA after GSM supplementation using LC-MS metabolomics approach. Potential biomarkers for the effect of HFHS diet and GSM supplementation were identified, but further studies are needed for validation.
Article
Health Care Sciences & Services
Bolaji Lilian Ilesanmi-Oyelere, Nicole C. Roy, Marlena C. Kruger
Summary: This study aims to investigate the effects of synbiotic supplementation, exercise intervention, or a combination of both on gut microbiota, inflammation, and bone biomarkers in postmenopausal women. Recruitment of participants will begin in September 2021, with an anticipated completion date of June 2022. This will be the first randomized controlled trial to analyze the effects of both a synbiotic supplement and an exercise intervention in postmenopausal women.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Biochemistry & Molecular Biology
Ivana R. Sequeira, Marlena C. Kruger, Roger D. Hurst, Roger G. Lentle
Summary: This study developed an assay using a Shimadzu HPLC system to determine urinary lactulose and mannitol. The assay is simple, easy to use, and can be applied in routine clinical settings for quantification of intestinal permeability.
Article
Biochemistry & Molecular Biology
Bernice Asiedu, Busisani Wiseman Lembede, Monica Gomes, Abe Kasonga, Pilani Nkomozepi, Trevor Tapiwa Nyakudya, Eliton Chivandi
Summary: Alcohol consumption at different stages of development can lead to the development of alcohol-induced fatty liver disease (AFLD). Zingerone (ZO) has hepato-protective properties and when administered neonatally, it can provide protection against AFLD. This study aimed to evaluate the long-term protective effect of ZO against AFLD development.
Article
Nutrition & Dietetics
Marlena C. Kruger, Hajar Mazahery, Owen Mugridge, Sophie Turner, Pamela von Hurst
Summary: This study compared the effectiveness of deer milk (DM) and a commercially available oral nutritional supplement (ONS) for improving the nutritional status, muscle mass, and physical performance of older women. The results showed that DM may improve the nutritional status and physical performance of women at risk of malnutrition and/or with lower BMI, while also improving muscle mass in women with a higher BMI.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Maryam Abshirini, Jane Coad, Frances M. M. Wolber, Pamela von Hurst, Matthew R. R. Miller, Hong Sabrina Tian, Marlena C. C. Kruger
Summary: The study investigated the effects of whole meat GSM powder on gut microbiota abundance, body composition, and iron status markers in overweight or obese postmenopausal women. Forty-nine healthy postmenopausal women were randomly assigned to receive GSM powder or placebo for three months. The results showed no significant changes in gut microbiota abundance, body composition, and iron markers, except for a reduction in ferritin levels. However, there was a trend of increased abundance of Bacteroides and Bifidobacteria in the GSM group. These findings contribute to the knowledge of the effects of GSM powder in postmenopausal women.
JOURNAL OF NUTRITIONAL SCIENCE
(2023)
Review
Green & Sustainable Science & Technology
Matthew R. Miller, Maryam Abshirini, Frances M. Wolber, Te Rerekohu Tuterangiwhiu, Marlena C. Kruger
Summary: Greenshell mussels (GSMs) are a key aquaculture species in New Zealand and hold cultural and nutritional significance. They have attracted scientific attention due to their omega-3 fatty acids, which have anti-inflammatory properties and are being promoted for arthritis treatment. This review examines the composition, sustainability, and health benefits of GSMs, as well as the mechanisms behind their bioactive components.