Article
Biochemistry & Molecular Biology
Svetlana P. Chumakova, Olga I. Urazova, Vladimir M. Shipulin, Sergey L. Andreev, Olga A. Denisenko, Margarita V. Gladkovskaya, Larisa S. Litvinova, Mikhail A. Bubenchikov
Summary: This study aimed to investigate the angiopoietic endothelial dysfunction in ischemic cardiomyopathy (ICMP) patients. It was found that there was an imbalance in the number of endothelial progenitor cells (EPCs) and desquamated cells (EDCs) in ICMP patients. Additionally, alterations in the levels of HIF-1α, HIF-2α, ADMA, and endothelin-1 were observed in ICMP patients.
Review
Cardiac & Cardiovascular Systems
Nishant Johri, Prithpal S. Matreja, Shalabh Agarwal, Priya Nagar, Deepanshu Kumar, Aditya Maurya
Summary: This article aims to analyze the role of activated protein C (APC) in the pathogenesis of ischemic heart disease, heart failure, and myocardial ischemia-reperfusion injury, as well as discuss the potential of APC-based therapeutics.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Tobias Schroeper, Dennis Mehrkens, Veronika Leiss, Frederik Tellkamp, Stefan Engelhardt, Stefan Herzig, Lutz Birnbaumer, Bernd Nuernberg, Jan Matthes
Summary: In this study, we found that the deficiency of G alpha(i3) in mice overexpressing the cardiac beta(1)-adrenoceptor can slow or even prevent cardiomyopathy and increase lifespan.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Carlo A. Pivato, Rishi Chandiramani, Marija Petrovic, Johny Nicolas, Alessandro Spirito, Davide Cao, Roxana Mehran
Summary: Depression is common in patients with ischemic heart disease, and depressed patients are more likely to develop atherosclerosis and experience major cardiac events compared with the general population. The underlying pathophysiological mechanisms of these two diseases are highly interwoven and include an increased release of stress hormones, dysregulation of the autonomic nervous system, alterations of pathways related to primary and secondary hemostasis, endothelial dysfunction, and higher level of residual inflammation. Furthermore, depression negatively impacts compliance with medication regimens. Early recognition and treatment of depression provide the opportunity to improve outcomes of patients with ischemic heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Lourdes Vicent, Jose Guerra, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Luis Martinez Dolz, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Juan Delgado, Francisco Fernandez-Aviles, Manuel Martinez-Selles
Summary: This study aimed to investigate the impact of ischemic etiology on prognosis among men and women with heart failure. The results showed that ischemic etiology was not directly associated with mortality in HF patients, but was related to previous readmissions and chronic obstructive pulmonary disease in men, and diabetes in women in ischemic HF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Mary Audrey D. Viloria, Qing Li, Wang Lu, Nguyen Thanh Nhu, Yijie Liu, Zhen-Yang Cui, Yu-Jung Cheng, Shin-Da Lee
Summary: Exercise training has positive effects on cardiac mitochondrial respiration and quality control in patients with ischemic heart disease, including decreased reactive oxygen species production, increased mitochondrial activity, and improved biogenesis, dynamics, and mitophagy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Di Ren, Julia Fedorova, Kayla Davitt, Tran Ngoc Van Le, John H. Griffin, Patricia Chia-Ying Liaw, Charles Esmon, Alireza R. Rezaie, Ji Li
Summary: This study investigates the role of the APC-EPCR axis in ischemic insults in aging. The results show that APC activity is reduced during cardiac ischemia and reperfusion, and this reduction is more pronounced in aged hearts. Administration of APC prevents the shedding of EPCR induced by I/R and improves cardiac dysfunction in both young and aged mice. However, these cardioprotective effects of APC are diminished in EPCRR84A/R84A mice. AMPK mediates acute adaptive response while AKT is involved in chronic metabolic programming in APC-treated hearts.
CIRCULATION RESEARCH
(2022)
Letter
Cardiac & Cardiovascular Systems
Michael C. Honigberg, Ravi B. Patel, Ambarish Pandey, Gregg C. Fonarow, Javed Butler, Darren K. McGuire, Muthiah Vaduganathan
Summary: This study aims to evaluate the association of heart failure and ischemic heart disease with diabetes complications.
Review
Medicine, General & Internal
Luca Fazzini, Ludovica Caggiari, Martino Deidda, Carlotta Onnis, Luca Saba, Giuseppe Mercuro, Christian Cadeddu Dessalvi
Summary: Antiblastic drugs-induced cardiomyopathy is a significant cause of morbidity and mortality in chemotherapy patients. In recent years, researchers have focused on studying metabolic profiles in animals and humans to predict drug-induced cardiotoxicity and cardiovascular damage. In clinical practice, patients at risk of developing cardiotoxicity receive close monitoring and tailored therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Erij Messadi
Summary: Ischemic heart disease, particularly myocardial infarction, is a major cause of death worldwide. Snake venoms contain biologically active proteins and peptides that have potential therapeutic applications for treating ischemic heart disease and related conditions. This review discusses the mechanisms of action and therapeutic targets of snake venom toxins, as well as the current status of snake venom-derived drugs in clinical development.
Review
Biochemistry & Molecular Biology
Anurag Choksey, Kerstin N. Timm
Summary: The long-term cardiovascular complications of cancer therapy are increasing due to the rising number of cancer survivors. This article discusses the underexplored field of cancer therapy-induced cardiotoxicity (CTIC), which is caused by chemotherapy, targeted anti-cancer agents, and radiation therapy. The article emphasizes the need for diagnostics that can detect CTIC before functional decline occurs and reviews the metabolic alterations and mechanisms involved in the development of CTIC. The potential methods for diagnosing and predicting CTIC and the therapeutic potential of manipulating cardiac metabolism are also evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sahmin Lee, Hyo-Sook Hwang, Naaleum Song, Geun-Hyung Kang, Kyoung-Hee Choi, Eunhye Ji, Jong-Min Song, Duk-Hyun Kang
Summary: The study found that ARNI can effectively reduce functional mitral regurgitation (MR) and improve left ventricular reverse remodeling by modulating mechanisms such as endothelial-to-mesenchymal transition (EndoMT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Hao Yi-Dan, Zhao Ying-Xin, Yang Shi-Wei, Zhou Yu-Jie
Summary: This review discusses the role of high-energy phosphates in ischemic heart disease and the clinical evidence, highlighting the importance of exogenous creatine phosphate in cardioprotection. Although exogenous CrP has not been shown to improve long-term survival, it has beneficial effects on multiple secondary but important outcomes and short-term survival.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Giulia Querio, Susanna Antoniotti, Federica Geddo, Francesca Tullio, Claudia Penna, Pasquale Pagliaro, Maria Pia Gallo
Summary: Ischemic Heart Disease (IHD) is a clinical condition characterized by insufficient blood flow to the cardiac tissue, with distinct mechanisms of onset and progress between female and male patients. Estrogenic hormonal setting is highlighted as a key factor of sex-dependent divergences, affecting microvascular health and predisposing to vascular dysfunctions. Cardioprotective pathways activated by estrogen play a pivotal role, and understanding the estrogen receptors localization and function in the cardiovascular system is crucial in exploring these mechanisms.
VASCULAR PHARMACOLOGY
(2021)
Editorial Material
Cell Biology
Lea Montegut, Adrien Joseph, Hui Chena, Mahmoud Abdellatif, Christoph Ruckenstuhlg, Isabelle Martins, Frank Madeo, Guido Kroemer
Summary: DBI/ACBP is a conserved paracrine inhibitor that regulates autophagy and lifespan. Its increased levels in humans are associated with biological age and cardiovascular disease risk factors. Studies have shown that neutralizing DBI/ACBP can alleviate cardiac aging. Therefore, it may serve as a potential target for treating age-associated cardiovascular diseases.
Article
Cell Biology
Qingguo Lu, Jia Liu, Xuan Li, Xiaodong Sun, Jingwen Zhang, Di Ren, Nanwei Tong, Ji Li
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Xiaodong Sun, Fang Han, Qingguo Lu, Xuan Li, Di Ren, Jingwen Zhang, Ying Han, Yang K. Xiang, Ji Li
Article
Biochemistry & Molecular Biology
Ying Han, Weiju Sun, Di Ren, Jingwen Zhang, Zhibin He, Julia Fedorova, Xiaodong Sun, Fang Han, Ji Li
Article
Biochemistry & Molecular Biology
Di Ren, Nanhu Quan, Julia Fedorova, Jingwen Zhang, Zhibin He, Ji Li
Article
Biochemistry & Molecular Biology
Nanhu Quan, Xuan Li, Jingwen Zhang, Ying Han, Weiju Sun, Di Ren, Qian Tong, Ji Li
Review
Biochemistry & Molecular Biology
Jingwen Zhang, Di Ren, Julia Fedorova, Zhibin He, Ji Li
Article
Biochemistry & Molecular Biology
Di Ren, Zhibin He, Julia Fedorova, Jingwen Zhang, Elizabeth Wood, Xiang Zhang, David E. Kang, Ji Li
Summary: Sesn2, a stress-inducible protein, declines with aging in the heart. Lack of Sesn2 results in cardiac aging-like dysfunction and intolerance to ischemia reperfusion stress. Sesn2 deficiency impairs mitochondrial function and affects oxidative phosphorylation complex activity, impacting the maintenance of cardiac mitochondrial integrity.
Article
Cell Biology
Jingwen Zhang, Zhibin He, Julia Fedorova, Cole Logan, Lauryn Bates, Kayla Davitt, Van Le, Jiayuan Murphy, Melissa Li, Mingyi Wang, Edward G. Lakatta, Di Ren, Ji Li
Summary: SIRT1 and SIRT3 play critical roles in protecting cardiac function against ischemia/reperfusion injury by maintaining mitochondrial homeostasis, particularly mitochondrial dynamics. Deficiency of SIRT1 and SIRT3 results in impaired mitochondrial respiration and contractile function of cardiomyocytes under I/R stress, highlighting their importance in cardiac health.
Article
Cardiac & Cardiovascular Systems
Di Ren, Julia Fedorova, Kayla Davitt, Tran Ngoc Van Le, John H. Griffin, Patricia Chia-Ying Liaw, Charles Esmon, Alireza R. Rezaie, Ji Li
Summary: This study investigates the role of the APC-EPCR axis in ischemic insults in aging. The results show that APC activity is reduced during cardiac ischemia and reperfusion, and this reduction is more pronounced in aged hearts. Administration of APC prevents the shedding of EPCR induced by I/R and improves cardiac dysfunction in both young and aged mice. However, these cardioprotective effects of APC are diminished in EPCRR84A/R84A mice. AMPK mediates acute adaptive response while AKT is involved in chronic metabolic programming in APC-treated hearts.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew Kim, Azadeh Nikouee, Raymond Zou, Di Ren, Zhibin He, Ji Li, Lu Wang, Danijel Djukovic, Daniel Raftery, Hayley Purcell, Daniel Promislow, Yuxiao Sun, Mohammad Goodarzi, Qing-Jun Zhang, Zhi-Ping Liu, Qun Sophia Zang
Summary: This study demonstrates that TB-peptide, through activating Beclin-1, provides cardiac protection against endotoxemia in both young and aged populations. Metabolomics analysis suggests that the protective effect of TB-peptide, independent of age, is associated with reprogramming of energy production via glucose and amino acid metabolisms.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cell Biology
Meredith Krause-Hauch, Julia Fedorova, Linda Ines Zoungrana, Hao Wang, Mohammad Kasim Fatmi, Zehui Li, Migdalia Iglesias, Lily Slotabec, Ji Li
Summary: This study aims to explore the interconnection between Nrf2 and Sesn2 during obesity-related stress and its role in cardio-protection. The results showed that the overexpression of Sesn2 has cardio-protective effects on the obese heart by reducing ROS and fibrosis and improving cardiac function. Similar results were observed in human heart samples. However, there was no observable pattern of Sesn2/Nrf2 expression in mouse samples.
Article
Biochemistry & Molecular Biology
Ji Li, Tran Ngoc Van Le, Linda Ines Zoungrana, Hao Wang, Mohammad Kasim Fatmi, Di Ren, Meredith Krause-Hauch
Summary: SIRT1 plays a critical role in regulating substrate metabolism in the cardiovascular system. Cardiac SIRT1 can modulate substrate metabolism during pressure overload-induced heart failure by interfering with mitochondrial IDH2. Inhibition of SIRT1 activity benefits cardiac functions under pressure overload-related pathological conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Mohammad Kasim Fatmi, Di Ren, Julia Fedorova, Linda Ines Zoungrana, Hao Wang, Kayla Davitt, Zehui Li, Migdalia Iglesias, Edward J. Lesnefsky, Meredith Krause-Hauch, Ji Li
Summary: Ischemic heart disease (IHD) is the leading cause of death, with age being a major factor. Single-cell RNA sequencing was used to identify transcriptional differences between aged and young mice, providing insights into the vulnerability of the aged heart to ischemic insult.
Article
Cell Biology
Migdalia Iglesias, Hao Wang, Meredith Krause-Hauch, Di Ren, Linda Ines Zoungrana, Zehui Li, Jie Zhang, Jin Wei, Nikita Yadav, Kshama Patel, Mohammad Kasim Fatmi, Ruisheng Liu, Edward J. Lesnefsky, Ji Li
Summary: Acute kidney injury (AKI) leads to acute cardiac injury and dysfunction in cardiorenal syndrome Type 3 (CRS3) through oxidative stress (OS). The stress-inducible Sestrin2 (Sesn2) protein reduces reactive oxygen species (ROS) accumulation and activates AMP-dependent protein kinase (AMPK) to regulate cellular metabolism and energetics during OS. Sesn2 levels and its protective effects decline in the aged heart. Antidiabetic drug metformin upregulates Sesn2 levels in response to ischemia-reperfusion (IR) stress. However, the role of metformin in CRS3 remains unknown. This study seeks to explore how the age-related decrease in cardiac Sesn2 levels contributes to cardiac intolerance to AKI-induced insults, and how metformin ameliorates CRS3 through Sesn2.
