Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells

The ERK Pathway: Molecular Mechanisms and Treatment of Depression

(2019) John Q. Wang et al.   MOLECULAR NEUROBIOLOGY

P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

(2018) Mª José Queipo et al.   Frontiers in Molecular Neuroscience

Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer

(2018) Khairi Ahmad Muhammad et al.   Cancer Biology & Medicine

P2 receptor interaction and signalling cascades in neuroprotection

(2018) Mª Teresa Miras-Portugal et al.   BRAIN RESEARCH BULLETIN

The testosterone metabolite 3α-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism

(2018) Ari Loren Mendell et al.   NEUROSCIENCE LETTERS

Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases

(2017) Noopur Bhore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response

(2017) Olatz Arrizabalaga et al.   Oncogenesis

Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice

(2017) Sladjana Skopelja-Gardner et al.   Journal of Pain Research

Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients

(2016) Michael J. McCarthy et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Nucleotides in neuroregeneration and neuroprotection

(2016) M. Teresa Miras-Portugal et al.   NEUROPHARMACOLOGY

Pharmacology and structure of P2Y receptors

(2016) Ivar von Kügelgen et al.   NEUROPHARMACOLOGY

Deletion of Neurotrophin Signaling through the Glucocorticoid Receptor Pathway Causes Tau Neuropathology

(2016) Margarita Arango-Lievano et al.   Scientific Reports

Neuroprotection Mediated by P2Y 13 Nucleotide Receptors in Neurons

(2015) Raquel Pérez-Sen et al.   Computational and Structural Biotechnology Journal

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery

(2014) Verónica Morente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

Inhibition of mitogen-activated protein kinase phosphatase-1 (MKP-1) increases experimental stroke injury

(2014) Lin Liu et al.   EXPERIMENTAL NEUROLOGY

Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease

(2014) Louise M. Collins et al.   MOLECULAR NEUROBIOLOGY

A Genetic Mouse Model of Parkinson’s Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine

(2014) N. Brehm et al.   MOLECULAR NEUROBIOLOGY

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

(2014) M. Heiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting DUSPs in glioblastomas - wielding a double-edged sword?

(2013) Sheila Prabhakar et al.   CELL BIOLOGY INTERNATIONAL

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

(2013) D. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Spinal Mitogen-Activated Protein Kinase Phosphatase-3 (MKP-3) is Necessary for the Normal Resolution of Mechanical Allodynia in a Mouse Model of Acute Postoperative Pain

(2013) Madhurima Saha et al.   JOURNAL OF NEUROSCIENCE

Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons

(2013) Louise M. Collins et al.   NEUROMOLECULAR MEDICINE

Dual-Specificity MAP Kinase Phosphatases as Targets of Cancer Treatment

(2012) Caroline Nunes-Xavier et al.   Anti-Cancer Agents in Medicinal Chemistry

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation

(2012) Gopinath Krishnan et al.   GLIA

Caspase-3 Cleavage of DUSP6/MKP3 at the Interdomain Region Generates Active MKP3 Fragments That Regulate ERK1/2 Subcellular Localization and Function

(2012) Rocío Cejudo-Marín et al.   JOURNAL OF MOLECULAR BIOLOGY

Spinal Cannabinoid Receptor Type 2 Agonist Reduces Mechanical Allodynia and Induces Mitogen-Activated Protein Kinase Phosphatases in a Rat Model of Neuropathic Pain

(2012) Russell P. Landry et al.   JOURNAL OF PAIN

Mitogen Activated Protein Kinase Phosphatase-1 Prevents the Development of Tactile Sensitivity in a Rodent Model of Neuropathic Pain

(2012) Christian Ndong et al.   Molecular Pain

Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients

(2012) Andreas Menke et al.   NEUROPSYCHOPHARMACOLOGY

Are BDNF and glucocorticoid activities calibrated?

(2012) F. Jeanneteau et al.   NEUROSCIENCE

Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders

(2012) Hans O. Kalkman   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

(2012) S Cagnol et al.   ONCOGENE

DUSPs, to MAP kinases and beyond

(2012) Ching-Yu Huang et al.   Cell and Bioscience

Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation

(2011) Shunsuke Koga et al.   BRAIN RESEARCH

Protecting the stress response, guarding the MKP-1 mRNA

(2011) Yuki Kuwano et al.   CELL CYCLE

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways

(2011) Robin J. Dickinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual-specific Phosphatase-6 (Dusp6) and ERK Mediate AMPA Receptor-induced Oligodendrocyte Death

(2011) Maria Domercq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK1/2 activation is involved in the neuroprotective action of P2Y13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons

(2011) Felipe Ortega et al.   NEUROPHARMACOLOGY

Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats

(2011) Yunchun Chen et al.   NEUROSCIENCE LETTERS

Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas

(2011) S Messina et al.   ONCOGENE

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity

(2011) Se Hyun Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

(2010) O. Bermudez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

P2X7, NMDA and BDNF receptors converge on GSK3 phosphorylation and cooperate to promote survival in cerebellar granule neurons

(2010) Felipe Ortega et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death

(2010) Sami Reijonen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Differences in endoplasmic reticulum stress signalling kinetics determine cell survival outcome through activation of MKP-1

(2010) Bin Li et al.   CELLULAR SIGNALLING

Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning

(2010) John C. Dreixler et al.   EXPERIMENTAL EYE RESEARCH

Mechanisms of protein kinase D activation in response to P2Y2and P2X7 receptors in primary astrocytes

(2010) Luz MarÍa G. Carrasquero et al.   GLIA

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

(2010) Christopher J. Staples et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice

(2010) Zhidan Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition

(2010) Michal Hetman et al.   JOURNAL OF NEUROCHEMISTRY

Mkp1 Is a c-Jun Target Gene That Antagonizes JNK-Dependent Apoptosis in Sympathetic Neurons

(2010) M. Kristiansen et al.   JOURNAL OF NEUROSCIENCE

Keep the 'phospho' on MAPK, be happy

(2010) Schahram Akbarian et al.   NATURE MEDICINE

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching

(2010) Freddy Jeanneteau et al.   NATURE NEUROSCIENCE

Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids

(2010) Lauren E. Shipp et al.   PLoS One

Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells

(2009) Hsun-Jin Jan et al.   CANCER LETTERS

P2X7and P2Y13purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes

(2009) Luz María G. Carrasquero et al.   JOURNAL OF NEUROCHEMISTRY

CANnabinoid Receptor Type 2 Activation Induces a Microglial Anti-Inflammatory Phenotype and Reduces Migration via MKP Induction and ERK Dephosphorylation

(2009) Edgar Alfonso Romero-Sandoval et al.   Molecular Pain

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

P2X7 Nucleotide Receptor is Coupled to GSK-3 Inhibition and Neuroprotection in Cerebellar Granule Neurons

(2009) Felipe Ortega et al.   NEUROTOXICITY RESEARCH

Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells

(2008) Toru Furukawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within theDUSP6/MKP-3gene promoter

(2008) Maria Ekerot et al.   BIOCHEMICAL JOURNAL

Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism

(2008) Yu-Min Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation

(2008) Aleksandra Jurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons

(2008) M. Diaz-Hernandez et al.   JOURNAL OF CELL SCIENCE

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cisplatin-mediated activation of extracellular signal-regulated kinases 12 (ERK12) by inhibition of ERK12 phosphatases

(2008) Agata Gozdz et al.   JOURNAL OF NEUROCHEMISTRY

MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90

(2008) Y. Kuwano et al.   MOLECULAR AND CELLULAR BIOLOGY

Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway

(2008) O Bermudez et al.   ONCOGENE

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL