Synthesis and Anticancer Activity of Novel 9-O-Substituted Berberine Derivatives

A Natural Isoquinoline Alkaloid With Antitumor Activity: Studies of the Biological Activities of Berberine

(2019) Da Liu et al.   Frontiers in Pharmacology

Synthesis and anticancer activity of 9-O-pyrazole alkyl substituted berberine derivatives

(2018) Daipeng Xiao et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis of 9-Substituted Berberine Derivatives with Microwave Irradiation

(2018) Xie Han et al.   CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Berberine Derivatives with Different Pharmacological Activities via Structural Modifications

(2018) Daipeng Xiao et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability

(2018) Hong-Xin Cui et al.   MOLECULES

Development and In Vitro Evaluation of Linear PEI-Shelled Heparin/Berberine Nanoparticles in Human Osteosarcoma U-2 OS Cells

(2018) Hung-Kun Hsu et al.   MOLECULES

Assessment of Immunomodulatory Activities and in vitro Toxicity of New Quinolone 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h]quinoline-7-carboxylate

(2017) Soňa Jantová et al.   IMMUNOLOGICAL INVESTIGATIONS

Cancer Therapy Due to Apoptosis: Galectin-9

(2017) Koji Fujita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1

(2017) Fang Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synthesis and anti-inflammatory effects of a series of novel 9-O-substituted berberine derivatives

(2017) Zhenbao Liu et al.   MEDICINAL CHEMISTRY RESEARCH

Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

(2016) Kun Zou et al.   ACTA PHARMACOLOGICA SINICA

Synergy of 2-deoxy-d-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis

(2016) H. Dorota Halicka et al.   APOPTOSIS

Berberine inhibits androgen synthesis by interaction with aldo-keto reductase 1C3 in 22Rv1 prostate cancer cells

(2016) Jing Li et al.   ASIAN JOURNAL OF ANDROLOGY

Synthesis and hypoglycemic activity of 9- O -(lipophilic group substituted) berberine derivatives

(2016) Shanshan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Research progress on berberine with a special focus on its oral bioavailability

(2016) Chang-Shun Liu et al.   FITOTERAPIA

In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumoniae

(2016) Xiao-Yuan Zhou et al.   JOURNAL OF ANTIBIOTICS

Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells

(2016) Jingjing Gong et al.   MOLECULAR CARCINOGENESIS

Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis

(2016) YUWAN ZHAO et al.   ONCOLOGY REPORTS

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway

(2016) Jiwei Wang et al.   Oncotarget

Effect of new berberine derivatives on colon cancer cells

(2015) Luis Miguel Guamán Ortiz et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway

(2015) Qiaoyun Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effects of Berberine on Cell Cycle, DNA, Reactive Oxygen Species, and Apoptosis in L929 Murine Fibroblast Cells

(2015) Manman Gu et al.   Evidence-based Complementary and Alternative Medicine

Pharmacological effects of berberine and its derivatives: a patent update

(2015) Yifeng Jin et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil

(2015) Arvind Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Induction of G2/M Arrest by Berberine via Activation of PI3K/Akt and p38 in Human Chondrosarcoma Cell Line

(2015) Seong-Hui Eo et al.   ONCOLOGY RESEARCH

Resonance driven regioselective demethylation of berberine. Microwave assisted synthesis of berberrubine and its assessment as fluorescent chemosensor for alkanes

(2015) Arantzazu Delgado-Camón et al.   TETRAHEDRON

Inhibitory effects of emodin, baicalin, schizandrin and berberine onhefAgene: Treatment ofHelicobacter pylori-induced multidrug resistance

(2015) Yan-Qiang Huang   WORLD JOURNAL OF GASTROENTEROLOGY

A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region

(2015) Yun-Xia Xiong et al.   Oncotarget

Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats

(2014) Keke Chen et al.   APOPTOSIS

Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics

(2014) Renjun Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines

(2014) S.H. Park et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Experimental and theoretical studies on the molecular properties of ciprofloxacin, norfloxacin, pefloxacin, sparfloxacin, and gatifloxacin in determining bioavailability

(2014) E. Kłosińska-Szmurło et al.   JOURNAL OF BIOLOGICAL PHYSICS

Berberine induces selective apoptosis through the AMPK-mediated mitochondrial/caspase pathway in hepatocellular carcinoma

(2013) XIAOLONG YANG et al.   Molecular Medicine Reports

Progress in Microwave-Aided Chemical Synthesis

(2012) Hani Mutlak A. Hassan et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: A lipophilic substitute role

(2012) Chih-Yu Lo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dynamics of Singlet Oxygen Generation by DNA-Binding Photosensitizers

(2012) Kazutaka Hirakawa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

(2012) Lihong Wang et al.   PLoS One

Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro

(2012) NANNAN TONG et al.   Oncology Letters

Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

(2011) Z.-J. Huang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Oxidation of 4-substituted TEMPO derivatives reveals modifications at the 1- and 4-positions

(2011) David L. Marshall et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Berberine Inhibits Human Hepatoma Cell Invasion without Cytotoxicity in Healthy Hepatocytes

(2011) Bing Liu et al.   PLoS One

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

(2010) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

(2009) Yiyi Sun et al.   ANTI-CANCER DRUGS

Thermal generation of stable spin trap adducts with super-hyperfine structure in their EPR spectra: An alternative EPR spin trapping assay for radical scavenging capacity determination in dimethylsulphoxide

(2009) Michal Zalibera et al.   FREE RADICAL RESEARCH

The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

(2009) Jung-Mu Hur et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Berberine Targets Assembly of Escherichia coli Cell Division Protein FtsZ†

(2008) Prerna N. Domadia et al.   BIOCHEMISTRY