Article
Gastroenterology & Hepatology
Kota Arima, Rong Zhong, Tomotaka Ugai, Melissa Zhao, Koichiro Haruki, Naohiko Akimoto, Mai Chan Lau, Kazuo Okadome, Raaj S. Mehta, Juha P. Vayrynen, Junko Kishikawa, Tyler S. Twombly, Shanshan Shi, Kenji Fujiyoshi, Keisuke Kosumi, Yoko Ogata, Hideo Baba, Fenglei Wang, Kana Wu, Mingyang Song, Xuehong Zhang, Charles S. Fuchs, Cynthia L. Sears, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Wendy S. Garrett, Curtis Huttenhower, Andrew T. Chan, Jonathan A. Nowak, Marios Giannakis, Shuji Ogino
Summary: This study found that a Western-style diet is associated with a higher incidence of colorectal cancer containing abundant pks(+) E coli, providing further support for a potential link between diet, the intestinal microbiota, and colorectal carcinogenesis.
Article
Cell Biology
Shaohua Li, Wei Fang, Jianfeng Zheng, Zhiqiang Peng, Biyue Yu, Chunhui Chen, Yuting Zhang, Wenli Jiang, Shuhui Yuan, Lingqiang Zhang, Xueli Zhang
Summary: This study revealed a novel glucose-related CRC subtype characterized by SFRP2 and THBS2, with poor prognosis but possible therapeutic benefits from immune and targeted therapies.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Dong Hang, Xiaosheng He, Ane Sorlie Kvaerner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci, Mingyang Song
Summary: The study found that sex hormones, particularly sex hormone-binding globulin (SHBG), may play a role in early colorectal carcinogenesis. High SHBG levels were associated with a lower risk of conventional adenomas, while high levels of free estradiol and free testosterone were associated with a higher risk of conventional adenomas.
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Sonja Berndt, Daniel D. Buchanan, Amanda J. Cross, Brenda Diergaarde, Steven J. Gallinger, Marc J. Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A. Jenkins, Yi Lin, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Syed H. Zaidi, John D. Potter, Jeffrey A. Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Ulrike Peters, Amanda Phipps, Shuji Ogino
Summary: This study analyzed 13,101 colorectal cancer cases and found a significant association between tumor location and molecular features. The detailed colonic location and tumor molecular features play an important role in the prognostication and precision medicine of colon cancer.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Rebecca L. Siegel, Nikita Sandeep Wagle, Andrea Cercek, Robert A. Smith, Ahmedin Jemal
Summary: Colorectal cancer is the second leading cause of cancer death in the United States. The incidence of CRC has slowed down, but it is shifting to a younger age, advanced stage, and left colon/rectum. Mortality from CRC has declined overall, but increased in individuals younger than 50 years and Native Americans younger than 65 years. Uncovering the reasons for rising incidence and improving access to screening and treatment are crucial in combating CRC.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Fenglei Wang, Tomotaka Ugai, Koichiro Haruki, Yi Wan, Naohiko Akimoto, Kota Arima, Rong Zhong, Tyler S. Twombly, Kana Wu, Kanhua Yin, Andrew T. Chan, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Liming Liang, Mingyang Song, Stephanie A. Smith-Warner, Xuehong Zhang, Edward L. Giovannucci, Walter C. Willett, Shuji Ogino
Summary: This study found that unhealthy plant-based diet enriched with refined grains and sugar is associated with an increased incidence of colorectal cancer (CRC), while a healthy plant-based diet rich in whole grains, fruits, and vegetables is associated with a decreased incidence of CRC, especially KRAS-wildtype CRC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Tomotaka Ugai, Juha P. Vayrynen, Mai Chan Lau, Jennifer Borowsky, Naohiko Akimoto, Sara A. Vayrynen, Melissa Zhao, Rong Zhong, Koichiro Haruki, Andressa Dias Costa, Kenji Fujiyoshi, Kota Arima, Kana Wu, Andrew T. Chan, Yin Cao, Mingyang Song, Charles S. Fuchs, Molin Wang, Jochen K. Lennerz, Kimmie Ng, Jeffrey A. Meyerhardt, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Summary: This hypothesis-generating study suggests potential differences in histopathologic lymphocytic reaction patterns, macrophages, and regulatory T cells in the tumor microenvironment based on age at diagnosis.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Food Science & Technology
Jinxin Li, Hao Zhang, Xijuan Yang, Ling Zhu, Gangcheng Wu, Xiguang Qi, Hui Zhang
Summary: This study investigated the carbonyl trapping activity of bound-polyphenol rich insoluble dietary fiber (BP-IDF) from different whole grains and its underlying mechanism. The black highland barley BP-IDF showed significant effects in scavenging carbonyls, particularly for methylglyoxal, glyoxal, acrolein, and malondialdehyde. Even after gastrointestinal digestion, the black highland barley BP-IDF still retained considerable trapping activity. The presence of bound polyphenols was found to contribute to the carbonyl scavenging capacity.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Naohiko Akimoto, Sonja Berndt, Hermann Brenner, Daniel D. Buchanan, Jenny Chang-Claude, Kenji Fujiyoshi, Steven J. Gallinger, Marc J. Gunter, Akihisa Hidaka, Michael Hoffmeister, Li Hsu, Mark A. Jenkins, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Rish K. Pai, Lori C. Sakoda, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Michael O. Woods, Syed H. Zaidi, John D. Potter, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Amanda I. Phipps, Ulrike Peters, Shuji Ogino
Summary: Early-onset colorectal cancer is on the rise, and the prevalence of certain tumor molecular characteristics varies along different subsites of the colon. Understanding these differences by age and tumor location is crucial for personalized patient management.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Mimi Ton, Nathaniel F. Watson, Arthur Sillah, Rachel C. Malen, Julia D. Labadie, Adriana M. Reedy, Stacey A. Cohen, Andrea N. Burnett-Hartman, Polly A. Newcomb, Amanda I. Phipps
Summary: The study found that colorectal cancer patients, especially those with rectal cancer, are more likely to experience sleep issues, such as changes in sleep patterns after diagnosis. This suggests that sleep-focused survivorship care may need to be adapted based on colorectal cancer site to provide appropriate support for patients.
Article
Nutrition & Dietetics
Fred Brouns
Summary: Phytate serves as a phosphate storage molecule in cereals and other plant foods. However, minerals chelated in phytate are not bio-available, which can lead to impaired micronutrient status and increased mortality. While reducing phytate content in food through processing can improve mineral availability, results from in vitro studies may not accurately reflect in vivo effects due to various factors. Therefore, the decision to consume grain-based foods should consider the benefits and drawbacks of phytate.
Article
Food Science & Technology
Xun Wei, Wei Yang, Jianhui Wang, Yong Zhang, Yaxuan Wang, Yan Long, Bin Tan, Xiangyuan Wan
Summary: This article analyzes the global publication characteristics, hotspots, and frontiers of whole grain health benefit research. It finds that the overall number of publications is increasing, with the United States being the main contributor. Observational studies, systematic reviews, and meta-analysis are the most commonly used research methods, and the focus is mainly on dietary fiber and bioactive substances. The development of whole grain foods and their optimal intake has become a hot topic, with the need to reach a consensus and retain taste and healthy nutrients in processing.
Article
Immunology
Naohiko Akimoto, Juha P. Vayrynen, Melissa Zhao, Tomotaka Ugai, Kenji Fujiyoshi, Jennifer Borowsky, Rong Zhong, Koichiro Haruki, Kota Arima, Mai Chan Lau, Junko Kishikawa, Tyler S. Twombly, Yasutoshi Takashima, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Jeffrey A. Meyerhardt, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Summary: Immature desmoplastic reaction and myxoid stroma are associated with lower densities of immune cells in the colorectal tumor microenvironment, which may influence cancer survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Joshua Demb, Lin Liu, Caitlin C. Murphy, Chyke A. Doubeni, Maria Elena Martinez, Samir Gupta
Summary: The incidence of young-onset colorectal cancer (YCRC) is increasing, and there may be an association between iron-deficiency anaemia (IDA), haematochezia, and YCRC in US Veterans aged 18-49. By comparing individuals with IDA or haematochezia to those without, the cumulative incidence and risk of YCRC can be assessed.
Review
Oncology
Mehmet Yalchin, Ann-Marie Baker, Trevor A. Graham, Ailsa Hart
Summary: Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are enrolled into a surveillance programme aimed at detecting dysplasia or early cancer. Current surveillance programmes are guided by clinical, endoscopic or histological predictors of colitis-associated CRC (CA-CRC). There has been significant progress in understanding predictors of disease progression and improvements in endoscopic technique and management, leading to a decrease in the incidence of CA-CRC over the past 50 years. However, there is still room for improvement in our molecular understanding of CA-CRC progression and better risk stratification for patients with IBD.
Article
Oncology
Mathew Vithayathil, Scott Smith, Mingyang Song
Summary: This study analyzed a large cohort of colonoscopy patients to characterize the epidemiological profiles of serrated polyps (SPs) and compare them to conventional adenomas. The study found differences in subsite distribution and prevalence of polyps among different age groups, which has implications for improving colonoscopy screening and surveillance, as well as understanding the etiological heterogeneity of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Oncology
Alaina M. Bever, Mingyang Song
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Naohiko Akimoto, Sonja Berndt, Hermann Brenner, Daniel D. Buchanan, Jenny Chang-Claude, Kenji Fujiyoshi, Steven J. Gallinger, Marc J. Gunter, Akihisa Hidaka, Michael Hoffmeister, Li Hsu, Mark A. Jenkins, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Rish K. Pai, Lori C. Sakoda, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Michael O. Woods, Syed H. Zaidi, John D. Potter, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Amanda I. Phipps, Ulrike Peters, Shuji Ogino
Summary: Early-onset colorectal cancer is on the rise, and the prevalence of certain tumor molecular characteristics varies along different subsites of the colon. Understanding these differences by age and tumor location is crucial for personalized patient management.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Yin Zhang, Mingyang Song, Yin Cao, A. Heather Eliassen, Brian M. Wolpin, Meir J. Stampfer, Walter C. Willett, Kana Wu, Kimmie Ng, Frank B. Hu, Edward L. Giovannucci
Summary: This study prospectively evaluated the association between early-onset and later-onset type 2 diabetes and the risk of early-onset and later-onset cancer. The results showed that early-onset type 2 diabetes was associated with an increased risk of early-onset total cancer, diabetes-related cancer, and obesity-related cancer, particularly among individuals with higher BMI at 18 years of age. Later-onset type 2 diabetes was also associated with a higher risk of later-onset total cancer, diabetes-related cancer, and obesity-related cancer. However, the risk attenuated with aging.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Article
Oncology
Ruiyi Tian, Brian Wiley, Jie Liu, Xiaoyu Zong, Buu Truong, Stephanie Zhao, Md Mesbah Uddin, Abhishek Niroula, Christopher A. Miller, Semanti Mukherjee, Brendan T. Heiden, Jingqin Luo, Varun Puri, Benjamin D. Kozower, Matthew J. Walter, Li Ding, Daniel C. Link, Christopher Amos, Benjamin L. Ebert, Ramaswamy Govindan, Pradeep Natarajan, Kelly L. Bolton, Yin Cao
Summary: This study prospectively examined the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer. It found that CH is independently associated with increased risk of lung cancer, regardless of known risk factors.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Sonja Berndt, Daniel D. Buchanan, Amanda J. Cross, Brenda Diergaarde, Steven J. Gallinger, Marc J. Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A. Jenkins, Yi Lin, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Syed H. Zaidi, John D. Potter, Jeffrey A. Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Ulrike Peters, Amanda Phipps, Shuji Ogino
Summary: This study analyzed 13,101 colorectal cancer cases and found a significant association between tumor location and molecular features. The detailed colonic location and tumor molecular features play an important role in the prognostication and precision medicine of colon cancer.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Dong Hang, Lu Wang, Zhe Fang, Mengxi Du, Kai Wang, Xiaosheng He, Neha Khandpur, Sinara L. Rossato, Kana Wu, Zhibin Hu, Hongbing Shen, Shuji Ogino, Andrew T. Chan, Edward L. Giovannucci, Fang Fang Zhang, Mingyang Song
Summary: The consumption of ultra-processed food (UPF) is found to have adverse effects on the risk of colorectal cancer (CRC) precursors, such as conventional adenomas and serrated lesions. Participants with higher UPF consumption have an increased risk of these precursors, even after adjusting for other factors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Kai Wang, Ola Olen, Louise Emilsson, Hamed Khalili, Jonas Halfvarson, Mingyang Song, Jonas F. Ludvigsson
Summary: This study examines the association between a history of inflammatory bowel disease (IBD) in first-degree relatives (FDRs) and the risk of colorectal cancer (CRC). The researchers conducted a case-control study in Sweden among 69,659 CRC cases and 343,032 non-CRC controls. They found that having FDRs with IBD history did not increase the risk of CRC. These findings suggest that extra screening for CRC may not be necessary in the relatives of IBD patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Peilu Wang, Mingyang Song, A. Heather Eliassen, Molin Wang, Teresa T. Fung, Steven K. Clinton, Eric B. Rimm, Frank B. Hu, Walter C. Willett, Fred K. Tabung, Edward L. Giovannucci
Summary: Analyses of various dietary patterns showed that adhering to low insulinemic, low inflammatory, or diabetes risk-reducing diets resulted in the largest risk reduction for cardiometabolic diseases and cancer in US men and women. The comparability of different dietary patterns in improving overall health remains to be determined.
Article
Biochemistry & Molecular Biology
Mingyang Song, Zheming Ying, Xixiang Ying, Lianqun Jia, Guanlin Yang
Summary: Two new alkaloid natural products were obtained from Portulaca oleracea L. Their structures were identified using various spectroscopic techniques, including 1D, 2D NMR, and UHPLC-ESI-QTOF/MS. Furthermore, these compounds showed anti-inflammatory and anticholinesterase activities.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Fang Fang, Ola Olen, Mingyang F. Song, Jonas Halfvarson, Bjorn Roelstraete, Hamed Khalili, Jonas Ludvigsson
Summary: In this study, individuals who underwent endoscopic biopsy with normal mucosa were followed up for a median of 10 years. The study found that these individuals had an elevated risk of inflammatory bowel disease (IBD) for at least 30 years. These findings imply the presence of a substantial symptomatic period before the diagnosis of IBD and emphasize the importance of considering the long-term risk of IBD in patients with symptoms but normal mucosa on gastrointestinal investigation.
Editorial Material
Medicine, General & Internal
Kehuan Lin, Mingyang Song, Edward Giovannucci
ANNALS OF INTERNAL MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Mingyang Song, Michael Bretthauer
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)