Review
Gastroenterology & Hepatology
Reena Khanna, Christopher Ma, Vipul Jairath, Niels Vande Casteele, Guangyong Zou, Brian G. Feagan
Summary: Poor correlation between symptoms and active luminal inflammation has been established in patients with Crohn's disease and ulcerative colitis, leading to the use of endoscopic assessment. However, the current endoscopic indices used for evaluation are not completely validated and have limitations for clinical use.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Paul Enck, Sibylle Klosterhalfen
Summary: This review focuses on the placebo and nocebo responses in gastrointestinal diseases, particularly in Crohn's disease (CD) and ulcerative colitis (UC). The analysis includes over 10,000 patients with CD and UC, discussing the impact of placebo responses on clinical improvement and maintenance of remission, as well as identifying mediators and moderators of the response. Differences and similarities in placebo responses between IBD and IBS are compared, alongside the discussion of the nocebo effect in transitioning from biologics to biosimilars in IBD management.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Peter Ott, Aftab Ala, Frederick K. Askari, Anna Czlonkowska, Ralf-Dieter Hilgers, Aurelia Poujois, Eve A. Roberts, Thomas Damgaard Sandahl, Karl Heinz Weiss, Peter Ferenci, Michael L. Schilsky
Summary: Improving the design and standardization of clinical trials for Wilson's disease is essential for better treatment comparisons and reducing the number of patients needed per trial in the future.
Review
Biochemistry & Molecular Biology
Giada Amodeo, Silvia Franchi, Giulia Galimberti, Benedetta Riboldi, Paola Sacerdote
Summary: Inflammatory bowel disease is a chronic inflammatory condition that affects the gastrointestinal tract. Despite advancements in treatment, the underlying cause of the disease remains unknown. Recent research suggests that targeting the prokineticin system may be a potential therapeutic strategy for this condition.
Article
Pharmacology & Pharmacy
Martina Tallarico, Caterina Palleria, Livia Ruffolo, Rocco Spagnuolo, Maria Diana Naturale, Adele Emanuela De Francesco, Caterina De Sarro, Rossella Romeo, Rita Citraro, Patrizia Doldo, Ludovico Abenavoli, Luca Gallelli, Francesco Luzza, Antonio Leo, Giovambattista De Sarro
Summary: This study aimed to evaluate the occurrence of adverse events and therapeutic failures in patients treated with biological agents for inflammatory bowel diseases and found that the rate of adverse events was low in the observed patients.
Review
Gastroenterology & Hepatology
Harris A. Ahmad, James E. East, Remo Panaccione, Simon Travis, James B. Canavan, Keith Usiskin, Michael F. Byrne
Summary: Artificial intelligence has the potential to improve clinical research in inflammatory bowel disease endoscopy. It can enhance the efficiency and accuracy of assessing endoscopic activity in patients with inflammatory bowel disease and the impact of therapeutic interventions. This review discusses the current state of endoscopic assessment in inflammatory bowel disease clinical trials, highlighting the potential for artificial intelligence to transform the current paradigm and suggesting steps for implementation. By incorporating artificial intelligence into quality evaluation and patient progress monitoring, precision endoscopy and clinical trial recruitment in inflammatory bowel disease can be advanced.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Medicine, General & Internal
Bahareh Sophia Khalilipour, Andrew S. Day, Kristin Kenrick, Michael Schultz, Kristina Aluzaite
Summary: This study found substantial diagnostic delays in pediatric patients with IBD and identified significant associations between longer total healthcare diagnostic delays and overall household income and higher self-reported barriers to accessing healthcare.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Luca Scarallo, Anne M. Griffiths
Summary: Antibodies targeting tumour necrosis factor have improved the treatment of paediatric inflammatory bowel disease. Understanding pharmacokinetics and therapeutic drug monitoring has led to increased efficacy and durability of response. Primary non-response is more common in ulcerative colitis, emphasizing the need for alternative biologic agents and oral small molecules.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Klaus Gottlieb, Marco Daperno, Keith Usiskin, Bruce E. Sands, Harris Ahmad, Colin W. Howden, William Karnes, Young S. Oh, Irene Modesto, Colleen Marano, Ryan William Stidham, Walter Reinisch
Summary: Central reading is crucial in inflammatory bowel disease clinical trials, with room for improvements in various aspects. Experts propose a theoretical framework for enhancing statistical power, emphasizing the importance of factors like training, bowel preparation, and video quality.
Review
Gastroenterology & Hepatology
Jasmijn Z. Jagt, Charlotte M. Verburgt, Ralph de Vries, Nanne K. H. de Boer, Marc A. Benninga, Wouter J. de Jonge, Johan E. van Limbergen, Tim G. J. de Meij
Summary: This systematic review provides evidence for distinct faecal metabolomic profiles in paediatric IBD, but results varied across studies possibly due to differences in study design and applied analytical techniques. Faecal metabolomics could provide more insight into host-microbial interactions in IBD, but further studies with standardized methodologies and reporting are needed.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Katarzyna Bak-Drabik, Michalina Malik, Karolina Gwozdziewicz, Anna Jarzumbek, Helena Krakowczyk, Monika Glowinkowska, Piotr Adamczyk
Summary: The aim of this study was to assess pulmonary function in children with inflammatory bowel disease (IBD). Differences in spirometric and oscillometry parameters were observed between the IBD group and the control group. However, there was no correlation between pulmonary function abnormalities and disease activity or immunosuppressive therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Stavros Koulizakos, Tina Kjellen, Karin Mellgren, Jenny M. Kindblom
Summary: The aim of this study is to describe experiences with budget preparations in paediatric clinical trials. 10 trials sponsored by the pharmaceutical industry were selected and the sponsor's initial budget was compared with the final budget. The findings indicate that thorough review and budget negotiation are essential to ensure equitable responsibility for the study-related costs and to avoid discontinuation of trials.
Article
Cell Biology
Kai Nie, Jun Yi, Yuanyuan Yang, Minzi Deng, Yan Yang, Tianyu Wang, Xuejie Chen, Zhaoyu Zhang, Xiaoyan Wang
Summary: The study found that m6A regulation plays a significant role in the occurrence and development of inflammatory bowel disease (IBD), influencing different subtypes and therapeutic responses in IBD. m6A modification involves methyltransferases, demethylases, and methylation-reading proteins, affecting the pathophysiology and clinical phenotypes of the disease through regulation of IBD risk genes and core cytokines.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Anna Buczynska, Urszula Grzybowska-Chlebowczyk, Krzysztof Pawlicki
Summary: This study analyzed the medical history of 292 newly diagnosed pediatric IBD patients and found that IgE sensitization is related to the clinical presentation of IBD, including disease behavior, nature, and certain laboratory parameters.
Article
Pediatrics
Gertrude van den Brink, Martha A. C. van Gaalen, Marieke Zijlstra, Lissy de Ridder, Christine J. van der Woude, Johanna C. Escher
Article
Gastroenterology & Hepatology
Lissy de Ridder, Amit Assa, Jiri Bronsky, Claudio Romano, Richard K. Russell, Nadeem A. Afzal, Almuthe C. Hauer, Daniela Knafelz, Paolo Lionetti, Caterina Strisciuglio, Gabor Veres, Harland Winter, Victorien M. Wolters, Malgorzata Sladek, Arnold G. Vulto, Jorge A. Dias
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2019)
Article
Gastroenterology & Hepatology
Martinus A. Cozijnsen, Assaf Ben Shoham, Ben Kang, Byung-Ho Choe, Yon Ho Choe, Maria M. E. Jongsma, Richard K. Russell, Frank M. Ruemmele, Johanna C. Escher, Lissy de Ridder, Sibylle Koletzko, Javier Martin-de-Carpi, Jeffrey Hyams, Thomas Walters, Anne Griffiths, Dan Turner
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Gionata Fiorino, Theodore Lytras, Lisa Younge, Catarina Fidalgo, Sofie Coenen, Maria Chaparro, Mariangela Allocca, Ian Arnott, Peter Bossuyt, Johan Burisch, Marjo Campmans-Kuijpers, Lissy de Ridder, Axel Dignass, Ciara Drohan, Roger Feakins, Daniela Gilardi, Jan Grosek, Evelyn Gross, Ailsa Hart, Susanna Jaghult, Konstantinos Katsanos, Sanna Lonnfors, Yves Panis, Marko Perovic, Marieke Pierik, Jordi Rimola, Hagit Tulchinsky, Javier P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2020)
Review
Gastroenterology & Hepatology
Dwight A. Winter, Maria E. Joosse, Saskia N. de Wildt, Jan Taminiau, Lissy de Ridder, Johanna C. Escher
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2020)
Article
Gastroenterology & Hepatology
Esther Orlanski-Meyer, Chani Topf-Olivestone, Oren Ledder, Iris Dotan, Lars Folmer-Hansen, Angelika Kindermann, Amit Assa, Kaija-Leena Kolho, Sanja Kolacek, Matthew W. Carroll, Caterina Strisciuglio, Marina Aloi, Richard Hansen, Dan Navon, Harland S. Winter, Victor M. Navas-Lopez, Lissy de Ridder, Francoise Smets, Batia Weiss, Dan Turner
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2020)
Article
Gastroenterology & Hepatology
Martine A. Aardoom, Maria M. E. Jongsma, Annick de Vries, Jasja Wolthoorn, Lissy de Ridder, Johanna C. Escher
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2020)
Article
Medicine, General & Internal
Rachel E. Harris, Marina Aloi, Lissy de Ridder, Nicholas M. Croft, Sibylle Koletzko, Arie Levine, Dan Turner, Gigi Veereman, Mattias Neyt, Laetitia Bigot, Frank M. Ruemmele, Richard K. Russell
Article
Pediatrics
Maria M. E. Jongsma, Dwight A. Winter, Hien Q. Huynh, Lorenzo Norsa, Seamus Hussey, Kaija-Leena Kolho, Jiri Bronsky, Amit Assa, Shlomi Cohen, Raffi Lev-Tzion, Stephanie Van Biervliet, Dimitris Rizopoulos, Tim G. J. de Meij, Dror S. Shouval, Eytan Wine, Victorien M. Wolters, Christine Martinez-Vinson, Lissy de Ridder
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Review
Gastroenterology & Hepatology
Esther Orlanski-Meyer, Martine Aardoom, Amanda Ricciuto, Dan Navon, Nicholas Carman, Marina Aloi, Jiri Bronsky, Jan Daebritz, Marla Dubinsky, Seamus Hussey, Peter Lewindon, Javier Martin De Carpi, Victor Manuel Navas-Lopez, Marina Orsi, Frank M. Ruemmele, Richard K. Russell, Gabor Veres, Thomas D. Walters, David C. Wilson, Thomas Kaiser, Lissy de Ridder, Anne Griffiths, Dan Turner
Summary: By surveying experts and conducting systematic reviews, key predictors for pediatric UC outcomes, including colectomy, acute severe colitis, and cancer, were identified. These predictions can be used for personalized treatment approaches, improving outcomes for pediatric UC patients.
Review
Gastroenterology & Hepatology
Amanda Ricciuto, Martine Aardoom, Esther Orlanski-Meyer, Dan Navon, Nicholas Carman, Marina Aloi, Jiri Bronsky, Jan Daebritz, Marla Dubinsky, Seamus Hussey, Peter Lewindon, Javier Martin De Carpi, Victor Manuel Navas-Lopez, Marina Orsi, Frank M. Ruemmele, Richard K. Russell, Gabor Veres, Thomas D. Walters, David C. Wilson, Thomas Kaiser, Lissy de Ridder, Dan Turner, Anne M. Griffiths
Summary: Through expert survey and literature review, predictors of poor outcomes in pediatric CD were identified, aiding in the development of treatment algorithms and planning future studies.
Article
Gastroenterology & Hepatology
Marieke Zijlstra, Maria M. E. Jongsma, Annick de Vries, Tiny Schaap, Karien Bloem, Lissy de Ridder
Summary: This study demonstrates that bloodspot technology is a patient-friendly alternative method to measure IFX blood levels in patients with pediatric inflammatory bowel disease.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Maria M. E. Jongsma, Martine A. Aardoom, Martinus A. Cozijnsen, Merel van Pieterson, Tim de Meij, Michael Groeneweg, Obbe F. Norbruis, Victorien M. Wolters, Herbert M. van Wering, Iva Hojsak, Kaija-Leena Kolho, Thalia Hummel, Janneke Stapelbroek, Cathelijne van der Feen, Patrick F. van Rheenen, Michiel P. van Wijk, Sarah T. A. Teklenburg-Roord, Marco W. J. Schreurs, Dimitris Rizopoulos, Michail Doukas, Johanna C. Escher, Janneke N. Samsom, Lissy de Ridder
Summary: In paediatric patients with moderate-to-severe Crohn's disease, starting with infliximab (IFX) as first-line treatment (FL-IFX) is more effective in achieving and maintaining remission compared to conventional treatment.
Article
Medicine, General & Internal
Martine A. Aardoom, Polychronis Kemos, Irma Tindemans, Marina Aloi, Sibylle Koletzko, Arie Levine, Dan Turner, Gigi Veereman, Mattias Neyt, Richard K. Russell, Thomas D. Walters, Frank M. Ruemmele, Janneke N. Samsom, Nicholas M. Croft, Lissy de Ridder