CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

(2016) Frank A. Schildberg et al.   IMMUNITY

The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment

(2016) Yonghao Cao et al.   NEUROLOGY

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

(2016) Katrin Klocke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Multiple sclerosis genetics

(2014) Stephen Sawcer et al.   LANCET NEUROLOGY

Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma

(2014) Edward J Gettings et al.   Multiple Sclerosis Journal

Towards error-free profiling of immune repertoires

(2014) Mikhail Shugay et al.   NATURE METHODS

Ipilimumab in patients with melanoma and autoimmune disease

(2014) Chrisann Kyi et al.   Journal for ImmunoTherapy of Cancer

Hypophysitis Caused by Ipilimumab in Cancer Patients: Hormone Replacement or Immunosuppressive Therapy

(2013) A. Lammert et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

The genetics of multiple sclerosis: an up-to-date review

(2012) Pierre-Antoine Gourraud et al.   IMMUNOLOGICAL REVIEWS

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Management of Immune-Related Adverse Events and Kinetics of Response With Ipilimumab

(2012) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial

(2008) V. Viglietta et al.   NEUROLOGY

Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome

(2008) D. T. Okuda et al.   NEUROLOGY