Review
Biochemistry & Molecular Biology
Takumi Kitamoto, Tetsuo Nishikawa
Summary: Hypertension caused by primary aldosteronism poses a greater risk of severe cardiovascular complications compared to essential hypertension. The discovery of the KCNJ5 somatic mutation and the presence of CYP11B2-positive aldosterone-producing micronodules have significantly advanced our understanding of the pathogenesis of primary aldosteronism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yule Chen, Hanjiang Wang, Ke Wang, Guodong Zhu, Zhishang Yang, Min Wang, Wenbin Song
Summary: By comparing the abundance of serum metabolites between APA and EHT patients, as well as pre- and postoperative APA patients, this study reveals that APA might participate in cardiovascular and metabolic diseases by regulating serum metabolites.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Peripheral Vascular Disease
Yuhong Yang, Martina Tetti, Twinkle Vohra, Christian Adolf, Jochen Seissler, Michael Hristov, Alexia Belavgeni, Martin Bidlingmaier, Andreas Linkermann, Paolo Mulatero, Felix Beuschlein, Martin Reincke, Tracy Ann Williams
Summary: APAs exhibit transcriptome differences of different sizes, with BEX1 showing higher expression in micro-APAs compared to macro-APAs, negatively correlated with APA diameter, and promoting cell survival by regulating ferroptosis.
Article
Peripheral Vascular Disease
Vin-Cent Wu, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Bertrand Chin-Ming Tan, Yen-Hung Lin, Tai-Shuan Lai, Yung-Ming Chen, Jeff S. Chueh
Summary: In patients with unilateral primary aldosteronism, the coexistence of aldosterone-producing micronodules/nodules may have a negative impact on clinical success, as these patients are more likely to have persistent hypertension post-adrenalectomy. This may be explained by the attenuated HTR2B-mediated PLC/IP3/Ca2(+) pathway in Group A adenomas, as revealed by pathway enrichment analysis based on RNA-seq data.
Article
Peripheral Vascular Disease
Shinji Kishimoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Aya Mizobuchi, Takahiro Harada, Takayuki Yamaji, Yu Hashimoto, Kenichi Yoshimura, Yukiko Nakano, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi
Summary: This study aimed to evaluate the effects of KCNJ5 mutation on vascular function and vascular structure in aldosterone-producing adenoma (APA) and the effects of adrenalectomy on these factors in APA patients with and without KCNJ5 mutation. The study found that APA patients had lower flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) compared to patients with essential hypertension (EHT). After adrenalectomy, FMD and NID significantly improved in APA patients with KCNJ5 mutation, while only NID improved in APA patients without KCNJ5 mutation.
HYPERTENSION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kang-Yung Peng, Hung-Wei Liao, Jeff S. Chueh, Chien-Yuan Pan, Yen-Hung Lin, Yung-Ming Chen, Peng-Ying Chen, Chun-Lin Huang, Vin-Cent Wu
Summary: Mutated KCNJ5 channel plays a crucial role in the pathogenesis of aldosterone-producing adenoma, disrupting potassium ion selectivity and increasing autonomous aldosterone production. Immunohistochemical and patch-clamp experiments confirmed the functional properties of the mutation, while macrolide antibiotics were ineffective in interfering with the aberrant electrophysiological properties induced by the mutation.
Article
Oncology
Hung-Wei Liao, Kang-Yung Peng, Vin-Cent Wu, Yen-Hung Lin, Shuei-Liong Lin, Wei-Chou Lin, Jeff S. Chueh
Summary: In this study, a novel somatic ATP2B3 K416_F418delinsN mutation was identified in a patient with primary aldosteronism (PA). The mutation resulted from a deletion from nucleotides 1248 to 1253, leading to increased aldosterone synthesis. The patient, a 53-year-old man with bilateral adrenal masses, achieved partial biochemical and hypertension remission after left unilateral adrenalectomy.
Article
Endocrinology & Metabolism
Kazuki Nakai, Katsunori Manaka, Junichiro Sato, Maki Takeuchi, Yuto Yamazaki, Hironobu Sasano, Yuya Tsurutani, Jun Saito, Tetsuo Nishikawa, Taroh Ri, Masaomi Nangaku, Noriko Makita
Summary: This study investigates the association between the size and aldosterone-producing ability of aldosterone-producing adenomas. The results suggest that larger tumors have higher aldosterone-producing ability, and there are differences in pathology and gene mutations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Medicinal
Lina Yin, Youtian Pan, Yuanyuan Xue, Xiaoli Chen, Taiyun You, Jiahui Huang, Qihao Xu, Qingzhong Hu
Summary: Inhibition of CYP11B1 is a promising therapy for diseases caused by excessive cortisol, and enantiomer discrimination provides clues for achieving selectivity. A designed compound showed highly potent and selective inhibition of CYP11B1, with minimal effect on CYP11B2 and other enzymes. The compound demonstrated significant reduction of plasma cortisol levels without interfering with aldosterone production.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Linghui Kong, Jin Zhang, Lei Dong, Jianzhong Xu, Ping-Jin Gao, Ji-Guang Wang, Limin Zhu
Summary: This case report describes a 29-year-old female patient who underwent complete adrenalectomy for left aldosterone-producing adenoma in 2004 and partial right adrenalectomy for recurrent primary aldosteronism in 2018. Sanger sequencing revealed that both left and right adenomas carried the same aldosterone-driver KCNJ5 gene mutation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kazuhiro Kobuke, Kenji Oki, Celso E. Gomez-Sanchez, Elise P. Gomez-Sanchez, Kiyotaka Itcho, Haruya Ohno, Gaku Nagano, Yoko Yoshii, Ryuta Baba, Takaya Kodama, Koji Arihiro, Noboru Hattori, Masayasu Yoneda
Summary: The study found that cell proliferation mediated by ATP1A1 mutation in APAs was more significant compared to non-functioning adrenocortical adenomas or KCNJ5 mutated APAs. ATP1A1-mutant cells showed a significant increase in cell number, DNA content, and S-phase population. The research demonstrated that NKAs were highly expressed in ATP1A1 mutant APAs, potentially contributing to cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Celso E. Gomez-Sanchez, Desmare van Rooyen, William E. Rainey, Kazutaka Nanba, Amy R. Blinder, Radhakrishna Baliga
Summary: Aldosterone-producing adenoma is a rare cause of hypertension in children. This study describes a novel somatic KCNJ5 p.I157S mutation in an aldosterone-producing adenoma from a 16-year-old black female. Prompt diagnosis and early identification of gene mutations can lead to appropriate therapy and reduce cardiovascular sequelae.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Jui-Hsiang Lin, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Chin-Ming Bertrand Tan, Yuh-Feng Lin, Hui-Wen Chiu, Yen-Hung Lin, Yung-Ming Chen, Jeff S. Chueh, Vin-Cent Wu
Summary: This study found that one-third of patients with unilateral primary aldosteronism (uPA) also had autonomous cortisol secretion (ACS). The presence of multiple aldosterone-producing nodules/micronodules (mAPN/mAPM) in these patients was associated with larger tumor sizes and the interaction between them. Transcriptome analysis and bioinformatics revealed the significance of the HSD3B7/CYP11B1 signaling pathway in uPA adenomas with surrounding mAPN/mAPM. Furthermore, patients with concomitant mAPN/mAPM had lower rates of biochemical success after surgery.
ENDOCRINE-RELATED CANCER
(2022)
Article
Medicine, General & Internal
Hai Cai, Shao-Ming Chen, Zhi-Bin Ke, Hang Chen, Jun-Ming Zhu, Ting-Ting Lin, Fei Huang, Yong Wei, Qing-Shui Zheng, Xue-Yi Xue, Xiong-Lin Sun, Ning Xu
Summary: By analyzing gene expression profiles, candidate genes related to APA and PA were identified, and some of them were further confirmed through external validation. These newly identified genes may contribute to unraveling the potential mechanisms and therapeutic targets for APA and PA.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Wenjuan Liu, Zhenqiang Li, Simeng Chu, Xiaoyao Ma, Xiaoying Wang, Min Jiang, Gang Bai
Summary: This study found that atractylenolide-I (AT-I) can selectively inhibit cytochrome P450 11B2 (CYP11B2), thereby reducing the production of aldosterone and showing significant therapeutic effects for treating hyperaldosteronism.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Gastroenterology & Hepatology
Kazuhide Matsumoto, Nao Fujimori, Yoshitaka Hata, Yosuke Minoda, Masatoshi Murakami, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Eikichi Ihara, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa
Summary: This study investigated the clinical characteristics of ampullary neuroendocrine neoplasms (NENs) and found distinct differences between ampullary NENs and pancreatic NENs, such as higher incidences of NEC and cholangitis in ampullary NENs. Furthermore, the study discovered identifiable distinctions between ampullary NETs and NECs through endoscopic findings.
DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa
Summary: This study investigated the region-specific role of the M-3 receptor in gastrointestinal motility using a novel positive allosteric modulator (PAM-369). The results showed that PAM-369 selectively potentiated the M-3 receptor without agonistic or antagonistic activity and increased small intestinal transit in mice. However, it had no effect on colonic transit. This study provides the first direct evidence of the different functional roles of the M-3 receptor between the small intestine and colon.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Surgery
Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa
Summary: Mucosal incision-assisted biopsy (MIAB) is a safe procedure with minimal impact on postoperative prognosis for sampling gastric subepithelial lesions (SELs). MIAB releases some tumor cells after damaging the SEL's pseudocapsule, but it does not significantly affect the 5-year disease-free survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Gastroenterology & Hepatology
Akihisa Ohno, Nao Fujimori, Toshiya Abe, Masafumi Nakamura, Yoshihiro Ogawa
Article
Endocrinology & Metabolism
Yujiro Nakano, Masanori Murakami, Kazunari Hara, Tatsuya Fukuda, Masato Horino, Akira Takeuchi, Yoshihiro Niitsu, Kumiko Shiba, Kazutaka Tsujimoto, Chikara Komiya, Minato Yokoyama, Kenji Ikeda, Takanobu Yoshimoto, Yasuhisa Fujii, Tetsuya Yamada
Summary: This study explores the effects of adrenalectomy or mineralocorticoid receptor antagonist treatment on the long-term renal function of primary aldosteronism patients with chronic kidney disease (CKD). The results indicate that treatment is safe and useful in preventing renal injury in stage 3 CKD patients with primary aldosteronism.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Naoya Otsubo, Tatsuya Fukuda, Genhin Cho, Fumiaki Ishibashi, Tetsuya Yamada, Koshiro Monzen
Summary: This study evaluated the predictive ability of various indices, including waist circumference, BMI, FLI, and TyG-BMI, for nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) in non-obese individuals, and found that FLI and TyG-BMI had a particularly high predictive ability for NAFLD and MAFLD.
Article
Endocrinology & Metabolism
Naoya Otsubo, Tatsuya Fukuda, Hiroko Beppu, Chisato Maki, Fumihiko Yasui, Tomohide Hanawa, Chise Sugita, Masanori Murakami, Tetsuya Yamada, Michinori Kohara, Sachiko Wakai
Summary: This study aimed to evaluate the antibody response in patients with type 2 diabetes infected with SARS-CoV-2 and investigate any differences between patients with known diabetes and those with newly diagnosed diabetes. The results showed that patients with type 2 diabetes had comparable antibody responses to patients without diabetes, but those with newly diagnosed diabetes had lower antibody production compared to those with known diabetes in the second week of the disease.
BMC ENDOCRINE DISORDERS
(2023)
Editorial Material
Genetics & Heredity
Toshihiro Tanaka
JOURNAL OF HUMAN GENETICS
(2023)
Article
Medicine, General & Internal
Tatsuya Fukuda, Akiko Fujii, Taro Akihisa, Naoya Otsubo, Masanori Murakami, Tetsuya Yamada, Chisato Maki
Summary: This retrospective observational study aimed to evaluate the association between diabetic peripheral neuropathy diagnosed using DPN-Check and urinary albumin excretion in Japanese patients with type 2 diabetes. The results showed that patients with DPN-Check-determined diabetic peripheral neuropathy had significantly higher urinary albumin excretion than those without.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Hiroko Beppu, Tatsuya Fukuda, Naoya Otsubo, Taro Akihisa, Tomoko Kawanishi, Toshie Ogawa, Yasutomo Abe, Mariko Endo, Tomohide Hanawa, Chise Sugita, Yoshiaki Kikkawa, Tetsuya Yamada, Sachiko Wakai
Summary: This study investigates the severity and mortality of pre-Omicron and Omicron strains of SARS-CoV-2, as well as the impact of vaccination. The results show that the mortality rate among HD patients decreased during the Omicron epidemic. HD was significantly associated with severe COVID-19 in both epidemics. Unvaccinated HD patients had a higher risk of reaching the study endpoint.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Multidisciplinary Sciences
Tetsuo Sasano, Kensuke Ihara, Toshihiro Tanaka, Tetsushi Furukawa
Summary: This study aimed to assess the risk of paroxysmal atrial fibrillation (PAF) and stroke using genetic analysis and circulating biomarkers, and found that a genetic risk score using 4 SNPs associated with AF could evaluate the risk of AF. Additionally, plasma cfDNA level could be used to assess the risk of stroke, with diagnostic value for patients with a history of stroke.
