Article
Pediatrics
Melike Mehves Kaplan, Tuba Kurt, Merve Cansu Polat, Muge Sezer, Zahide Ekici Tekin, Elif celikel, Vildan Gungorer, Niluefer Tekgoz, Cueneyt Karagol, Serkan Coskun, Nimet Oner, Banu Celikel Acar
Summary: The aim of this study was to assess the predictors of relapse in patients with oligoarticular juvenile idiopathic arthritis (oJIA) who achieved clinical remission off medication. A retrospective observational study was conducted on 126 patients who achieved remission off medication. The study found that the number of intraarticular corticosteroid injections (IACIs) and the length of follow-up were significantly related to relapse in oJIA patients who achieved remission off medication.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Miladi Saoussen, Makhlouf Yasmine, Boussaa Hiba, Fazaa Alia, Ben Abdelghani Kawther, Laatar Ahmed
Summary: Musculoskeletal ultrasound (MSUS) is an important tool in pediatric rheumatology for detecting subclinical disease activity and treating patients during the window of opportunity. However, its role in assessing remission in JIA patients is not well-defined. This systematic review analyzes published literature on MSUS in JIA patients in remission, finding that abnormal MSUS findings, such as subclinical synovitis and Power Doppler signal, are common even in remission. Further studies are needed to better understand the implications and develop a standardized scoring system.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Massimiliano Grassi, Judith Rickelt, Daniela Caldirola, Merijn Eikelenboom, Patricia van Oppen, Michel Dumontier, Giampaolo Perna, Koen Schruers
Summary: This study developed a machine learning algorithm to predict OCD remission after two years using easily accessible predictors in daily clinical practice. The algorithm showed a moderate predictive performance in test centers, with significant between-center variations. Important predictors included OCD severity, chronic course, medication use, and global functioning. Future studies will focus on improving predictive performance stability across clinical settings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Judith A. Smith, Ruben Burgos-Vargas
Summary: Some studies suggest that children with juvenile onset spondyloarthritis have a relatively poor outcome compared to other juvenile idiopathic arthritis categories, but new therapies such as TNF inhibitors offer hope for improving disease prognosis.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Takahiro Imaizumi, Julia Meyer, Manabu Wakamatsu, Hironobu Kitazawa, Norihiro Murakami, Yusuke Okuno, Taro Yoshida, Daichi Sajiki, Asahito Hama, Seiji Kojima, Yoshiyuki Takahashi, Mignon Loh, Elliot Stieglitz, Hideki Muramatsu
Summary: This study used machine learning algorithms to classify patients with Juvenile myelomonocytic leukemia (JMML) and predict their survival outcomes. The results demonstrated that the machine learning models had high accuracy in predicting patient survival, enabling rapid selection of appropriate treatment strategies following diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Federica Filosco, Alessandro Giallongo, Salvatore Leonardi, Venera Tomaselli, Patrizia Barone
Summary: This study aimed to assess predictors of remission in children with juvenile idiopathic arthritis (JIA) treated with intra-articular corticosteroid injection (IACI) as monotherapy or in combination with methotrexate. The results showed that early IACI is a strong predictor of remission.
MINERVA PEDIATRICS
(2023)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Joeri W. van Straalen, Martine van Stigt Thans, Nico M. Wulffraat, Sytze de Roock, Joost F. Swart
Summary: This study developed and validated a diagnostic prediction model that can distinguish between juvenile idiopathic arthritis (JIA) and chronic musculoskeletal pain syndrome (CMPS) based on patient-reported outcomes. The model showed good calibration and discrimination in predicting JIA diagnosis.
JOURNAL OF PEDIATRICS
(2022)
Article
Rheumatology
Mao Mizuta, Masaki Shimizu, Natsumi Inoue, Yasuhiro Ikawa, Yasuo Nakagishi, Ryuhei Yasuoka, Naomi Iwata, Akihiro Yachie
Summary: The study showed that serum IL-18 levels can be used to differentiate between s-JIA and other diseases, and monitoring IL-18 levels can help predict the disease course and assess remission in s-JIA.
Article
Pediatrics
Yi-Chieh Chen, Chiann-Yi Hsu, Ming-Chin Tsai, Lin-Shien Fu, Yung-Chieh Huang
Summary: This study investigated remission in pediatric-onset SLE. Up to 60.2% of patients achieved clinical remission after treatment, with 19% of patients achieving remission off GCs. Long-term remission is rarer in pediatric-onset SLE than in adult-onset SLE.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biotechnology & Applied Microbiology
Ayse Tanatar, Ozlem Akgun, Sengul Caglayan, Esra Baglan, Gulcin Otar Yener, Kubra Ozturk, Mustafa Cakan, Hafize Emine Sonmez, Betul Sozeri, Nuray Aktay Ayaz
Summary: This study aimed to investigate patients who experienced exacerbation after discontinuation of biological disease-modifying anti-rheumatic agents (bDMARDs) and identify risk factors associated with flare. A multicenter study evaluated 101 patients with systemic and non-systemic juvenile idiopathic arthritis (sJIA and non-sJIA) whose bDMARDs were ceased after remission. The lowest risk of flare was observed in children with sJIA, while the presence of certain factors such as antinuclear antibody positivity, earlier disease onset, long disease duration, and extended time from diagnosis to first biological onset were associated with flare in the non-sJIA group.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Rheumatology
Takayuki Kishi, William Warren-Hicks, Nastaran Bayat, Ira N. Targoff, Adam M. Huber, Michael M. Ward, Lisa G. Rider
Summary: The study examined a North American registry of JDM patients to investigate factors associated with corticosteroid discontinuation, complete clinical response, and remission. Results suggest that JDM patients can achieve favorable outcomes over several years, with corticosteroid discontinuation, complete clinical response, and remission being inter-related and influenced by various clinical features and myositis autoantibodies.
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Fatma Aydin, Nilgun Cakar, Tuba Kurt, Banu Celikel Acar, Elif Celikel, Zeynep Birsin Ozcakar, Fatos Yalcinkaya
Summary: This study investigated the outcome of intra-articular corticosteroid injection (IACI) treatment in juvenile idiopathic arthritis (JIA) patients and factors associated with remission of synovitis. The results showed that being less than 7 years old at disease onset and low initial C-reactive protein (CRP) levels were correlated with a longer remission period. The study suggests that IACI is particularly effective in patients with low initial CRP levels and younger than 7 years of age.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Gaelle Chedeville, Katherine McGuire, David A. Cabral, Natalie J. Shiff, Dax G. Rumsey, Jean-Philippe Proulx-Gauthier, Heinrike Schmeling, Roberta A. Berard, Michelle Batthish, Gordon Soon, Kerstin Gerhold, Tommy Gerschman, Alessandra Bruns, Ciaran M. Duffy, Lori B. Tucker, Jaime Guzman
Summary: This study aims to describe the frequency and severity of medication side effects (SEs) in children with Juvenile Idiopathic Arthritis (JIA) and their impact on health-related quality of life (HRQoL). The results show that two-thirds of children with JIA experience SEs within 1 year of diagnosis, which negatively affects their HRQoL.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Nutrition & Dietetics
Sarah L. Finch, Alan M. Rosenberg, Anthony J. Kusalik, Farhad Maleki, Elham Rezaei, Adam Baxter-Jones, Susanne Benseler, Gilles Boire, David Cabral, Sarah Campillo, Gaelle Chedeville, Anne-Laure Chetaille, Paul Dancey, Ciaran Duffy, Karen Watanabe Duffy, Jaime Guzman, Kristin Houghton, Adam M. Huber, Roman Jurencak, Bianca Lang, Ron M. Laxer, Kimberly Morishita, Kiem G. Oen, Ross E. Petty, Suzanne E. Ramsey, Johannes Roth, Rayfel Schneider, Rosie Scuccimarri, Elizabeth Stringer, Shirley M. L. Tse, Lori B. Tucker, Stuart E. Turvey, Michael Szafron, Susan Whiting, Rae S. M. Yeung, Hassan Vatanparast
Summary: This study compared vitamin D levels in children with JIA and healthy children, finding that children with JIA had higher vitamin D levels than healthy children, which was associated with more frequent use of vitamin D supplements. Low vitamin D levels in children with JIA were associated with indicators of greater inflammation.
NUTRITION RESEARCH
(2021)
Article
Pediatrics
Liane D. Heale, Kristin M. Houghton, Elham Rezaei, Adam D. G. Baxter-Jones, Susan M. Tupper, Nazeem Muhajarine, Susanne M. Benseler, Gilles Boire, David A. Cabral, Sarah Campillo, Gaelle Chedeville, Anne-Laure Chetaille, Paul Dancey, Ciaran Duffy, Karen Watanabe Duffy, Janet Ellsworth, Jaime Guzman, Adam M. Huber, Roman Jurencak, Bianca Lang, Ronald M. Laxer, Kimberly Morishita, Kiem G. Oen, Ross E. Petty, Suzanne E. Ramsey, Johannes Roth, Rayfel Schneider, Rosie Scuccimarri, Lynn Spiegel, Elizabeth Stringer, Shirley M. L. Tse, Lori B. Tucker, Stuart E. Turvey, Rae S. M. Yeung, Alan M. Rosenberg
Summary: Children with newly diagnosed JIA in Canada have lower levels of physical activity compared to healthy children. The decline in physical activity levels over time is associated with disease activity and increased disease-specific psychosocial stress.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Rheumatology
Molly J. Dushnicky, Catherine Campbell, Karen A. Beattie, Roberta Berard, Tania Cellucci, Mercedes Chan, Tommy Gerschman, Nicole Johnson, Lillian Lim, Nadia Luca, Paivi Miettunen, Kimberly A. Morishita, Jean-Philippe Proulx-Gauthier, Dax G. Rumsey, Heinrike Schmeling, Rosie Scuccimarri, Herman Tam, Jaime Guzman, Michelle Batthish
Summary: The COVID-19 pandemic has not significantly impacted the initial presentation of JIA and JIA-related research in Canada. There was no observed delay in time to presentation or increased severity at presentation. However, there was a decrease in registry enrollment during the pandemic.
Editorial Material
Rheumatology
Jaime Guzman, Ross E. Petty
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. The guideline emphasizes the importance of improving patient quality of life and involving patients and caregivers in decision-making. However, the evidence quality for all recommendations is low.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on specific types of JIA and treatment options. The recommendations are based on low-quality evidence and are conditional in nature.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This guideline provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Recommendations include physical therapy and occupational therapy interventions, a healthy diet, medication monitoring, immunizations, and shared decision-making with patients/caregivers.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Jennifer J. Y. Lee, Simon W. M. Eng, Jaime Guzman, Ciaran M. Duffy, Lori B. Tucker, Kiem Oen, Rae S. M. Yeung, Brian M. Feldman
Summary: This study compared the ILAR and PRINTO JIA classification criteria in a cohort of JIA patients. The results showed that a large proportion of JIA patients were unclassifiable using the PRINTO criteria, and the alignment with clinicobiologic subtypes and adult forms of arthritis was not as good as the ILAR criteria.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Kiem Oen, Karine Toupin-April, Brian M. Feldman, Roberta A. Berard, Cia'ran M. Duffy, Lori B. Tucker, Jiahao Tian, Dax G. Rumsey, Jaime Guzman
Summary: This study validates the JIA parent global assessment as a valid measure of health-related quality of life. Comparisons with other HRQoL measures show good construct validity. However, reliability estimates and measurement errors were unsatisfactory, likely due to the time interval between assessments. Causal pathway analysis confirms previous findings.
Article
Rheumatology
Jonathan Park, Michelle Batthish, Roberta A. Berard, Gaelle Chedeville, Jean-Philippe Proulx-Gauthier, Dax G. Rumsey, Lori B. Tucker, Stephanie Wong, Jaime Guzman
Summary: Canadian pediatric rheumatology practices were generally in line with the 2019 JIA guideline recommendations, except for the frequent use of oral MTX and infrequent direct escalation from NSAIDs to bDMARDs in sacroiliitis and enthesitis.
Article
Pediatrics
Tara McGrath, Jaime Guzman, Lori Tucker, Natalie J. Shiff, Maryna Yaskina, Susan Tupper, Dax G. Rumsey
Summary: Among newly diagnosed children with moderate pain in Juvenile Idiopathic Arthritis (JIA), female sex, lower overall quality of life, and higher enthesitis counts at baseline are predictors of the development of persisting pain.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Rheumatology
A. Chen, C. Mammen, J. Guzman, E. Al-Abadi, S. M. Benseler, R. A. Berard, D. Gerstbacher, M. Heshin-Bekenstein, S. Kim, M. Klein-Gitelman, P. P. Chavan, K. E. James, N. Martin, F. McErlane, C. Myrup, D. G. Noone, J. Raghuram, S. Shenoi, V Sivaraman, T. Tanner, R. S. M. Yeung, D. A. Cabral, K. A. Morishita
Summary: There is a lack of specific guidelines for optimal glucocorticoid dosing in pediatric ANCA-associated vasculitis (pAAV). This study found that lower glucocorticoid doses can reduce toxicity without reducing efficacy in pAAV-related renal disease. Higher glucocorticoid doses were associated with renal failure and plasmapheresis use, and adverse effects were high across all dosing groups. Glucocorticoid dosing did not associate with 12-month outcomes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
L. B. Tucker, I. Niemietz, P. Mangat, M. Belen, J. Tekano, D. A. Cabral, J. Guzman, K. M. Houghton, K. A. Morishita, M. O. Chan, A. Human, M. Sundqvist, K. L. Brown
Summary: The study evaluated the ethnic diversity of children with SAID in a multiethnic Canadian province. The results showed extensive multi-ethnic diversity with European and Asian heritage being the most common. Some specific ethnicities were over-represented in SAID patients, while Chinese descent was under-represented in the cohort.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)