Article
Biochemistry & Molecular Biology
Xianfeng Zeng, Xi Xing, Meera Gupta, Felix C. Keber, Jaime G. Lopez, Ying-Chiang J. Lee, Asael Roichman, Lin Wang, Michael D. Neinast, Mohamed S. Donia, Martin Wuhr, Cholsoon Jang, Joshua D. Rabinowitz
Summary: This study quantitatively examines the inputs and outputs of the mouse gut microbiome using isotope tracing, revealing systematic differences in nutrient use across different bacteria. Diet can shape the microbiome by promoting the growth of bacteria that preferentially use the ingested nutrients.
Review
Agriculture, Dairy & Animal Science
Tarique Hussain, Ghulam Murtaza, Dildar H. Kalhoro, Muhammad S. Kalhoro, Elsayed Metwally, Muhammad Chughtai, Muhammad U. Mazhar, Shahzad A. Khan
Summary: The interactions between gut microbiota and host metabolism have a significant impact on health, including metabolic regulation and reproductive hormonal function. Gut bacteria participate in steroid hormone metabolism through enzymes and play a crucial role in reproductive events. Environmental bacteria can degrade steroid hormones and their compounds to eliminate pollution.
Review
Biochemistry & Molecular Biology
Esma Karahmet Farhat, Emina Karahmet Sher, Amina Dzidic-Krivic, Ines Banjari, Farooq Sher
Summary: The human gut is a host for trillions of microorganisms known as the gut microbiota, and its composition can be influenced by various factors, particularly diet and nutrition. A diet rich in phytoestrogens can alter the gut microbiota composition. Phytoestrogens have shown potential in treating different types of cancers, such as breast cancer in women, due to their ability to decrease estrogen levels. This review summarizes recent findings on the interaction between phytoestrogens and gut microbiota and discusses their potential future application in breast cancer treatment.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Review
Biochemistry & Molecular Biology
Lingyun Lu, Xiaoxuan Chen, Yi Liu, Xijie Yu
Summary: Osteoporosis is closely related to gut microbiota, influencing bone metabolism balance. Perturbation of GM can disrupt bone remodeling balance, while GM metabolites may regulate bone turnover, providing new perspectives for the prevention and treatment of osteoporosis.
Review
Biochemistry & Molecular Biology
Silvia Maffei, Francesca Forini, Paola Canale, Giuseppina Nicolini, Letizia Guiducci
Summary: There is a strong connection between gut microbiota disturbance and increased risk of cardiometabolic disorders and cardiovascular disease. Dietary regimen plays a key role in determining the biodiversity of gut microbiota and dysbiosis can affect the overall health of the cardiovascular system. The interaction between sex hormones and gut microbiota influences disease susceptibility and sexual dimorphism observed in CVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Ye Tu, Xinyi Kuang, Ling Zhang, Xin Xu
Summary: Gut microbiota plays an important role in human health, especially in maintaining skeletal homeostasis. Recent evidence has shown the intercorrelations between gut microbiota, endocrine system, and bone metabolism. This review article discusses the complex interactions between gut microbiota and bone metabolism-related hormones, suggesting that the regulatory effect of gut microbiota on bone health via the endocrine system could provide a new approach for managing musculoskeletal disorders.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Endocrinology & Metabolism
Aline C. C. Fenneman, Eveline Bruinstroop, Max Nieuwdorp, Anne H. H. van der Spek, Anita Boelen
Summary: The gut is a target organ of thyroid hormone and gut microbiota play a role in TH metabolism. Disruption of gut microbial homeostasis is associated with autoimmune thyroid disease. Further research and clinical trials are needed to understand the cause-effect mechanisms and develop microbiota-based therapies.
Review
Immunology
Nahir Garabatos, Pere Santamaria
Summary: The composition of the gut microbiota is closely related to the development of various autoimmune diseases, including inflammatory bowel disease and multiple sclerosis. Antigenic mimicry and the impact on effector and regulatory T cells are important mechanisms involved in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Shanlong Tang, Yuxia Chen, Fuli Deng, Xiaowei Yan, Ruqing Zhong, Qingshi Meng, Lei Liu, Yong Zhao, Sheng Zhang, Liang Chen, Hongfu Zhang
Summary: XOS enhances gut barrier and modulates gut immunity by optimizing gut microbiota and their metabolites, with effects including suppressing pro-inflammatory cytokines, increasing beneficial microbes, and altering biological processes in gut cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Microbiology
Xuejing Lyu, Shaona Wang, Jiaxin Zhong, Lingzhu Cai, Yanhui Zheng, Ying Zhou, Ying Zhou, Qionghua Chen, Qiyuan Li
Summary: This study explored the relationship between the intestinal microbiota and the development of gestational diabetes mellitus (GDM) by profiling the microbiome of 54 pregnant women. The results showed significant changes in the abundances of operational taxonomic units (OTU) between GDM subjects and healthy counterparts, and identified 132 altered metabolic pathways in GDM. Two overrepresented metabolites, butyrate and mevalonate, were also identified as potential intermediates of the microbiota in GDM. Finally, the study validated the impacts of the intestinal microbiota on GDM by analyzing serum samples from an independent cohort.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiaoqiao Luo, Ruoyu Shi, Yutong Liu, Libo Huang, Wei Chen, Chengtao Wang
Summary: In this study, it was found that components in Huangjiu, especially histamine, can increase oxidative stress and inflammatory cytokines in the liver and serum of mice. The gut microbiota community is also affected, with an increase in lipopolysaccharide levels. The study suggests a possible relationship between gut microbiota and liver pyroptosis, and highlights the potential health risks associated with Huangjiu consumption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ben A. Kappel, Lorenzo De Angelis, Andreas Puetz, Marta Ballanti, Rossella Menghini, Nikolaus Marx, Massimo Federici
Summary: There is a link between gut microbiota and host cholesterol metabolism, and changes in gut microbiota may contribute to hypercholesterolemia. Treatment with antibiotics can increase serum cholesterol levels and potentially impact cardiovascular disease.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Applied
Bowei Zhang, Yingchuan Xu, Huan Lv, Wenwen Pang, Jin Wang, Hui Ma, Shuo Wang
Summary: This study investigated the intestinal pharmacokinetics of resveratrol in mice using HPLC-MS/MS and found that resveratrol and its metabolites were present in significant amounts in the entire intestinal tract and feces, with a peak concentration at 4 hours post-administration. The study also demonstrated the promotion of Lactobacillus reuteri growth by resveratrol-3-O-sulfate during in vitro fermentation and the up-regulation of tight junction and mucin-related proteins mRNA expressions by resveratrol-3-O-sulfate during incubation with Caco-2 cells.
Review
Biochemistry & Molecular Biology
Ana G. Abril, Monica Carrera, Angeles Sanchez-Perez, Tomas G. Villa
Summary: Food allergies have been increasing dramatically in developed countries. It is well-established that maintaining a specific microbial consortium in the gastrointestinal tract is crucial for food tolerance. Recent advances in '-omics' technologies and systems biology offer promising approaches to understand the relationship between gut microbiome and food allergies. This review summarizes the current knowledge in the field of food allergies and discusses the future advances that will be achieved by applying proteomic techniques to study the GI tract microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Nicolas Lucas, Romain Legrand, Christine Bole-Feysot, Jonathan Breton, Moise Coeffier, Kirsti Akkermann, Anu Jarv, Jaanus Harro, Pierre Dechelotte, Serguei O. Fetissov
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Pharmacology & Pharmacy
Serguei O. Fetissov, Tomas Hokfelt
CURRENT OPINION IN PHARMACOLOGY
(2019)
Article
Nutrition & Dietetics
Jonathan Breton, Romain Legrand, Najate Achamrah, Philippe Chan, Jean Luc do Rego, Jean Claude do Rego, Moise Coeffier, Pierre Dechelotte, Serguei O. Fetissov
Article
Endocrinology & Metabolism
Romain Legrand, Nicolas Lucas, Manon Dominique, Saida Azhar, Camille Deroissart, Marie-Anne Le Solliec, Julie Rondeaux, Severine Nobis, Charlene Guerin, Fatima Leon, Jean-Claude do Rego, Nicolas Pons, Emmanuelle Le Chatelier, S. Dusko Ehrlich, Gregory Lambert, Pierre Dechelotte, Serguei O. Fetissov
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Microbiology
Nicolas Lucas, Romain Legrand, Camille Deroissart, Manon Dominique, Saida Azhar, Marie-Anne Le Solliec, Fatima Leon, Jean-Claude do Rego, Pierre Dechelotte, Serguei O. Fetissov, Gregory Lambert
Article
Microbiology
Jonathan Breton, Justine Jacquemot, Linda Yaker, Camille Leclerc, Nathalie Connil, Marc Feuilloley, Pierre Dechelotte, Serguei O. Fetissov
Article
Nutrition & Dietetics
Alessio Molfino, Maria Ida Amabile, Giovanni Imbimbo, Alessandra Emiliani, Cesarina Ramaccini, Emilie Lahaye, Kuniko Takagi, Serguei O. Fetissov
Article
Neurosciences
Jacopo Troisi, Reija Autio, Thanos Beopoulos, Carmela Bravaccio, Federica Carraturo, Giulio Corrivetti, Stephen Cunningham, Samantha Devane, Daniele Fallin, Serguei Fetissov, Manuel Gea, Antonio Giorgi, Francois Iris, Lokesh Joshi, Sarah Kadzielski, Aletta Kraneveld, Himanshu Kumar, Christine Ladd-Acosta, Geraldine Leader, Arlene Mannion, Elise Maximin, Alessandra Mezzelani, Luciano Milanesi, Laurent Naudon, Lucia N. Peralta Marzal, Paula Perez Pardo, Naika Z. Prince, Sylvie Rabot, Guus Roeselers, Christophe Roos, Lea Roussin, Giovanni Scala, Francesco Paolo Tuccinardi, Alessio Fasano
Article
Nutrition & Dietetics
Pierre Dechelotte, Jonathan Breton, Clementine Trotin-Picolo, Barbara Grube, Constantin Erlenbeck, Gordana Bothe, Serguei O. Fetissov, Gregory Lambert
Summary: The study found that overweight subjects who took the probiotic strain Hafnia alvei HA4597(R) showed significantly improved weight loss, increased feeling of fullness, and reduced hip circumference after 12 weeks. Compared to the placebo group, more subjects in the HA group achieved a weight loss of at least 3%.
Review
Nutrition & Dietetics
Lyudmila Gromova, Serguei O. Fetissov, Andrey A. Gruzdkov
Summary: The global prevalence of metabolic diseases such as obesity, metabolic syndrome, and type 2 diabetes has been increasing in recent decades, with hyperglycemia being a characteristic feature often associated with overeating. Glucose absorption in the small intestine plays a physiological role in regulating blood glucose levels, and may be relevant to hyperphagia in metabolic diseases where changes in blood glucose levels regulate appetite. While inhibiting small intestinal glucose absorption is a potential target for treating hyperglycemia, a more complex approach is required for treating metabolic diseases due to the independent regulation of glucose absorption and appetite.
Article
Endocrinology & Metabolism
Zamira M. M. Muruzheva, Daniil S. S. Egorov, Margarita T. T. Absalyamova, Dmitrii S. S. Traktirov, Marina N. N. Karpenko, Serguei O. O. Fetissov
Summary: This study found that NTS-binding IgG is present in patients with Parkinson's disease and its plasma levels are associated with disease severity. The study also suggests a possible link between NTS-binding IgG and gut microbiota, although more research is needed to understand its functional significance and relevance to the pathophysiology of Parkinson's disease.
NEUROIMMUNOMODULATION
(2022)
Article
Neurosciences
Henning Vaeroy, Saloua Takhlidjt, Yamina Cherifi, Emilie Lahaye, Nicolas Chartrel, Serguei O. O. Fetissov
Summary: This study analyzed the plasma concentrations of 26RFa in individuals with different levels of anxiety and aggressive behavior. The results showed that inmates had higher levels of aggression and anxiety compared to controls. The plasma levels of 26RFa correlated positively with anxiety scores in both groups, suggesting a link between this neuropeptide and anxiety.
Editorial Material
Microbiology
Serguei O. Fetissov
Summary: The survival of gut microbiota depends on nutrients provided by the host through food intake. The co-evolution of gut bacteria and humans has shaped the interactions between their metabolisms, impacting host feeding behavior. Understanding the molecular pathways involved may lead to new therapeutic approaches for conditions with altered feeding behavior. The Special Issue on Gut Microbiota-Brain Axis in Regulation of Feeding Behavior covers autoprobiotics, metabolic diseases, and anorexia.
Article
Psychology, Clinical
Marion Nicol, Emilie Lahaye, Mouna El Mehdi, Jean-Luc do Rego, Jean-Claude do Rego, Serguei O. O. Fetissov
Summary: Chronic stress can lead to increased intake of sweets or sugar craving, which poses a risk for the development of eating disorders and obesity. This study examined the effects of two Lactobacillus strains on food and sucrose intake in mice during exposure to chronic mild stress.
EUROPEAN EATING DISORDERS REVIEW
(2023)