Metabolic remodeling contributes towards an immune-suppressive phenotype in glioblastoma

Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma

(2018) Pravin Kesarwani et al.   CLINICAL CANCER RESEARCH

Integrative cross-platform analyses identify enhanced heterotrophy as a metabolic hallmark in glioblastoma

(2018) Antony H Prabhu et al.   NEURO-ONCOLOGY

The interplay between metabolic remodeling and immune regulation in glioblastoma

(2017) Pravin Kesarwani et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014

(2017) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesis

(2017) Antony Prabhu et al.   NEURO-ONCOLOGY

OS10.3 Randomized Phase 3 Study Evaluating the Efficacy and Safety of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: CheckMate 143

(2017) D. A. Reardon et al.   NEURO-ONCOLOGY

Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions

(2016) María de Lourdes Mora-García et al.   Journal of Translational Medicine

The Role of Prostaglandin E 2 in Tumor-Associated Immunosuppression

(2016) Dingzhi Wang et al.   TRENDS IN MOLECULAR MEDICINE

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis

(2015) Antony Prabhu et al.   NEURO-ONCOLOGY

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tryptophan-Degrading Enzymes in Tumoral Immune Resistance

(2015) Nicolas van Baren et al.   Frontiers in Immunology

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

(2015) Robert D. Leone et al.   Computational and Structural Biotechnology Journal

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth

(2013) A. Prabhu et al.   CANCER RESEARCH

The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress

(2013) F. Sahm et al.   CANCER RESEARCH

Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis

(2013) M. Vitucci et al.   NEURO-ONCOLOGY

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism

(2012) P. Chinnaiyan et al.   CANCER RESEARCH

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

(2012) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes

(2011) Felipe Saldanha-Araujo et al.   Stem Cell Research

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE