Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-κB Signaling Pathways

(2018) Yung-Ting Hsiao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma

(2017) Yuh Baba et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin

(2017) Xiao Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox)

(2017) Aimei Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis

(2017) Wei Li et al.   Oncotarget

Deguelin inhibits epithelial-to-mesenchymal transition and metastasis of human non-small cell lung cancer cells by regulating NIMA-related kinase 2

(2017) Dejian Zhao et al.   Thoracic Cancer

Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma

(2017) Xinfang Yu et al.   EBioMedicine

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer

(2016) Andrew J. Robles et al.   BREAST CANCER RESEARCH AND TREATMENT

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway

(2016) Wen Zheng et al.   Oncology Letters

Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model

(2016) Nerea Rebolleda et al.   PLoS One

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

(2015) S.-C. Lee et al.   CANCER RESEARCH

Antitumor effects of deguelin on H460 human lung cancer cellsin vitroandin vivo: Roles of apoptotic cell death and H460 tumor xenografts model

(2015) Yu-Chieh Hsu et al.   ENVIRONMENTAL TOXICOLOGY

Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors

(2015) Ho Shin Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling

(2015) Yu-Peng Liu et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion

(2015) Minh Phuong Nguyen et al.   Oncotarget

Deguelin Induces Apoptosis by Targeting Both EGFR-Akt and IGF1R-Akt Pathways in Head and Neck Squamous Cell Cancer Cell Lines

(2015) Yuh Baba et al.   Biomed Research International

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Paclitaxel: biosynthesis, production and future prospects

(2014) Susan Howat et al.   New Biotechnology

Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells

(2014) ZHENGGUANG LI et al.   Oncology Letters

Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells

(2013) Rajeshwari R. Mehta et al.   CLINICAL & EXPERIMENTAL METASTASIS

Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells

(2013) Rajeshwari Mehta et al.   PLoS One

Molecular Mechanism of Deguelin in Anti-tumor Effect

(2012) Lu Wen et al.   Current Pharmaceutical Analysis

Deguelin, an Akt Inhibitor, Down-Regulates NF-κB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice

(2012) Hyoun Woo Kang et al.   DIGESTIVE DISEASES AND SCIENCES

Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis

(2012) Dong-Jo Chang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system

(2012) Ke Men et al.   Nanoscale

Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model

(2012) S R Boreddy et al.   ONCOGENE

Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway

(2011) Vijayalakshmi Thamilselvan et al.   INTERNATIONAL JOURNAL OF CANCER

An overview of the c-MET signaling pathway

(2011) Shawna Leslie Organ et al.   Therapeutic Advances in Medical Oncology

Caught in the Akt: Regulation of Wnt Signaling in the Intestine

(2010) Eric C. Anderson et al.   GASTROENTEROLOGY

Liposomal Encapsulation of Deguelin: Evidence for Enhanced Antitumor Activity in Tobacco Carcinogen-Induced and Oncogenic K-ras-Induced Lung Tumorigenesis

(2009) J. K. Woo et al.   Cancer Prevention Research

Deguelin Inhibits Growth of Breast Cancer Cells by Modulating the Expression of Key Members of the Wnt Signaling Pathway

(2009) G. Murillo et al.   Cancer Prevention Research

Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells

(2009) Rui Li et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy

(2008) W.-Y. Kim et al.   Cancer Prevention Research

Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography

(2007) Haoyu Ye et al.   JOURNAL OF CHROMATOGRAPHY A