Article
Dentistry, Oral Surgery & Medicine
Jie Liu, Nikos Mattheos, Chuanxi Deng, Cheng Su, Zekun Wang, Nanyu Luo, Hua Tang
Summary: Icariin benefits MRONJ by improving soft tissue wound area and empty bone lacuna ratio, while teriparatide activates RANKL expression and reduces bone necrosis area and empty lacuna ratio. These findings suggest potential therapeutic benefits for patients with MRONJ.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Hironobu Hata, Kenji Imamachi, Michihiro Ueda, Masashi Matsuzaka, Hiroaki Hiraga, Toshihisa Osanai, Toru Harabayashi, Katsuya Fujimoto, Satoshi Oizumi, Masato Takahashi, Kazuhito Yoshikawa, Jun Sato, Yutaka Yamazaki, Yoshimasa Kitagawa
Summary: The study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid for different types of cancer. The results showed that patients with shorter survival times did not develop MRONJ, and dentists need to be aware of prognosis-related factors to predict MRONJ risk for effective dental management planning.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Toxicology
Bhumrapee Srivichit, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Bisphosphonates are commonly used in the treatment of bone and joint diseases, but long-term use can lead to osteonecrosis. Osteonecrosis is characterized by cell death and impaired cell functions, with medication-related osteonecrosis of the jaw being the most concerning condition. In addition to surgical treatment, non-surgical interventions have been explored to mitigate bisphosphonate-induced osteonecrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Jessica Pepe, Nicola Napoli, Andrea Palermo, Christos Magopoulos, Aliya A. Khan, M. Carola Zillikens, Jean-Jacques Body
Summary: This study evaluates the differences of MRONJ among different patient categories and provides recommendations on how to mitigate the risk and optimally manage MRONJ. The results indicate that patients with advanced malignancies are at a higher risk for MRONJ compared to those with benign bone diseases, but the overall risk is considerably lower than the benefits of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Xiao-Hong Wu, Shi-Wei Chen
Summary: This report presents a case of multiple myeloma (MM) identified in a surgical specimen previously diagnosed as medication-related osteonecrosis of the jaw (MRONJ) in a patient with MM. The patient exhibited symptoms of both MRONJ and MM, suggesting that MM and MRONJ can occur simultaneously at the same site.
Article
Environmental Sciences
Guillermo Pardo-Zamora, Yanet Martinez, Jose Antonio Moreno, Antonio J. Ortiz-Ruiz
Summary: MRONJ is a rare and severe disease with unclear exact cause and potential multifactorial origins. A case series of three stage 2 MRONJ patients showed complete healing within 12 months of therapeutic protocol application, with radiography demonstrating slow but progressive healing with normal bone structure. Conservative treatment and minimally invasive surgical intervention are effective for stage 2 MRONJ, while application of PRF-L in refractory cases can improve outcomes in soft tissue healing and bone regeneration, though further research is needed to confirm effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Se Hwa Kim, Young-Kyun Lee, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Summary: The study aimed to estimate the incidence of osteonecrosis of the jaw (ONJ) in Korean osteoporosis patients treated with bisphosphonates (BPs) and identified clinical risk factors such as advanced age, diabetes, and rheumatoid arthritis that increase the risk for ONJ.
Article
Biotechnology & Applied Microbiology
Stephane Odet, Christophe Meyer, Camille Gaudet, Elise Weber, Julie Quenot, Stephane Derruau, Sebastien Laurence, Lisa Bompy, Marine Girodon, Brice Chatelain, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Narcisse Zwetyenga, Philippe Marchetti, Anne-Sophie Hatzfeld, David Toubeau, Fabienne Pouthier, Xavier Lafarge, Heinz Redl, Mathilde Fenelon, Jean-Christophe Fricain, Roberta Di Pietro, Charlotte Ledouble, Thomas Gualdi, Anne-Laure Parmentier, Aurelien Louvrier, Florelle Gindraux
Summary: The use of human amniotic membrane (hAM) can promote tissue regeneration and healing in patients with medication-related osteonecrosis of the jaw (MRONJ). By using cryopreserved hAM, MRONJ can be effectively treated, leading to improved quality of life for patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Fatima Regina Nunes de Sousa, Vanessa Costa de Sousa Ferreira, Conceicao da Silva Martins, Hugo Victor Dantas, Frederico Barbosa de Sousa, Virginia Claudia Carneiro Girao-Carmona, Paula Goes, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao
Summary: The study evaluated the effect of Zoledronic acid on orthodontic tooth movement and root and bone resorption, finding that it can reduce tooth movement and exhibit anti-resorptive effects.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Camille Gaudet, Stephane Odet, Christophe Meyer, Brice Chatelain, Elise Weber, Anne-Laure Parmentier, Stephane Derruau, Sebastien Laurence, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Mathilde Fenelon, Jean-Christophe Fricain, Narcisse Zwetyenga, David Hoarau, Remi Curien, Eric Gerard, Aurelien Louvrier, Florelle Gindraux
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a complication caused by anti-resorptive agents and anti-angiogenesis drugs. We reviewed the literature and designed a questionnaire to collect information on clinical practices. However, we found missing data and a lack of consensus.
Article
Dentistry, Oral Surgery & Medicine
Kijeong Lee, Ji Sung Lee, Jinkwon Kim, Huisong Lee, Yoonkyung Chang, Ho Geol Woo, Jin-Woo Kim, Tae-Jin Song
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jin-Woo Kim, Tae-Whan Seong, Sura Cho, Sun-Jong Kim
Article
Medicine, General & Internal
Soo-Hwan Byun, Sun-Hyun Kim, Sura Cho, Ho Lee, Ho-Kyung Lim, Ju-Won Kim, Ui-Lyong Lee, Wan Song, Sun-Jong Kim, Min-Kyoung Kim, Jin-Woo Kim
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Yoo-Lim Choi, Young-Eun Jang, Bom Sahn Kim, Jin-Woo Kim, Yemi Kim
Article
Clinical Neurology
Hyo-Jung Kim, JaeHan Park, Ji-Soo Kim
Summary: This review discusses recent advances in the diagnosis and management of Benign Paroxysmal Positional Vertigo (BPPV), including the use of web-based technology and artificial intelligence, as well as the evidence supporting the use of vitamin D supplements for patients with BPPV and subnormal serum vitamin D levels.
JOURNAL OF NEUROLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Young Long Park, Sura Cho, Jin-Woo Kim
Summary: This case involves a 71-year-old male with mucormycosis-induced maxillary osteonecrosis extending to the cranial base. After confirmation through biopsy, the patient underwent surgical intervention and showed full recovery at the 4-week follow-up. Proper diagnosis, timely treatment, and combination therapy are crucial in managing such cases.
Article
Endocrinology & Metabolism
Jung-Hyun Park, Sura Cho, Sun-Jong Kim, Tae-Dong Jeong, Yeung-Chul Mun, Jin-Woo Kim
Summary: This prospective study identified specific biomarkers (TRACP 5b and DKK1) with abnormal serum levels in patients at risk of ONJ, before and after dentoalveolar surgery. These biomarkers could be used for close monitoring to prevent and diagnose ONJ early.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Jin-Woo Kim, Jeong Yee, Sang-Hyeon Oh, Sun-Hyun Kim, Sun-Jong Kim, Jee-Eun Chung, Hye-Sun Gwak
Summary: The study identified a significant association between VEGFA polymorphisms and BRONJ occurrence, with age and duration of bisphosphonate exposure as important risk factors. Machine learning algorithms showed high predictive performance for assessing BRONJ risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ji-Hoi Kim, Jung-Hyun Park, Jin-Woo Kim, Sun-Jong Kim
Summary: Ultrasonography can be used to assess the capsular width in painful TMJs, which were found to be wider compared to painless TMJs. Capsular width is a risk factor for TMJ pain and is significantly correlated with pain scores, suggesting a potential link between pain intensity and widened capsular width.
Article
Environmental Sciences
Yoonkyung Chang, Jimin Jeon, Jin-Woo Kim, Tae-Jin Song, Jinkwon Kim
Summary: Oral diseases like periodontitis and dental caries can lead to systemic inflammation and obesity. The presence of periodontitis, dental caries, and tooth loss are associated with higher BMI, while frequent tooth brushing may be related to lower BMI. Further research is needed to explore the relationship between oral health behavior, dental disease, and obesity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Minji Kim, Jingwen Li, Sehyang Kim, Wonho Kim, Sun-Hyun Kim, Sung-Min Lee, Young Long Park, Sook Yang, Jin-Woo Kim
Summary: This study utilized preoperative simulation and 3D titanium printing to fabricate and place customized BAMP devices precisely for treating skeletal Class III malocclusion. The growth modification effect was successful, with decreased ANB difference and Wits appraisal after 2 years, indicating accurate placement of the devices at planned locations.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kang-Min Kim, Sehyang Kim, Hyun Hwang, Hey-Yun Kim, Dohyun Kim, Jung-Hyun Park, HyeRan Choo, Jin-Woo Kim
Summary: This case-control study examined the therapeutic effects of daily or weekly administration of teriparatide in the management of medication-related osteonecrosis of the jaw (MRONJ). The results showed that both daily and weekly injection groups had significantly faster healing compared to the control groups. Complete resolution of MRONJ was more likely in participants who received teriparatide injections.
Review
Cell Biology
Hyung-Jin Won, Jin-Woo Kim, Hyung-Sun Won, Jeong-Oh Shin
Summary: Palatogenesis is a complex process involving various morphogenetic events that form the palate. Disruptions in these processes often result in cleft palate, a congenital abnormality. Recent investigations have identified transcription factors and signaling pathways that regulate palatogenesis, providing insights into gene regulatory networks and facilitating the development of better treatments for cleft palate.
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Dentistry, Oral Surgery & Medicine
Kang-min Kim, Soo-young Choi, Jung-Hyun Park, Heon-Young Kim, Sun-Jong Kim, Jin-Woo Kim
Summary: The study aimed to determine the increase and retention rate of bone height or width in patients who received extensive bone augmentation and analyze factors affecting its prognosis and stability. The results showed that extensive bone augmentation achieved a significant increase in bone height or width, and the retention rate after 6 months was high. Moreover, surgery in the maxillary region was more successful than in the mandible, with a higher maintenance rate and fewer cases of dehiscence.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.