Article
Biochemistry & Molecular Biology
Zhongjun Chen, Tieping Fan, Xusheng Zhao, Zhichen Zhang
Summary: This study demonstrates that depleting SOX2 improves IS through the PVT1/miR-24-3p/STAT3 axis, which may expand our understanding of the mechanisms of the SOX2/PVT1/miR-24-3p/STAT3 axis and provide a reference for IS therapy.
MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ruiqi Xu, Mengnan Zeng, Yuanyuan Wu, Shengchao Wang, Beibei Zhane, Jingke Zhane, Yuxuan Kan, Benke Li, Bing Cao, Xiaoke Zheng, Weisheng Feng
Summary: The research demonstrated that SZYY inhibited melanoma growth through various mechanisms, improved cardiac function, promoted apoptosis and oxidative stress in tumor tissues, inhibited STAT3 signaling and angiogenesis, with active ingredients identified as loganin, rutin, triohimas C, and triohimas D.
ONCOTARGETS AND THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Chengnan Tian, Shuo Hu, Junjian Yu, Wentong Li, Peijun Li, Huanlei Huang
Summary: This study revealed that PVT1 promotes cardiac fibrosis by increasing HCN1 expression through sponging miR-145. These findings suggest that targeting PVT1 may be a potential therapeutic option for cardiac fibrosis and cardiac diseases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Neurosciences
Xiao-Na Zhu, Jie Li, Gao-Lin Qiu, Lin Wang, Chen Lu, Yi-Ge Guo, Ke-Xin Yang, Fang Cai, Tao Xu, Ti-Fei Yuan, Ji Hu
Summary: Lasker's award-winning drug propofol is found to actively bind to the dopamine transporter (DAT) and relieve anhedonia by increasing dopamine accumulation in the nucleus accumbens (NAc). This study demonstrates the therapeutic potential of propofol against anhedonia and calls for future clinical investigations.
Article
Biochemistry & Molecular Biology
Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Kim
Summary: The study found that LicA, a major active component of licorice, has anticancer activity against ovarian cancer cells. LicA inhibited cell viability and induced G2/M phase arrest in SKOV3 cells. LicA also induced apoptosis by increasing reactive oxygen species levels, reducing mitochondrial membrane potential, and promoting caspase activation and cytochrome c release. Furthermore, LicA reduced STAT3 protein levels and downstream signaling, suggesting its potential as an anti-cancer agent.
Article
Plant Sciences
Ke-Shen Qu, Ying Luo, Xiao-Ning Yan, Le Kuai, Yi Ru, Yue Luo, Jian-Kun Song, Wan-Li Ji, Bin Li, Meng Xing
Summary: This study elucidates the mechanism of QZLX mixture against psoriasis through network pharmacology analysis and experiments, showing that it alleviates epidermal inflammation by inhibiting the IL6/STAT3 signaling pathway, improves pathological characteristics, and inhibits keratinocyte hyperproliferation. The findings support the clinical use of QZLX mixture in treating psoriasis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lin Xin, Hao Lu, Chuan Liu, Fei Zeng, Yi-Wu Yuan, You Wu, Jin-Liang Wang, Deng-Zhong Wu, Li-Qiang Zhou
Summary: The study showed that under conditions of Met deficiency, the down-regulation of lncRNA PVT1 further demethylates the promoter of BNIP3, inhibiting the proliferation of gastric cancer cells by activating mitophagy.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xi Wang, Zhe Cheng, Lingling Dai, Tianci Jiang, Pengfei Li, Liuqun Jia, Xiaogang Jing, Lin An, Meng Liu, Shujun Wu, Yu Wang
Summary: The study found that in non-small cell lung cancer, PVT1 promotes the proliferation, migration, and invasion of tumor cells by regulating miR-551b and FGFR1.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Ying Chen, Fangxuan Li, Dan Li, Wenxin Liu, Lei Zhang
Summary: The study found that the expressions of PVT1 and PD-L1 were significantly higher in cisplatin resistant epithelial ovarian cancer, and there was a positive correlation between them, with higher expressions associated with more malignant clinical behavior and shorter survival period.
CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Zhenqiang Wang, Xinjing Wang, Tianqi Zhang, Liping Su, Bingya Liu, Zhenggang Zhu, Chen Li
Summary: MALAT1 promotes IL-6 secretion in GC cells by blocking autophagic flux, leading to cancer progression. Mechanistically, MALAT1 competitively interacts with ELAVL1 to stabilize PTEN mRNA and activate the AKT/mTOR pathway, impacting autophagic flux.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yongyan Bi, Jie Ji, Youxin Zhou
Summary: Recent studies have shown that lncRNA-PVT1 is significantly upregulated in glioma tissues and plays an important role in cell proliferation, migration, invasion, and angiogenesis. Up-regulation of lncRNA-PVT1 promotes glioma progression both in vitro and in vivo by regulating miR-1207-3p expression. Prediction software was used to identify the regulatory mechanisms of lncRNA-PVT1, miR-1207-3p, and HNF1B, which were validated using a dual-luciferase reporter gene system. This suggests that the lncRNA-PVT1/miR-1207-3p/HNF1B axis may serve as novel molecular targets for glioma prevention and treatment.
Article
Plant Sciences
Jian-Hua Liu, Chen Li, Liang Cao, Chang-Hong Zhang, Zhi-Hua Zhang
Summary: The study found that Cucurbitacin B (CuB) can regulate the proliferation and apoptosis of lung cancer cells by inhibiting the XIST/miR-let-7c/IL-6/STAT3 axis.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Chen, Kundong Zhang, Yuhan Yang, Zengya Guo, Xiaofeng Wang, Buwei Teng, Qian Zhao, Chen Huang, Zhengjun Qiu
Summary: This study found significantly downregulated HCP5 expression in gastric cancer tissues, and depletion of HCP5 facilitated cell proliferation, migration, and invasion. Moreover, MEF2A-mediated HCP5 exerted an anti-tumor effect in gastric cancer development through the miR-106b-5p/p21 axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
An Yang, Xin Liu, Ping Liu, Yunzhang Feng, Hongbo Liu, Shen Gao, Limin Huo, Xinyan Han, Jurong Wang, Wei Kong
Summary: The study demonstrated that UCA1 promotes cell proliferation and inhibits apoptosis in gastric cancer cells by sponging miR-145 to upregulate MYO6 expression. Targeting the UCA1/miR-145/MYO6 axis may offer a potential therapeutic strategy for gastric cancer.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Chemistry, Medicinal
Huichao Huang, Fangling Huang, Xujun Liang, Ying Fu, Zhe Cheng, Yan Huang, Zhuchu Chen, Yankun Duan, Yongheng Chen
Summary: In this study, it was discovered that afatinib enhances radio sensitivity in nasopharyngeal carcinoma (NPC) by inhibiting the CD44-Stat3 signaling pathway and the subsequent Epithelial-Mesenchymal Transition (EMT) process. Functional assays demonstrated that afatinib combined with radiation treatment significantly suppressed cell viability, migration, EMT process, and CD44-Stat3 activity in vitro and in vivo. Additionally, activation of Stat3 reversed the changes induced by afatinib, suggesting that afatinib reverses EMT process by blocking the CD44-Stat3 axis. Overall, this work reveals the molecular mechanism of afatinib as a radiation sensitizer and provides potential therapeutic strategies for NPC radiosensitization.
Article
Biochemistry & Molecular Biology
Meiyuan Yang, Xiaoli Tang, Zheng Wang, Xiaoqing Wu, Dong Tang, Daorong Wang
BIOSCIENCE REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Zheng Wang, Xiaoli Tang, Xiaoqing Wu, Meiyuan Yang, Daorong Wang
BIOSCIENCE REPORTS
(2019)
Review
Surgery
Jiajie Zhou, Rui Du, Liuhua Wang, Feng Wang, Dongliang Li, Guifan Tong, Wei Wang, Xu Ding, Daorong Wang
Summary: This study systematically evaluated the effectiveness and safety of the ERAS pathway in bariatric surgery, finding that ERAS intervention significantly reduced the length of hospital stay and incidence of postoperative nausea and vomiting, without significant differences in other outcomes compared to standard care.
Article
Oncology
Qi Zhang, Muhammad Ali, Yang Wang, Qian-Nan Sun, Xiao-Dong Zhu, Dong Tang, Wei Wang, Cang-Yuan Zhang, Hai-Hua Zhou, Dao-Rong Wang
Summary: The present study reveals that galectin-1 (Gal-1) and glucose-regulated protein 78 (GRP78) play important roles in the development of malignant gastric cancer (GC). High levels of Gal-1 and GRP78 expression are associated with poor prognosis in GC patients. Gal-1 interacts with GRP78 to facilitate the proliferation, migration, and invasion of GC, thus accelerating its progression.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Surgery
Muhammad Ali, Xiaodong Zhu, Yang Wang, Jianyue Ding, Qi Zhang, Qiannan Sun, Shantanu Baral, Daorong Wang
Summary: This study compared the short-term outcomes of robotic surgery and laparoscopic surgery in treating rectal cancer. The results showed that robotic surgery had better performance in terms of Clavien-Dindo classification, sepsis, and harvested lymph nodes, but it was also associated with higher cost.
FRONTIERS IN SURGERY
(2022)
Letter
Surgery
Jin Ji, Muhammad Ali, Mingrui Jiang, Daorong Wang
ASIAN JOURNAL OF SURGERY
(2023)
Letter
Surgery
Jianyue Ding, Muhammad Ali, Fanyu Zhao, Daorong Wang
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Yang Wang, Muhammad Ali, Qi Zhang, Qiannan Sun, Jun Ren, Wei Wang, Dong Tang, Daorong Wang
Summary: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. We discovered that the transcription factor ATF4 is significantly upregulated in GC and plays a crucial role in promoting the proliferation and invasion of GC cells through activating the Sonic Hedgehog pathway. Understanding the mechanism of ATF4 in gastric cancer may provide new insights for developing targeted therapies.
Article
Surgery
Muhammad Ali, Yang Wang, Wenhao Yu, Shantanu Baral, Ren Jun, Daorong Wang
Summary: Randomized research showed that robotic surgery is safe and beneficial for oncological purposes in the short term. This study aimed to investigate if older adults derive greater benefits from robotic surgery compared to younger adults in terms of short-term outcomes. A retrospective analysis was performed on all rectal cancer patients aged 70 years and above (older adults) and below 70 years (younger adults) who underwent resection from 2019 to 2022. Short-term post-operative outcomes, including bowel movement, hospital stay duration, sepsis, and lymph node harvest, were evaluated based on age. The key outcomes assessed were complications and grades III-IV according to the Clavien-Dindo scale. Of the 298 individuals treated for rectal cancer, 108 (36.6%) were older adults and 190 (63.4%) were younger adults. Among older adults, 45 (41.6%) underwent robotic surgery while 63 (58.3%) underwent laparoscopic surgery. Among younger adults, 85 (44.7%) underwent robotic surgery while 105 (55.2%) underwent laparoscopic surgery. The analysis demonstrated a significant difference (P < 0.05) in the Clavien-Dindo grading system, with a higher proportion of grade III-IV patients in the laparoscopic surgery group compared to the robotic surgery group. Both younger and older individuals experienced different benefits from robotic surgery compared to laparoscopic surgery in terms of major post-operative complications.
JOURNAL OF ROBOTIC SURGERY
(2023)
