Engineering quorum quenching enzymes: progress and perspectives

Machine learning-assisted directed protein evolution with combinatorial libraries

(2019) Zachary Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein homology model refinement by large-scale energy optimization

(2018) Hahnbeom Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting Momentum: From Biocatalysis to Advanced Synthetic Biology

(2018) Christoffel P.S. Badenhorst et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quorum-Sensing Systems as Targets for Antivirulence Therapy

(2018) Tom Defoirdt   TRENDS IN MICROBIOLOGY

Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

(2018) Olga Khersonsky et al.   MOLECULAR CELL

Optimisation of a high-throughput fluorescamine assay for detection of N-acyl-l-homoserine lactone acylase activity

(2018) Shereen A. Murugayah et al.   ANALYTICAL BIOCHEMISTRY

PfmA, a novel quorum-quenching N-acylhomoserine lactone acylase from Pseudoalteromonas flavipulchra

(2017) Na Liu et al.   MICROBIOLOGY-SGM

Progress in and promise of bacterial quorum sensing research

(2017) Marvin Whiteley et al.   NATURE

Effect of Quorum Quenching Lactonase in Clinical Isolates of Pseudomonas aeruginosa and Comparison with Quorum Sensing Inhibitors

(2017) Assia Guendouze et al.   Frontiers in Microbiology

Pitfalls associated with evaluating enzymatic quorum quenching activity: the case of MomL and its effect on Pseudomonas aeruginosa and Acinetobacter baumannii biofilms

(2017) Yunhui Zhang et al.   PeerJ

CADEE: Computer-Aided Directed Evolution of Enzymes

(2017) Beat Anton Amrein et al.   IUCrJ

Bifunctional quorum-quenching and antibiotic-acylase MacQ forms a 170-kDa capsule-shaped molecule containing spacer polypeptides

(2017) Yoshiaki Yasutake et al.   Scientific Reports

Engineering Soluble Human Paraoxonase 2 for Quorum Quenching

(2016) Xin Cathy Li et al.   ACS Chemical Biology

Fast, Continuous, and High-Throughput (Bio)Chemical Activity Assay forN-Acyl-l-Homoserine Lactone Quorum-Quenching Enzymes

(2016) Daniel Last et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

(2016) Adi Goldenzweig et al.   MOLECULAR CELL

Engineering of a thermostable esterase Est816 to improve its quorum-quenching activity and the underlying structural basis

(2016) Xiwen Liu et al.   Scientific Reports

Harnessing hyperthermostable lactonase from Sulfolobus solfataricus for biotechnological applications

(2016) Benjamin Rémy et al.   Scientific Reports

Quorum-Quenching and Matrix-Degrading Enzymes in Multilayer Coatings Synergistically Prevent Bacterial Biofilm Formation on Urinary Catheters

(2015) Kristina Ivanova et al.   ACS Applied Materials & Interfaces

Enzyme multilayer coatings inhibit Pseudomonas aeruginosa biofilm formation on urinary catheters

(2015) Kristina Ivanova et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Quorum quenching enzymes

(2015) Susanne Fetzner   JOURNAL OF BIOTECHNOLOGY

Expression, purification and immobilization of recombinant AiiA enzyme onto magnetic nanoparticles

(2015) Chirag Beladiya et al.   PROTEIN EXPRESSION AND PURIFICATION

A roadmap to directed enzyme evolution and screening systems for biotechnological applications

(2014) Ronny Martínez et al.   BIOLOGICAL RESEARCH

Effective Antifouling Using Quorum-Quenching Acylase Stabilized in Magnetically-Separable Mesoporous Silica

(2014) Byoungsoo Lee et al.   BIOMACROMOLECULES

Computational tools for designing and engineering enzymes

(2014) Jiri Damborsky et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Silencing the mob: disrupting quorum sensing as a means to fight plant disease

(2014) Yael Helman et al.   MOLECULAR PLANT PATHOLOGY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia

(2014) Sami Hraiech et al.   PLoS One

Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ

(2014) G. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox

(2013) Julien Hiblot et al.   PLoS One

Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil inPseudomonas aeruginosaclinical isolates

(2013) Rodolfo García-Contreras et al.   Pathogens and Disease

Development of a dry, stable and inhalable acyl–homoserine–lactone–acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections

(2012) Mariana Wahjudi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The cloning and characterization of one novel metagenome-derived thermostable esterase acting on N-acylhomoserine lactones

(2012) Xinjiong Fan et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Quorum quenching quandary: resistance to antivirulence compounds

(2011) Toshinari Maeda et al.   ISME Journal

Divergence and Convergence in Enzyme Evolution: Parallel Evolution of Paraoxonases from Quorum-quenching Lactonases

(2011) Mikael Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Phosphotriesterase-Like Lactonase fromSulfolobus solfataricusand Its Immobilization for Disruption of Quorum Sensing

(2010) Filomena S. W. Ng et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Directed Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase Superfamily

(2010) Jeng Yeong Chow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quorum sensing and bacterial biofilms

(2010) Jeroen S. Dickschat   NATURAL PRODUCT REPORTS

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

An exciting but challenging road ahead for computational enzyme design

(2010) David Baker   PROTEIN SCIENCE

Directed Evolution of a Quorum-Quenching Lactonase fromMycobacterium aviumsubsp.paratuberculosisK-10 in the Amidohydrolase Superfamily

(2009) Jeng Yeong Chow et al.   BIOCHEMISTRY

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

(2009) Cara A Tracewell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket

(2009) M. Bokhove et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Natural Lactonase and Promiscuous Phosphotriesterase Activities

(2008) Mikael Elias et al.   JOURNAL OF MOLECULAR BIOLOGY

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY