Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox

Catalytic Metal Ion Rearrangements Underline Promiscuity and Evolvability of a Metalloenzyme

(2013) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Correction to Structural Evidence of a Productive Active Site Architecture for an Evolved Quorum-quenching GKL Lactonase

(2012) Bo Xue et al.   BIOCHEMISTRY

Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1

(2012) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus

(2012) Julien Hiblot et al.   PLoS One

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

(2012) Nobuhiko Tokuriki et al.   Nature Communications

Characterisation of the organophosphate hydrolase catalytic activity of SsoPox

(2012) Julien Hiblot et al.   Scientific Reports

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization and preliminary X-ray diffraction analysis of the hyperthermophilicSulfolobus islandicuslactonase

(2011) Guillaume Gotthard et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Divergence and Convergence in Enzyme Evolution: Parallel Evolution of Paraoxonases from Quorum-quenching Lactonases

(2011) Mikael Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

(2011) Rinkoo D Gupta et al.   Nature Chemical Biology

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase

(2010) Luigia Merone et al.   BIORESOURCE TECHNOLOGY

Macromolecular Inhibition of Quorum Sensing: Enzymes, Antibodies, and Beyond

(2010) Neri Amara et al.   CHEMICAL REVIEWS

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers

(2010) Y. Ashani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Directed Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase Superfamily

(2010) Jeng Yeong Chow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quorum sensing and bacterial biofilms

(2010) Jeroen S. Dickschat   NATURAL PRODUCT REPORTS

Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus

(2009) Renda Hawwa et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Directed Evolution of a Quorum-Quenching Lactonase fromMycobacterium aviumsubsp.paratuberculosisK-10 in the Amidohydrolase Superfamily

(2009) Jeng Yeong Chow et al.   BIOCHEMISTRY

Functional Annotation and Three-Dimensional Structure of Dr0930 fromDeinococcus radiodurans, a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily†‡

(2009) Dao Feng Xiang et al.   BIOCHEMISTRY

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archaeon Sulfolobus solfataricus

(2009) Pompea Del Vecchio et al.   EXTREMOPHILES

Structure-Based and Random Mutagenesis Approaches Increase the Organophosphate-Degrading Activity of a Phosphotriesterase Homologue from Deinococcus radiodurans

(2009) Renda Hawwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

(2009) C. J. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

The social behaviours of bacterial pathogens

(2008) R. Popat et al.   BRITISH MEDICAL BULLETIN

Structural Basis for Natural Lactonase and Promiscuous Phosphotriesterase Activities

(2008) Mikael Elias et al.   JOURNAL OF MOLECULAR BIOLOGY