Review
Pharmacology & Pharmacy
Louise F. Kimura, Leonardo S. Novaes, Gisele Picolo, Carolina D. Munhoz, Chi W. Cheung, Rosana Camarini
Summary: This review discusses the role of inflammation as a major biological substrate and etiological factor of chronic pain and depression/anxiety, as well as the potential beneficial actions of environmental enrichment in chronic pain and comorbid depression/anxiety through its effects on microglia. Additionally, alternative interventions like environmental enrichment may improve treatment compliance and patient outcomes according to clinical guidelines.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Chunsen Xu, Miaomiao Hou, Liangxia Su, Ning Qiu, Fandong Yu, Xinhua Zou, Chunling Wang, Jianwei Wang, Yongfeng He
Summary: Environmental enrichment is an important aspect of animal welfare and can improve animal well-being. However, the effect of habitat enrichment on laboratory fish, particularly rare minnows, is poorly understood. This study investigated the effect of environmental enrichment on the growth, physiological status, and anxiety-like behavior of rare minnows. The results showed that there were no significant differences in growth, anxiety-like behavior, and dopamine levels between the control and enriched groups. However, the enriched group had higher cortisol and serotonin levels. This suggests that the living environment can influence rare minnows and that further studies should consider the effects of environmental enrichment.
Article
Agriculture, Dairy & Animal Science
Pamela Dare, Rosemary Strasser
Summary: The length of stay for some animals has increased due to the decrease in euthanization rates in US shelters. However, research on the effectiveness of enrichment items in buffering the effects of daily stressors in the shelter environment is lacking. This study found that calming enrichment items, especially those with calming scent, were associated with lower stress levels in dogs during the daily stressor of kennel cleaning.
Article
Agriculture, Dairy & Animal Science
Francoise Pol, Adeline Huneau-Salaun, Sarah Gallien, Yannick Ramonet, Nicolas Rose
Summary: The algae-based cylinder enrichment material did not have any negative effects on pig health, performance, or body condition, and did not significantly improve pig welfare compared to metal chains. Despite being categorized as suboptimal, algae cylinders showed similar results to metal chains and wood logs in terms of welfare indicators.
Article
Agriculture, Dairy & Animal Science
Julia Eidsmo, Lone Madsen, Lars-Flemming Pedersen, Alfred Jokumsen, Manuel Gesto
Summary: Enriching the living environment of captive fish can improve their welfare, but studies on the feasibility of implementation in real farming scenarios are limited. This study tested the feasibility of using plastic shelters to improve rainbow trout welfare in an organic fish farm. The shelters had no negative effects on fish performance, health, or mortality, but there were no clear shelter-seeking behavioral responses from the fish when disturbed. It is recommended to test enrichment strategies in real scenarios for a relevant part of the fish's life cycle to fully understand their potential for improving welfare in aquaculture.
Article
Psychology, Multidisciplinary
Grace De Hoyos, Darlenne Ramos-Sostre, Annelyn Torres-Reveron, Barbara Barros-Cartagena, Veronica Lopez-Rodriguez, Cristina Nieves-Vazquez, Fanny Santiago-Saavedra, Caroline B. Appleyard, Eida M. Castro, Idhaliz Flores
Summary: This study investigated the efficacy of an environmental enrichment (EE) intervention on patients with endometriosis through a randomized clinical trial. The results showed significant improvements in anxiety and depressive symptoms, quality of life, and perceived stress in the patients who received the EE intervention. This supports the use of enriched environments as an adjunct to standard care for endometriosis pain.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
L. Jacobs, R. A. Blatchford, I. C. De Jong, M. A. Erasmus, M. Levengood, R. C. Newberry, P. Regmi, A. B. Riber, S. L. Weimer
Summary: This paper discusses the impact of environmental enrichment on poultry welfare through four themes and emphasizes the importance of considering enrichment strategies from the birds' perspective. It also suggests methods for improving play behavior and activity levels. Although previous research has shown that environmental complexity can increase poultry activity levels and behavior, more studies are needed on birds' resilience, the effects in commercial conditions, and slower-growing strains.
Article
Behavioral Sciences
Jhon Buenhombre, Erika Alexandra Daza-Cardona, Pessi Sousa, Amauri Gouveia Jr, Maria Nelly Cajiao-Pachon
Summary: Environmental enrichment in zebrafish has positive effects on reducing anxiety-related behaviors, improving learning, and increasing health and biological fitness. However, certain types of enrichment or conditions may have opposite effects. This study investigates the influence of structural environmental enrichment and the way it is offered on cognitive judgment bias and anxiety-like behaviors in adult zebrafish.
Article
Agriculture, Dairy & Animal Science
Gwang-Hoon Lee, Woori Jo, Tae-Ku Kang, Taeho Oh, KilSoo Kim
Summary: This study aimed to find a suitable environment to reduce the stress of captive dogs and concluded that social housing and environmental enrichment can effectively reduce stress levels in dogs. It provides valuable insights for improving the welfare of kenneled dogs in captive animal organizations.
Review
Fisheries
Zonghang Zhang, Lijia Gao, Xiumei Zhang
Summary: Through meta-analyses, this study found that aquatic animals from enriched environments showed significantly better welfare compared to those from barren environments. Specific welfare traits, animal taxa, animal stages, enrichment types, and colors had strong positive effects on aquatic animal welfare.
REVIEWS IN AQUACULTURE
(2022)
Article
Agriculture, Dairy & Animal Science
Gokulan Nagabaskaran, Morgan Skinner, Noam Miller
Summary: With the increasing popularity of snakes in the pet trade, it is important to investigate their preferences for environmental enrichment in order to ensure their welfare in captivity. This study found that western hognose snakes significantly prefer environmental enrichment compared to minimalistic conditions. These findings highlight the importance of considering the welfare needs of captive snake species and provide a basis for further research into enrichment opportunities.
Article
Agriculture, Dairy & Animal Science
Cesar Marcial Escobedo-Bonilla, Noelia Maria Quiros-Rojas, Esteban Rudin-Salazar
Summary: Sea turtles are vital members of marine ecosystems, and conservation efforts are crucial to protect them. Environmental enrichment is a valuable tool to improve the welfare of sea turtles in captivity and rehabilitation, increasing their chances of survival and integration back into the wild after release. Adopting environmental enrichment practices in rescue and rehabilitation facilities globally can help enhance individual survival and conservation efforts for endangered species.
Article
Agriculture, Dairy & Animal Science
Emily J. Dickson, Dana L. M. Campbell, Caroline Lee, Jim M. Lea, Paul G. McDonald, Jessica E. Monk
Summary: The study focused on how environmental enrichment, such as a cattle brush, hanging rope, tree stump, and woodchip pile, can enhance the welfare of beef cattle kept in barren pasture environments. While cattle showed a preference for the brush, stump, and woodchip, their overall use of enrichments decreased over time. The enrichments allowed for natural behaviors and potentially contributed to improved welfare.
Article
Agriculture, Dairy & Animal Science
Tatjana Hoehfurtner, Anna Wilkinson, Gokulan Nagabaskaran, Oliver H. P. Burman
Summary: Research demonstrates that providing environmental enrichment for captive corn snakes can improve their behavior and welfare. While the effects on anxiety tests are minimal, snakes exhibit a strong preference for the enriched enclosure when given a choice.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2021)
Editorial Material
Agriculture, Dairy & Animal Science
Temple Grandin
Summary: In many countries, pigs and broiler chickens are raised in intensive systems without proper environmental enrichments. Large retail and restaurant buyers have played a significant role in improving animal welfare by enforcing basic welfare standards on farms and slaughter plants. This paper focuses on practical environmental enrichments for pigs and broiler chickens, highlighting the importance of engaging enrichment objects that meet the animals' preferences and needs.
Article
Oncology
Michelle C. Bufalo, Maira E. Almeida, Isabella Araujo Franca, Vanessa O. Zambelli, Morena Brazil Martins Sant'anna, Louise F. Kimura, Aline Carolina Giardini, Yara Cury, Sandra Coccuzzo Sampaio
EXPERIMENTAL CELL RESEARCH
(2019)
Article
Neurosciences
Barbara Guimaraes de Freitas, Leandro Marcio Pereira, Flavia Vianna Santa-Cecilia, Natalia Gabriele Hosch, Gisele Picolo, Yara Cury, Vanessa O. Zambelli
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Food Science & Technology
Morena Brazil Sant'Anna, Flavia Souza Ribeiro Lopes, Louise Faggionato Kimura, Aline Carolina Giardini, Osvaldo Augusto Sant'Anna, Gisele Picolo
Article
Neurosciences
Louise Faggionato Kimura, Morena Brazil Sant'Anna, Vanessa Olzon Zambelli, Aline Carolina Giardini, Simone Goncalves Silva Jared, Marta Maria Antoniazzi, Vania Gomes de Moura Mattaraia, Rosana Lima Pagano, Gisele Picolo
EXPERIMENTAL NEUROLOGY
(2020)
Review
Pharmacology & Pharmacy
Louise F. Kimura, Leonardo S. Novaes, Gisele Picolo, Carolina D. Munhoz, Chi W. Cheung, Rosana Camarini
Summary: This review discusses the role of inflammation as a major biological substrate and etiological factor of chronic pain and depression/anxiety, as well as the potential beneficial actions of environmental enrichment in chronic pain and comorbid depression/anxiety through its effects on microglia. Additionally, alternative interventions like environmental enrichment may improve treatment compliance and patient outcomes according to clinical guidelines.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Hematology
Louise F. Kimura, Morena B. Sant'Anna, Sonia A. Andrade, Matteo C. Ebram, Cristiane F. G. Lima, Rosa M. G. Celano, Ruy F. M. Viegas, Gisele Picolo
Summary: The study suggests that dyslipidemia and hematological changes observed in COVID-19 patients may be caused by the infection itself, even in patients without comorbidities like T2DM and obesity. Controlling parameters such as HDL levels, NLR, and hemoglobin concentration could be an effective strategy to prevent COVID-19 complications and death.
BLOOD CELLS MOLECULES AND DISEASES
(2021)
Article
Food Science & Technology
Aline C. Giardini, Bianca G. Evangelista, Morena B. Sant'Anna, Barbara B. Martins, Carmen L. P. Lancellotti, Adriano P. Ciena, Marucia Chacur, Rosana L. Pagano, Orlando G. Ribeiro, Vanessa O. Zambelli, Gisele Picolo
Summary: The study indicates that Crotalphine (CRO) may have beneficial effects on multiple sclerosis (MS) by inhibiting neuroinflammation and improving symptoms to control disease progression.
Article
Cell Biology
Michelle Cristiane Bufalo, Maira Estanislau Soares de Almeida, Jose Ricardo Jensen, Carlos DeOcesano-Pereira, Flavio Lichtenstein, Gisele Picolo, Ana Marisa Chudzinski-Tavassi, Sandra Coccuzzo Sampaio, Yara Cury, Vanessa Olzon Zambelli
Summary: This study established a functional model using collagen-derived advanced glycation end-products as a stimulus, and human sensory-like neurons for screening analgesic compounds. The results suggest that this model can be used for screening candidates for the management of painful conditions.
Article
Biochemistry & Molecular Biology
Flavia S. R. Lopes, Aline C. Giardini, Morena B. Sant'Anna, Louise F. Kimura, Michelle C. Bufalo, Hugo Vigerelli, Vanessa O. Zambelli, Gisele Picolo
Summary: Crotalphine exhibits potent and long-lasting analgesic effects in acute and chronic pain models, mediated by activation of opioid and cannabinoid analgesic systems and inhibition of central neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Rafaela Indalecio Moreno, Vanessa O. Zambelli, Gisele Picolo, Yara Cury, Andre C. Morandini, Antonio Carlos Marques, Juliana Mozer Sciani
Summary: Neuroinflammation, a condition associated with dementia such as Alzheimer's disease, can be caused by an inflammatory response to amyloid peptides. This study identified new caspase-1 and cathepsin B inhibitors from Brazilian marine invertebrates. The extract of the box jellyfish Chiropsalmus quadrumanus was found to inhibit caspase-1, and trigonelline was identified as the active molecule. Additionally, betaine from Exaiptasia diaphana was shown to inhibit cathepsin B. These new prototypes may provide potential targets for enzyme inhibition and control of neuroinflammation.
Article
Cell Biology
Megan M. McCollum, Megan Larmore, Shingo Ishihara, Leo C. T. Ng, Louise F. Kimura, Eduardo Guadarrama, My C. Ta, Thuy N. Vien, Grant B. Frost, Karl A. Scheidt, Rachel E. Miller, Paul G. DeCaen
Summary: The tamoxifen analog N-desmethyltamoxifen (ND-Tam) and its derivatives can bind to two conserved intracellular receptor sites in NaV1.7, blocking ion entry and inhibiting the sodium current. This results in a potent frequency and voltage-dependent block of hyperexcitable nociceptive neuron action potentials implicated in OA pain. In a mouse OA pain model, ND-Tam shows long-lasting efficacy, suggesting its potential as a NaV antagonist for OA pain management.
Article
Immunology
Morena Brazil Sant'Anna, Aline C. Giardini, Marcio A. C. Ribeiro, Flavia S. R. Lopes, Nathalia B. Teixeira, Louise F. Kimura, Michelle C. Bufalo, Orlando G. Ribeiro, Andrea Borrego, Wafa H. K. Cabrera, Julio C. B. Ferreira, Vanessa O. Zambelli, Osvaldo A. Sant'Anna, Gisele Picolo
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)