Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab
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Title
Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab
Authors
Keywords
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Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 39, Issue 5, Pages 956-964
Publisher
Ovid Technologies (Wolters Kluwer Health)
Online
2019-04-18
DOI
10.1161/atvbaha.118.312314
References
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Related references
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- Current and future antiplatelet therapies: emphasis on preserving haemostasis
- (2018) James D. McFadyen et al. Nature Reviews Cardiology
- Immobilized fibrinogen activates human platelets through glycoprotein VI
- (2018) Pierre H Mangin et al. HAEMATOLOGICA
- Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks
- (2017) Kristell Lebozec et al. mAbs
- Global Burden of Thrombosis: Table.
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- Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation
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- (2016) Sam Song et al. Journal of Immunology Research
- Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation
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- Early Deterioration After Thrombolysis Plus Aspirin in Acute Stroke
- (2014) Sanne M. Zinkstok et al. STROKE
- An adenine insertion in exon 6 of humanGP6generates a truncated protein associated with a bleeding disorder in four Chilean families
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- (2013) Henri H. Versteeg et al. PHYSIOLOGICAL REVIEWS
- The future of glycoprotein VI as an antithrombotic target
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- (2010) David Stegner et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations
- (2009) B. Dumont et al. BLOOD
- Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression
- (2008) P. OHLMANN et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
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