Epigenetic Mechanisms in Monocytes/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diabetes Mellitus-Induced Long Noncoding RNADnm3osRegulates Macrophage Functions and Inflammation via Nuclear Mechanisms

(2018) Sadhan Das et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads

(2018) Frank M. Davis et al.   Current Diabetes Reports

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

(2018) Tamer Sallam et al.   NATURE MEDICINE

Macrophage polarization and meta-inflammation

(2018) Chuan Li et al.   Translational Research

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages

(2018) Jinglian Yan et al.   Nature Communications

SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells

(2018) Bradley J. Toghill et al.   Clinical Epigenetics

The salient role of microRNAs in atherogenesis

(2018) Callum J. Donaldson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Long Noncoding RNAs in Atherosclerosis

(2018) Zhengyi Zhang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

European Society of Cardiology: Cardiovascular Disease Statistics 2017

(2017) et al.   EUROPEAN HEART JOURNAL

Epigenetic mechanisms of macrophage activation in type 2 diabetes

(2017) Mohamed Ahmed et al.   IMMUNOBIOLOGY

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

(2017) Christopher B. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of innate and adaptive immunity in obesity-associated metabolic disease

(2017) Tracey McLaughlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing

(2017) Anna E. Boniakowski et al.   JOURNAL OF IMMUNOLOGY

Monocytes and macrophages in abdominal aortic aneurysm

(2017) Juliette Raffort et al.   Nature Reviews Cardiology

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dnmt3arestrains mast cell inflammatory responses

(2017) Cristina Leoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells

(2017) Annette E Neele et al.   Epigenomics

Mechanisms of MicroRNAs in Atherosclerosis

(2016) Andreas Schober et al.   Annual Review of Pathology-Mechanisms of Disease

Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques

(2016) Anna Greißel et al.   CARDIOVASCULAR PATHOLOGY

MicroRNA Regulation of Atherosclerosis

(2016) Mark W. Feinberg et al.   CIRCULATION RESEARCH

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors

(2016) María Galán et al.   Disease Models & Mechanisms

Long Noncoding RNA HOXC-AS1 Suppresses Ox-LDL-Induced Cholesterol Accumulation Through Promoting HOXC6 Expression in THP-1 Macrophages

(2016) Chuan Huang et al.   DNA AND CELL BIOLOGY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth

(2016) Šárka Lhoták et al.   Journal of the American Heart Association

Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis

(2016) Yun-Cheng Lv et al.   PLoS One

Apolipoprotein E Enhances MicroRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor- B-Driven Inflammation and Atherosclerosis

(2015) K. Li et al.   CIRCULATION RESEARCH

Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic MiceNovelty and Significance

(2015) Mohan Babu et al.   CIRCULATION RESEARCH

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis

(2015) Annette E. Neele et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histone deacetylase 5 regulates the inflammatory response of macrophages

(2015) Lukas Poralla et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

Alcohol-Induced miR-27a Regulates Differentiation and M2 Macrophage Polarization of Normal Human Monocytes

(2015) Banishree Saha et al.   JOURNAL OF IMMUNOLOGY

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

Epigenetic mechanisms underlying type 2 diabetes mellitus

(2015) Mark A. Hanson et al.   Nature Reviews Endocrinology

The Role of Different Monocyte Subsets in the Pathogenesis of Atherosclerosis and Acute Coronary Syndromes

(2015) E. Idzkowska et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The role of long non-coding RNAs in genome formatting and expression

(2015) Pierre-Olivier Angrand et al.   Frontiers in Genetics

Histone Deacetylase 9 Represses Cholesterol Efflux and Alternatively Activated Macrophages in Atherosclerosis Development

(2014) Qiang Cao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage polarization

(2014) Jan Van den Bossche et al.   CURRENT OPINION IN LIPIDOLOGY

Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes

(2014) Katherine A. Gallagher et al.   DIABETES

Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA

(2014) M. A. Reddy et al.   DIABETES

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

(2014) M. A. Hoeksema et al.   EMBO Molecular Medicine

Anti-inflammatory therapies for cardiovascular disease

(2014) P. M. Ridker et al.   EUROPEAN HEART JOURNAL

Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies

(2014) Frank M Davis et al.   HEART

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Epigenomics of macrophages

(2014) David Gosselin et al.   IMMUNOLOGICAL REVIEWS

The effects of Liuwei Dihuang on canonical Wnt/β-catenin signaling pathway in osteoporosis

(2014) Bingjiang Xia et al.   JOURNAL OF ETHNOPHARMACOLOGY

lncRNAs: Insights into their function and mechanics in underlying disorders

(2014) Xiaolei Li et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1- and microRNA-155 –Dependent Pathway During Atherosclerosis

(2013) Yuanyuan Wei et al.   CIRCULATION

Aneurysm Global Epidemiology Study

(2013) David Sidloff et al.   CIRCULATION

Interplay of chromatin modifications and non-coding RNAs in the heart

(2013) Prabhu Mathiyalagan et al.   Epigenetics

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Epigenetically regulated microRNAs in Alzheimer's disease

(2013) Daniel L. Van den Hove et al.   NEUROBIOLOGY OF AGING

Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

(2013) Nicolai A. Kittan et al.   PLoS One

Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease

(2013) Martin Dichgans et al.   STROKE

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Environmental exposures, epigenetics and cardiovascular disease

(2012) Andrea Baccarelli et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

(2012) Jan Van den Bossche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts

(2012) Marco Magistri et al.   TRENDS IN GENETICS

Epigenetic regulation of macrophage polarization and function

(2012) Lionel B. Ivashkiv   TRENDS IN IMMUNOLOGY

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

(2012) Xing Cai et al.   Journal of Molecular Cell Biology

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Diabetes Complications: The MicroRNA Perspective

(2011) P. Kantharidis et al.   DIABETES

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

MicroRNAs and epigenetics

(2011) Fumiaki Sato et al.   FEBS Journal

MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4

(2011) Ke Yang et al.   FEBS LETTERS

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

MicroRNA-125b Potentiates Macrophage Activation

(2011) Aadel A. Chaudhuri et al.   JOURNAL OF IMMUNOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Maintaining Cell Identity through Global Control of Genomic Organization

(2010) Gioacchino Natoli   IMMUNITY

Differential Requirement of Histone Acetylase and Deacetylase Activities for IRF5-Mediated Proinflammatory Cytokine Expression

(2010) D. Feng et al.   JOURNAL OF IMMUNOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase C 

(2009) P. Gandellini et al.   CANCER RESEARCH

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

(2009) J. M. Friedman et al.   CANCER RESEARCH

Role of macrophage tissue infiltration in obesity and insulin resistance

(2009) V. Bourlier et al.   DIABETES & METABOLISM

Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem Cells

(2009) Aster H. Juan et al.   MOLECULAR CELL

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-κB-dependent Inflammatory Genes

(2008) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-148 targets human DNMT3b protein coding region

(2008) A. M. Duursma et al.   RNA

Mechanisms of macrophage activation in obesity-induced insulin resistance

(2008) Justin I Odegaard et al.   Nature clinical practice. Endocrinology & metabolism