Review
Biochemistry & Molecular Biology
Irina Bure, Marina Nemtsova, Ekaterina B. Kuznetsova
Summary: In recent years, scientists have increasingly suggested and confirmed that epigenetic regulators are closely linked and form a comprehensive network of regulatory pathways and feedback loops. This is particularly important for a better understanding of the development and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Alexandru A. Sabo, Maria Dudau, George L. Constantin, Tudor C. Pop, Christoph-M. Geilfus, Alessio Naccarati, Mihnea P. Dragomir
Summary: Cancer is a devastating disease and a major public health burden, with chemotherapy being a key treatment and natural compounds playing an important role in new chemotherapies. Natural compounds may impact cancer by modulating the expression and function of non-coding RNAs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pathology
Ketao Li, Liping Ma, Zhiwei Lu, Laixing Yan, Wan Chen, Bing Wang, Huiju Xu, Zatollah Asemi
Summary: Heart failure is a cardiovascular condition where the heart fails to pump blood and oxygen adequately. Apoptosis, a controlled cell death process, affects various cardiovascular illnesses, including myocardial infarction and reperfusion injury. Non-coding RNAs (ncRNAs) have been found to influence protein stability, transcription factor control, and apoptosis in heart failure. Exosomes play a significant role in disease regulation and organ communication, but it is unclear if they modulate the interaction between cardiomyocytes and tumor cells in ischemic heart failure. This article highlights the ncRNAs associated with apoptosis in heart failure and emphasizes the importance of exosomal ncRNAs in the disease.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pharmacology & Pharmacy
Wenhao Zhu, Renshan Zhao, Xiaomin Guan, Xu Wang
Summary: This review comprehensively analyzes the impact of m(6)A methylation on Prostate cancer, bladder cancer, and renal cell cancer, as well as the relationship between the expression of relevant regulatory factors and their development and occurrence, providing new insights and approaches for the early clinical diagnosis and targeted therapy of urologic malignancies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Quanah J. Hudson, Katharina Proestling, Alexandra Perricos, Lorenz Kuessel, Heinrich Husslein, Rene Wenzl, Iveta Yotova
Summary: Studies have shown that lncRNAs play an important role in the pathogenesis of endometriosis, with SNPs and genome-wide transcriptomic studies confirming this.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Review
Cardiac & Cardiovascular Systems
Nazha Hamdani, Sarah Costantino, Andreas Muegge, Djamel Lebeche, Carsten Tschoepe, Thomas Thum, Francesco Paneni
Summary: HFpEF, described as the 'single largest unmet need in cardiovascular medicine', is currently untreatable and associated with poor prognosis and unsustainable healthcare costs. Epigenetic modifications play a significant role in the pathogenesis of HFpEF, offering potential for personalized management of heart failure.
EUROPEAN HEART JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Jingyi Han, Qinqin Liu, Yao Zhou, Dong Li, Ran Wang
Summary: This study revealed significant differences in the levels and patterns of m7G methylation between drug-resistant AML cells and AML cells. Furthermore, the study predicted the cellular functions potentially influenced by m7G in drug-resistant AML cells, providing evidence implicating m7G-mediated lncRNA epigenetic regulation in the progression of drug resistance in AML.
Review
Cell Biology
Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: Non-coding RNAs play a crucial role in regulating angiogenesis in glioblastoma, affecting gene transcription and the expression of angiogenesis-inducing molecules through various mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Sara Fadaei, Fatemeh Zarepour, Mehrnoosh Parvaresh, Alireza Motamedzadeh, Seyed Saeed Tamehri Zadeh, Amirhossein Sheida, Mohammad Shabani, Michael R. Hamblin, Mehdi Rezaee, Maryam Zarei, Hamed Mirzaei
Summary: Myocardial infarction (MI) is a leading cause of global deaths. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), have been found to regulate pathological processes in MI, and exosomal ncRNAs have been shown to play important roles in cell communication and disease development. Therefore, understanding the role of ncRNAs and exosomal ncRNAs in MI is of great significance for diagnosis and prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Gu Yang, Yanjiao Wu, Rongxue Wan, Hongxun Sang, Huan Liu, Wenhua Huang
Summary: Osteosarcoma is an aggressive bone tumor with early metastasis potential and poor response to chemoradiotherapy. Non-coding RNAs have been shown to play a significant role in the initiation and progression of this tumor.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cinzia Aurilia, Simone Donati, Gaia Palmini, Francesca Miglietta, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Tumors of the parathyroid glands are common endocrine diseases characterized by parathyroid hormone hypersecretion, with a wide range of clinical presentations and typically treated through surgical removal. Recent studies have suggested that alterations to the epigenetic mechanisms could play a pivotal role in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xinyi Cai, Hui Wang, Yingli Han, He Huang, Pengxu Qian
Summary: This study summarizes the latest information on small non-coding RNAs and RNA modifications in normal and malignant hematopoiesis, providing new insights into the future application of hematopoietic stem cells in the treatment of blood diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Heidi Schwarzenbach, Peter B. Gahan
Summary: Although lncRNAs are precursors of miRNAs, they also act as ceRNAs and their interaction with miRNAs may modulate miRNA action. To understand their contribution to tumor resistance, both the function of miRNAs and the impact of lncRNAs on miRNAs need to be considered. This study focuses on the interplay between lncRNAs and miRNAs in the post-transcriptional regulatory network and their impact on breast cancer treatment drugs. Considering this interplay may improve the search for new drugs to overcome chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Elisabetta Lauretti, Konrad Dabrowski, Domenico Pratico
Summary: Non-protein-coding RNAs have been found to play significant roles in neurodegenerative disorders such as Alzheimer's disease, affecting gene expression, amyloid-beta production, and other key mechanisms underlying disease pathology.
AGEING RESEARCH REVIEWS
(2021)
Article
Immunology
Vera P. Mourits, Rob J. W. Arts, Boris Novakovic, Vasiliki Matzaraki, L. Charlotte J. de Bree, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Jelmer H. van Puffelen, Laszlo Groh, Charlotte D. C. C. van der Heijden, Sam T. Keating, Mihai G. Netea, Marije Oosting, Leo A. B. Joosten
Article
Cardiac & Cardiovascular Systems
David M. Kaye, Waled A. Shihata, Hamdi A. Jama, Kirill Tsyganov, Mark Ziemann, Helen Kiriazis, Duncan Horlock, Amrita Vijay, Beverly Giam, Antony Vinh, Chad Johnson, April Fiedler, Daniel Donner, Matthew Snelson, Melinda T. Coughlan, Sarah Phillips, Xiao-Jun Du, Assam El-Osta, Grant Drummond, Gavin W. Lambert, Tim D. Spector, Ana M. Valdes, Charles R. Mackay, Francine Z. Marques
Article
Cardiac & Cardiovascular Systems
Charlotte D. C. C. van der Heijden, Laszlo Groh, Samuel T. Keating, Charlotte Kaffa, Marlies P. Noz, Simone Kersten, Antonius E. van Herwaarden, Alexander Hoischen, Leo A. B. Joosten, Henri J. L. M. Timmers, Mihai G. Netea, Niels P. Riksen
CIRCULATION RESEARCH
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Harikrishnan Kaipananickal, Abdul Waheed Khan, Jun Okabe, Susan J. Corcoran, Murray D. Esler, Assam El-Osta
CIRCULATION RESEARCH
(2020)
Article
Genetics & Heredity
Samuel T. Keating, Laszlo Groh, Kathrin Thiem, Siroon Bekkering, Yang Li, Vasiliki Matzaraki, Charlotte D. C. C. van der Heijden, Jelmer H. van Puffelen, Ekta Lachmandas, Trees Jansen, Marije Oosting, L. Charlotte J. de Bree, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Vera P. Mourits, Janna van Diepen, Rinke Strienstra, Boris Novakovic, Hendrik G. Stunnenberg, Reinout van Crevel, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Cell Biology
Samuel T. Keating, Laszlo Groh, Charlotte D. C. C. van der Heijden, Hanah Rodriguez, Jessica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Vera P. Mourits, Jorge Dominguez-Andres, Marije Oosting, Elianne P. Bulthuis, Werner J. H. Koopman, Musa Mhlanga, Assam El-Osta, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Article
Cardiac & Cardiovascular Systems
Michelle C. Flynn, Michael J. Kraakman, Christos Tikellis, Man K. S. Lee, Nordin M. J. Hanssen, Helene L. Kammoun, Raelene J. Pickering, Dragana Dragoljevic, Annas Al-Sharea, Tessa J. Barrett, Fiona Hortle, Frances L. Byrne, Ellen Olzomer, Domenica A. McCarthy, Casper G. Schalkwijk, Josephine M. Forbes, Kyle Hoehn, Liza Makowski, Graeme I. Lancaster, Assam El-Osta, Edward A. Fisher, Ira J. Goldberg, Mark E. Cooper, Prabhakara R. Nagareddy, Merlin C. Thomas, Andrew J. Murphy
CIRCULATION RESEARCH
(2020)
Correction
Genetics & Heredity
Samuel T. Keating, Laszlo Groh, Kathrin Thiem, Siroon Bekkering, Yang Li, Vasiliki Matzaraki, Charlotte D. C. C. van der Heijden, Jelmer H. van Puffelen, Ekta Lachmandas, Trees Jansen, Marije Oosting, L. Charlotte J. de Bree, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Vera P. Mourits, Janna van Diepen, Rinke Stienstra, Boris Novakovic, Hendrik G. Stunnenberg, Reinout van Crevel, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Urology & Nephrology
Jelmer H. van Puffelen, Samuel T. Keating, Egbert Oosterwijk, Antoine G. van der Heijden, Mihai G. Netea, Leo A. B. Joosten, Sita H. Vermeulen
NATURE REVIEWS UROLOGY
(2020)
Article
Immunology
Kathrin Thiem, Samuel T. Keating, Mihai G. Netea, Niels P. Riksen, Cees J. Tack, Janna van Diepen, Rinke Stienstra
Summary: Research suggests that high blood sugar levels may induce trained immunity, leading to inflammation and increasing the risk of diabetes-related complications in patients.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Z. Shi, J. Tuomilehto, N. Kronfeld-Schor, G. K. Alberti, N. Stern, A. El-Osta, C. Bilu, H. Einat, P. Zimmet
Summary: The study revealed that the circadian syndrome is a stronger and better predictor for cardiovascular disease in Chinese adults compared to the metabolic syndrome.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Sih Min Tan, Runa S. J. Lindblom, Mark Ziemann, Adrienne Laskowski, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Assam El-Osta, Carlos D. Baeza-Garza, Stuart T. Caldwell, Richard C. Hartley, Thomas Krieg, Mark E. Cooper, Michael P. Murphy, Melinda T. Coughlan
Summary: The study investigated the use of MitoGamide to target methylglyoxal within the mitochondria for treating diabetic kidney disease (DKD), but found that it did not substantially improve the renal phenotype in an experimental model of diabetes. The findings suggest that targeting methylglyoxal within the mitochondria using MitoGamide may not be a valid therapeutic approach for DKD, and that other mitochondrial targets or processes upstream should be the focus of therapy.
Review
Cardiac & Cardiovascular Systems
Samuel T. Keating, Assam El-Osta
Summary: The influence of cellular metabolism on epigenetic pathways is complex and often misunderstood. Recent studies have revealed connections between metabolism, cancer, and immunity, highlighting the importance of understanding these interactions. Metabolic shifts can affect gene expression and nuclear processes, while the immune system and cardiovascular disease are also influenced by metabolic-epigenetic connections.
CARDIOVASCULAR RESEARCH
(2023)
Article
Nutrition & Dietetics
Zumin Shi, Jaakko Tuomilehto, Noga Kronfeld-Schor, George Alberti, Naftali Stern, Assam El-Osta, Zhonglin Chai, Carmel Bilu, Haim Einat, Paul Zimmet
Summary: This study aimed to compare the predictive value of Circadian Syndrome (CircS) and Metabolic Syndrome (MetS) for cardiovascular disease (CVD). The results showed that CircS had a stronger predictive power for prevalent CVD than MetS in US adults.
