Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition.

(2019) Maxim S. Svetlov et al.   RNA

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

(2018) Jinzhong Lin et al.   Annual Review of Biochemistry

Occurrence and stability of lone pair–π stacking interactions between ribose and nucleobases in functional RNAs

(2017) Mohit Chawla et al.   NUCLEIC ACIDS RESEARCH

The extended loops of ribosomal proteins uL4 and uL22 ofEscherichia colicontribute to ribosome assembly and protein translation

(2016) Marlon G. Lawrence et al.   NUCLEIC ACIDS RESEARCH

Resistance to Macrolide Antibiotics in Public Health Pathogens

(2016) Corey Fyfe et al.   Cold Spring Harbor Perspectives in Medicine

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome

(2014) Arren Z. Washington et al.   ACS Chemical Biology

Macrolide antibiotics allosterically predispose the ribosome for translation arrest

(2014) Shanmugapriya Sothiselvam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis

(2012) Y. S. Polikanov et al.   SCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis

(2010) B. Llano-Sotelo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics

(2010) Lu Ying et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding

(2010) Janine H. Peterson et al.   MOLECULAR MICROBIOLOGY

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the structures of several antibiotics bound to the bacterial ribosome

(2010) D. Bulkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency

(2009) Martin Lovmar et al.   EMBO JOURNAL