Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models

Seizure-induced reduction in glucose utilization promotes brain hypometabolism during epileptogenesis

(2018) Anton Malkov et al.   NEUROBIOLOGY OF DISEASE

Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation

(2018) Michael Chang et al.   NEUROBIOLOGY OF DISEASE

Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization

(2018) Oscar C. González et al.   NEUROBIOLOGY OF DISEASE

Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy

(2018) Selvin Z. Reyes-Garcia et al.   Scientific Reports

Kainate Receptors: Role in Epilepsy

(2018) Rafael Falcón-Moya1 et al.   Frontiers in Molecular Neuroscience

Low-Voltage Fast Seizures in Humans Begin With Increased Interneuron Firing

(2018) Bahareh Elahian et al.   ANNALS OF NEUROLOGY

Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders

(2017) Premysl Jiruska et al.   EPILEPSIA

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

(2017) Silvia Sorce et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species

(2017) Stjepana Kovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic Dysfunction and Oxidative Stress in Epilepsy

(2017) Jennifer Pearson-Smith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons

(2016) Fadi Assaf et al.   JOURNAL OF NEUROPHYSIOLOGY

A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity

(2016) Gabriele Losi et al.   JOURNAL OF NEUROSCIENCE METHODS

Interneuron activity leads to initiation of low-voltage fast-onset seizures

(2015) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy

(2015) A. Pecorelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

GABAergic inhibition shapes interictal dynamics in awake epileptic mice

(2015) Sarah Feldt Muldoon et al.   BRAIN

Intracranially recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy

(2015) Kyoko Kanazawa et al.   CLINICAL NEUROPHYSIOLOGY

Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

(2015) Latefa Yekhlef et al.   JOURNAL OF NEUROPHYSIOLOGY

KCC2 function modulates in vitro ictogenesis

(2015) Shabnam Hamidi et al.   NEUROBIOLOGY OF DISEASE

Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy

(2015) Sreekanth Puttachary et al.   Biomed Research International

Biomarkers of epileptogenic zone defined by quantified stereo-EEG analysis

(2014) Vadym Gnatkovsky et al.   EPILEPSIA

Reactive Oxygen Species Initiate a Metabolic Collapse in Hippocampal Slices: Potential Trigger of Cortical Spreading Depression

(2014) Anton Malkov et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Research advances in basic mechanisms of seizures and antiepileptic drug action

(2014) Władysław Lasoń et al.   Pharmacological Reports

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology

(2013) Piero Perucca et al.   BRAIN

Issues related to development of new antiseizure treatments

(2013) Karen S. Wilcox et al.   EPILEPSIA

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Evidence-based review on the natural history of the epilepsies

(2012) Dieter Schmidt et al.   CURRENT OPINION IN NEUROLOGY

Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats

(2012) Jun Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology

(2012) S Schiavone et al.   Translational Psychiatry

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity

(2011) Massimo Avoli et al.   PROGRESS IN NEUROBIOLOGY

Ictal Localization by Invasive Recording of Infraslow Activity with DC-Coupled Amplifiers

(2009) Wonsuk Kim et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY