Cell‐type‐specific role of lamin‐B1 in thymus development and its inflammation‐driven reduction in thymus aging

A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation

(2018) Eric M. Kernfeld et al.   IMMUNITY

Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery

(2018) Xiaobin Zheng et al.   MOLECULAR CELL

Single-cell RNA-sequencing resolves self-antigen expression during mTEC development

(2018) Ricardo J. Miragaia et al.   Scientific Reports

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

Lamin in inflammation and aging

(2016) Joseph R Tran et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

(2016) Svetlana Ulyanchenko et al.   Cell Reports

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

(2016) Kathy E. O’Neill et al.   PLoS One

Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus

(2015) Immanuel Rode et al.   JOURNAL OF IMMUNOLOGY

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

(2014) Haiyang Chen et al.   CELL

Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins

(2014) Yuxuan Guo et al.   MOLECULAR BIOLOGY OF THE CELL

Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution

(2014) Sanghee Ki et al.   Cell Reports

Generation and characterization of a conditional deletion allele for Lmna in mice

(2013) Youngjo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

(2013) Oliver Dreesen et al.   JOURNAL OF CELL BIOLOGY

Transcriptome sequencing of neonatal thymic epithelial cells

(2013) Charles St-Pierre et al.   Scientific Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

It’s not all equal: a multiphasic theory of thymic involution

(2011) Danielle Aw et al.   BIOGERONTOLOGY

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

(2011) E. C. Zook et al.   BLOOD

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

(2011) Catherine Coffinier et al.   MOLECULAR BIOLOGY OF THE CELL

Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses

(2011) Matthew J. Billard et al.   PLoS One

Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

(2011) Y. Kim et al.   SCIENCE

Postnatal Tissue-specific Disruption of Transcription Factor FoxN1 Triggers Acute Thymic Atrophy

(2009) Lili Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

Architectural changes in the thymus of aging mice

(2008) Danielle Aw et al.   AGING CELL

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

(2008) L. Chen et al.   BLOOD

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Inflammatory signaling and cellular senescence

(2008) Jian-Lin Ren et al.   CELLULAR SIGNALLING

Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells

(2008) M. G. L. Depreter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA