Review
Environmental Sciences
Gyeyoon Yim, Yuting Wang, Caitlin G. Howe, Megan E. Romano
Summary: This scoping review summarizes the literature on the cardiotoxicity of exposure to metal mixtures and identifies the trends and focus areas in the research. The majority of the studies were conducted in the United States and China, with an increase in publications in recent years. The commonly investigated metals included cadmium, lead, arsenic, and cobalt, with a focus on their impact on blood pressure, preeclampsia, dyslipidemia, and cardiovascular disease outcomes.
Article
Peripheral Vascular Disease
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: This study analyzed the association between home and ambulatory blood pressure monitoring and cardiovascular risk in hypertensive outpatients, and found that both home blood pressure and ambulatory blood pressure were independently associated with cardiovascular risk. Home blood pressure had a modest superiority to predict cardiovascular prognosis compared to ambulatory blood pressure.
Review
Medicine, General & Internal
Fabio Angeli, Gianpaolo Reboldi, Francesco Giuseppe Solano, Antonietta Prosciutto, Antonella Paolini, Martina Zappa, Claudia Bartolini, Andrea Santucci, Stefano Coiro, Paolo Verdecchia
Summary: Several outcome-based prospective investigations have shown the prognostic value of 24-hour ambulatory blood pressure monitoring in cardiovascular risk stratification. Average 24-hour, daytime, and nighttime blood pressures are essential components that improve risk assessment beyond traditional factors. However, the interpretation and clinical use of ambulatory blood pressure monitoring need standardization, and implementing its results in individual patient management remains challenging.
Review
Peripheral Vascular Disease
Gonzalo Saco-Ledo, Pedro L. Valenzuela, Miguel Ramirez-Jimenez, Javier S. Morales, Adrian Castillo-Garcia, James A. Blumenthal, Luis M. Ruilope, Alejandro Lucia
Summary: Studies have shown that a single bout of acute aerobic exercise can effectively reduce 24-hour, daytime, and nighttime blood pressure in hypertensive patients, with similar effects in both medicated and non-medicated individuals. Aerobic exercise has the most significant impact on blood pressure, while resistance or combined (aerobic and resistance) exercise has no significant effects on blood pressure.
Article
Nutrition & Dietetics
Yejin Kim, Hye-Ji An, Young-Gyun Seo
Summary: This study evaluated the relationship between breakfast and sleep timing on cardiovascular disease risk factors. The study found that the combination of skipping breakfast and late sleep timing was associated with a higher prevalence of MetS, particularly in men. Additionally, there were differences in the relationship between breakfast and sleep timing on CVD risk factors by sex and age group.
Review
Nutrition & Dietetics
David A. Jaques, Gregoire Wuerzner, Belen Ponte
Summary: Excessive salt intake can lead to high blood pressure and various adverse consequences. Reducing salt consumption presents a potential strategy to reduce the burden of cardiovascular disease.
Article
Environmental Sciences
Maria Averina, Jan Brox, Sandra Huber, Anne-Sofie Furberg
Summary: The study revealed a possible link between several PFAS and dyslipidemia, hypertension, and obesity in Norwegian adolescents, including substances like PFOS, PFNA, PFDA, PFUnDA, PFHxS, and PFOA.
ENVIRONMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Francesca Coccina, Anna M. Pierdomenico, Chiara Cuccurullo, Jacopo Pizzicannella, Oriana Trubiani, Sante D. Pierdomenico
Summary: The study aimed to assess the risk of heart failure in elderly treated hypertensive patients with different types of hypertension. The results showed that patients with uncontrolled hypertension, nonresistant hypertension, and resistant hypertension had a significantly higher risk of developing heart failure compared to those with controlled hypertension.
Article
Peripheral Vascular Disease
Giuseppe Mancia, Rita Facchetti, Gino Seravalle, Cesare Cuspidi, Giovanni Corrao, Guido Grassi
Summary: The addition of home and 24-hour blood pressure to office blood pressure significantly improves the prediction of cardiovascular and all-cause mortality, especially with the addition of home blood pressure. However, the quantitative improvement is modest, raising questions about the extended use of these methods in clinical practice.
Article
Peripheral Vascular Disease
Minjae Yoon, Seng Chan You, Jaewon Oh, Chan Joo Lee, Sang-Hak Lee, Seok-Min Kang, Sungha Park
Summary: The prognosis of refractory hypertension is worse than that of nonresistant and resistant hypertension, with a higher risk of cardiovascular mortality.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Felix Vaura, Anni Kauko, Karri Suvila, Aki S. Havulinna, Nina Mars, Veikko Salomaa, Susan Cheng, Teemu Niiranen
Summary: Genetic risk scores can improve the prediction of hypertension risk, especially early-onset hypertension, which is associated with significant cardiovascular disease risk. Combining BP PRS with traditional risk factors can enhance hypertension prediction strategies, as demonstrated in the study.
Article
Peripheral Vascular Disease
Kazuomi Kario, Naoko Tomitani, Satoshi Hoshide, Masafumi Nishizawa, Tetsuro Yoshida, Tomoyuki Kabutoya, Takeshi Fujiwara, Hiroyuki Mizuno, Yukie Okawara, Hiroshi Kanegae, HI JAMP Study Grp
Summary: Home blood pressure control status defined using different thresholds can predict the control status of 24-hour ambulatory blood pressure in treated hypertension. When home blood pressure is controlled to less than 125/75 mm Hg, ambulatory blood pressure is well controlled.
Review
Medicine, General & Internal
Yibang Cheng, Yan Li, Jiguang Wang
Summary: Ambulatory blood pressure monitoring is crucial in the management of hypertension, as it aids in accurate diagnosis and cardiovascular risk assessment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Peripheral Vascular Disease
Yiyi Zhang, Joseph E. Schwartz, Byron C. Jaeger, Jaejin An, Brandon K. Bellows, Donald Clark, Aisha T. Langford, Jolaade Kalinowski, Olugbenga Ogedegbe, John Jeffrey Carr, James G. Terry, Yuan-I. Min, Kristi Reynolds, Daichi Shimbo, Andrew E. Moran, Paul Muntner
Summary: The study suggests that higher diastolic BP and asleep SBP may be risk factors for subclinical atherosclerosis, highlighting the potential role of ambulatory BP monitoring in identifying individuals at high risk for coronary artery disease.
Article
Peripheral Vascular Disease
Eline H. Groenland, Jean-Paul A. C. Vendeville, Remy H. H. Bemelmans, Houshang Monajemi, Michiel L. Bots, Frank L. J. Visseren, Wilko Spiering
Summary: This study evaluated the agreement between app-assisted home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring, and found significant disagreement between the two methods. App-assisted home blood pressure monitoring had high sensitivity in diagnosing sustained and masked hypertension, and can be used as a complement to 24-hour ambulatory blood pressure monitoring.
Editorial Material
Cardiac & Cardiovascular Systems
Riccardo Sarzani, Federico Giulietti, Chiara Di Pentima, Piero Giordano, Francesco Spannella
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Riccardo Sarzani, Federico Giulietti, Chiara Di Pentima, Francesco Spannella
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2020)
Article
Multidisciplinary Sciences
Guido Iaccarino, Guido Grassi, Claudio Borghi, Stefano Carugo, Francesco Fallo, Claudio Ferri, Cristina Giannattasio, Davide Grassi, Claudio Letizia, Costantino Mancusi, Pietro Minuz, Stefano Perlini, Giacomo Pucci, Damiano Rizzoni, Massimo Salvetti, Riccardo Sarzani, Leonardo Sechi, Franco Veglio, Massimo Volpe, Maria Lorenza Muiesan
Article
Medicine, General & Internal
M. Casula, M. Gazzotti, F. Bonaiti, E. OImastroni, M. Arca, M. Averna, A. Zambon, A. L. Catapano
Summary: The PROSISA study found that 9.6% of dyslipidaemic patients reported statin-associated muscle symptoms (SAMS), with only one third of patients still reporting SAMS after dechallenge/rechallenge.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Medicine, General & Internal
Riccardo Sarzani, Francesco Spannella, Federico Giulietti, Chiara Di Pentima, Piero Giordano, Andrea Giacometti
Summary: The use of glucocorticoid drugs like dexamethasone for severe COVID-19 patients, especially those requiring mechanical ventilation or supplemental oxygen therapy, has shown the largest benefit. However, there may be no benefit for patients without hypoxemia. Administering dexamethasone after several days of symptoms can lead to positive outcomes, but early administration may have potential harm, with the optimum time for glucocorticoid administration still being debated.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
Riccardo Sarzani, Massimiliano Allevi, Federico Giulietti, Chiara Di Pentima, Serena Re, Piero Giordano, Francesco Spannella
Summary: Specific physiologic traits or health conditions like male sex, older age, overweight/obesity, arterial hypertension, metabolic syndrome, and type 2 diabetes mellitus have been found to be highly prevalent and associated with increased risk of adverse outcomes in hospitalized patients during the COVID-19 pandemic. These cardiovascular morbidities often coexist, leading to an imbalance in the RAS system and severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Francesco Spannella, Federico Giulietti, Roberta Galeazzi, Anna Passarelli, Serena Re, Chiara Di Pentima, Massimiliano Allevi, Paolo Magni, Riccardo Sarzani
Summary: This study found an inverse association between plasma PCSK9 and NT-proBNP levels in older patients, supporting the hypothesis that NPs may regulate cholesterol metabolism through inhibitory action on PCSK9 concentrations.
Review
Biochemistry & Molecular Biology
Riccardo Sarzani, Massimiliano Allevi, Chiara Di Pentima, Paola Schiavi, Francesco Spannella, Federico Giulietti
Summary: Cardiac natriuretic peptides are true hormones produced by cardiomyocytes, exerting systemic effects and contributing to cardiovascular health. They also have paracrine and autocrine activities on the heart, preventing cardiac dysfunction and promoting heart protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chiara Di Pentima, Sara Cecchini, Francesco Spannella, Federico Giulietti, Massimiliano Allevi, Paola Schiavi, Francesca Carnevali, Lorenzo Zoppi, Maria Carmela Ciociola, Fiammetta Ventura, Gina Dragano, Piero Giordano, Enrico Paci, Riccardo Sarzani
Summary: The aim of this study was to evaluate the lung sequelae and clinical consequences in older patients 3 and 6 months after hospitalization for COVID-19 pneumonia. The study included 55 patients aged 65 years and older. CT scans and assessments of daily living activities and clinical frailty were performed at baseline and after 3 and 6 months. The results showed that 22% of the subjects still had ground-glass opacities after 6 months, while consolidations were no longer visible. Fibrotic-like changes were found in 40% of the subjects, mainly males. Worsening daily living activities and clinical frailty were associated with comorbidities.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francesco Spannella, Federico Giulietti, Giorgia Laureti, Mirko Di Rosa, Chiara Di Pentima, Massimiliano Allevi, Caterina Garbuglia, Piero Giordano, Matteo Landolfo, Letizia Ferrara, Alessia Fumagalli, Fabrizia Lattanzio, Anna Rita Bonfigli, Riccardo Sarzani
Summary: This study aimed to identify clusters of hospitalized older COVID-19 patients and evaluate their association with in-hospital mortality. Three clusters were identified, with increasing mortality risk from cluster 1 to cluster 3. Patients in cluster 3 were older and had higher prevalence of comorbidities and inflammation markers. The addition of frailty assessment improved the predictive ability for in-hospital mortality.
Article
Peripheral Vascular Disease
Matteo Landolfo, Massimiliano Allevi, Francesco Spannella, Federico Giulietti, Alessandro Gezzi, Riccardo Sarzani
Summary: This study compared the CVR stratification and LDL-C control using different methods. The results showed that both SCORE2/SCORE2-OP and the 2021 ESC Guidelines led to significant reclassification of CVR and differences in LDL-C goals. The choice of LDL-C calculation method also had an impact on LDL-C control.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Review
Peripheral Vascular Disease
Federico Giulietti, Andrea Filipponi, Giulia Rosettani, Piero Giordano, Corrado Iacoacci, Francesco Spannella, Riccardo Sarzani
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2020)
Article
Medicine, General & Internal
Francesco Spannella, Letizia Ristori, Federico Giulietti, Serena Re, Paola Schiavi, Piero Giordano, Riccardo Sarzani
JOURNAL OF MEDICAL CASE REPORTS
(2020)
Article
Peripheral Vascular Disease
Francesco Spannella, Chiara Di Pentima, Federico Giulietti, Silvia Buscarini, Letizia Ristori, Piero Giordano, Riccardo Sarzani
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2020)