Review
Biochemistry & Molecular Biology
Pei-Fang Hsieh, Cheng-Chia Yu, Pei-Ming Chu, Pei-Ling Hsieh
Summary: This review focuses on the molecular mechanisms of lncRNA MEG3 as a signal, scaffold, guide, and decoy in regulating pluripotency, differentiation, and cancer stemness in various types of stem cells and cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Carmen Lanzillotti, Monica De Mattei, Chiara Mazziotta, Francesca Taraballi, John Charles Rotondo, Mauro Tognon, Fernanda Martini
Summary: Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in osteogenesis, regulating molecular pathways and influencing bone growth and development through their interactions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ruidong Li, Wenwen Zhang, Zhengjian Yan, Wei Liu, Jiaming Fan, Yixiao Feng, Zongyue Zeng, Daigui Cao, Rex C. Haydon, Hue H. Luu, Zhong-Liang Deng, Tong-Chuan He, Yulong Zou
Summary: mHotair plays a crucial role in BMP9-induced MSC osteogenesis by targeting cell cycle and proliferation, as demonstrated by increased expression in bones, and its regulation of osteogenic differentiation, chondrogenic markers, and adipogenic markers.
Article
Biotechnology & Applied Microbiology
Sebastien Riquier, Marc Mathieu, Chloe Bessiere, Anthony Boureux, Florence Ruffle, Jean-Marc Lemaitre, Farida Djouad, Nicolas Gilbert, Therese Commes
Summary: The study developed a dedicated bioinformatics pipeline to identify unannotated lncRNAs in MSCs, highlighting novel lncRNAs with high cell specificity. Through original and efficient methods for functional prediction, it was demonstrated that each candidate represents a specific state of MSC biology. The approach showed potential for utilizing lncRNAs as cell markers and suggested promising directions for future experimental investigations.
Review
Cell Biology
Jingyi Cai, Hexu Qi, Ke Yao, Yang Yao, Dian Jing, Wen Liao, Zhihe Zhao
Summary: The desire to delay or even reverse aging has never diminished. Mesenchymal stem cells (MSCs) with unique abilities are highlighted, but their senescence can lead to age-related diseases or compromised therapeutic outcomes. Non-coding RNAs (ncRNAs) play a crucial role in regulating cellular fate, and a systematic exploration of ncRNAs steering MSCs during senescence is urgently needed. This review discusses the relationship between senescence and MSCs, the role of ncRNAs in MSC senescence, and the clinical applications of ncRNA-based therapies in MSC-related fields.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Ting Wang, Zhaosheng Li, Liujia Yan, Feng Yan, Han Shen, Xinyu Tian
Summary: NBR2, a lincRNA adjacent to the tumor suppressor gene BRCA1, plays a crucial role in cancer by impacting glucose metabolism and various aspects of cancer progression, such as proliferation, metastasis, survival, and therapeutic resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xin Zhao, Jincheng Wu, Yongwen Li, Feng Ye, Chunyue Wang
Summary: The study found that lncRNA FENDRR can block the CSC-like traits in colorectal cancer cells by directly interacting with Sox2 mRNA 3'UTR, with its overexpression attenuating these traits and its knockdown enhancing them.
Article
Cell & Tissue Engineering
Hewei Xiong, Sen Ren, Jing Chen, Xiaofan Yang, Yutian Liu, Zhao Xu, Jiahe Guo, Tao Jiang, Meng Yuan, Yang Liu, Guolei Zhang, Wenqing Li, Hans-Guenther Machens, Zhenbing Chen
Summary: The lncRNA SAN mediates ASC senescence by regulating the miR-143-3p/ADD3 pathway, providing a potential target for rejuvenation of senescent ASCs and enhancement of wound repair.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell Biology
Jose Adan Gutierrez-Cruz, Vilma Maldonado, Jorge Melendez-Zajgla
Summary: Cancer stem cells are a cell population within malignant tumors with characteristics like self-renewal and drug resistance, regulated by various molecules such as lncRNAs. LncRNAs like HOTAIR, H19 have been described as key regulators of stemness in cancer, influencing cancer cells to acquire stem cell characteristics.
Review
Cardiac & Cardiovascular Systems
Yaoyao Guo, Xiaohui Feng, Dan Wang, Xiaonan Kang, Lu Zhang, Huihui Ren, Gang Yuan
Summary: Diabetes mellitus has become a global issue, with diabetic cardiomyopathy (DCM) being an important complication associated with the disease. Long non-coding RNAs (lncRNA) play a critical role in the molecular mechanism of DCM and may serve as potential diagnostic markers. This review summarizes the pathological roles and molecular mechanisms of lncRNA in diabetic cardiomyopathy, offering promising diagnosis and treatment strategies for DCM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Oncology
Shenqi Han, Yongqiang Qi, Yiming Luo, Xiaoping Chen, Huifang Liang
Summary: Exosomal lncRNAs, derived from both cancer cells and stromal cells, play a crucial role in promoting cancer progression by regulating gene expression and mediating the formation of pre-metastatic niches. Understanding the functions of exosomal lncRNAs in cancer development will provide valuable insights for cancer treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Md Nazim Uddin, Xiaosheng Wang
Summary: This review provides a comprehensive overview of the functional landscape of stroma-associated lncRNAs in various cancers, highlighting their crucial roles in regulating the tumor microenvironment and impacting cancer development and therapy. Dysregulation of stroma-associated lncRNAs significantly contributes to cancer initiation, progression, angiogenesis, immune evasion, metastasis, and drug resistance, suggesting their potential as valuable targets for cancer therapy.
Review
Cell Biology
Elham Oveili, Somayeh Vafaei, Haniyeh Bazavar, Yeganeh Eslami, Ehsan Mamaghanizadeh, Saman Yasamineh, Omid Gholizadeh
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by targeting mRNA. Changes in miRNA expression have been observed in various diseases. Anti-miRNAs can suppress miRNA function, while modified miRNA mimetics can enhance miRNA function. Exosomes (EXOs), specifically those derived from mesenchymal stem cells (MSC-EXOs), have shown promise as miRNA carriers due to their therapeutic efficiency and safety. This article provides a summary of miRNAs and MSC-EXOs, including their production, purification, and miRNA loading methods, as well as the modification of MSC-EXOs for targeted miRNA delivery in different diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Medicine, Research & Experimental
Salman Khan, Mohammad Masood, Harshita Gaur, Shaniya Ahmad, Mansoor Ali Syed
Summary: Long non-coding RNAs (lncRNAs) were once seen as genetic waste but are now recognized as important regulators of gene expression. Research has shown that lncRNAs play a key role in shaping immune cell function and response to disease, offering potential therapeutic targets for various illnesses.
Review
Cell Biology
Yanlei Yang, Suying Liu, Chengmei He, Zhilei Chen, Taibiao Lyu, Liuting Zeng, Li Wang, Fengchun Zhang, Hua Chen, Robert Chunhua Zhao
Summary: MSCs are promising candidates for stem cell-based therapies due to their properties of self-renewal, multi-differentiation, immunoregulation, and tissue maintenance. Long non-coding RNAs (lncRNAs) play a major role in regulating homeostasis and differentiation functions in MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
