Ion Channel Expression in Human Melanoma Samples: In Silico Identification and Experimental Validation of Molecular Targets

Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer’s disease

(2018) Xin Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Human pharmacological approaches to TRP-ion-channel-based analgesic drug development

(2018) Iris Weyer-Menkhoff et al.   DRUG DISCOVERY TODAY

Transition from androgenic to neurosteroidal action of 5α-androstane-3α, 17β-diol through the type A γ-aminobutyric acid receptor in prostate cancer progression

(2018) Ding Xia et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Combined targeted ion channel therapy: Can it be an alternative choice for esophageal cancer patients?

(2018) Guochao Zhang et al.   MEDICAL HYPOTHESES

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

(2018) Min He et al.   Translational Oncology

Morbidity and mortality associated with the interaction of miconazole oral gel and warfarin

(2018) M. N. Pemberton   BRITISH DENTAL JOURNAL

Effect of miconazole nitrate on immunological response and its preventive efficacy in Labeo rohita fingerlings against oomycetes Saprolegnia parasitica

(2018) Mukta Singh et al.   JOURNAL OF FISH DISEASES

Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats

(2018) Ning Li et al.   NEUROSCIENCE LETTERS

Tezacaftor for the treatment of cystic fibrosis

(2018) Marc A. Sala et al.   Expert Review of Respiratory Medicine

Immuno-Oncology: Emerging Targets and Combination Therapies

(2018) Henry T. Marshall et al.   Frontiers in Oncology

Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction

(2018) Mark A. Seefeld et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness

(2018) Stefania Rossi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers

(2018) Daniela D’Arcangelo et al.   Oxidative Medicine and Cellular Longevity

Cystic fibrosis: triple drug regimens that target defective ion channel improve lung function, studies show

(2018) Susan Mayor   BMJ-British Medical Journal

Epilepsy control with carbamazepine monotherapy from a genetic perspective

(2018) Shakir Ullah et al.   BMC Pharmacology & Toxicology

Perindopril arginine and amlodipine besylate for hypertension: a safety evaluation

(2017) William J. Elliott et al.   Expert Opinion On Drug Safety

Letter to the Editor: “Ion Channels in Brain Metastasis”—Ion Channels in Cancer Set up and Metastatic Progression

(2017) Daniela D’Arcangelo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF)

(2017) Eric Vancauwenberghe et al.   MOLECULAR CARCINOGENESIS

TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells

(2017) Alfredo I. Sagredo et al.   Molecular Oncology

Miconazole induces apoptosis via the death receptor 5-dependent and mitochondrial-mediated pathways in human bladder cancer cells

(2017) Sheau-Yun Yuan et al.   ONCOLOGY REPORTS

Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

(2017) Daniel Bauer et al.   Cell Death & Disease

TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

(2017) Jonathan Berrout et al.   Nature Communications

Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy

(2017) Feng Wei et al.   Neuroscience Bulletin

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways

(2017) Guanzhao Liang et al.   Oncotarget

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

(2017) Niedzica Camacho et al.   PLoS Genetics

Cardiovascular Ion Channel Inhibitor Drug-Drug Interactions with P-glycoprotein

(2016) Kaitlyn V. Ledwitch et al.   AAPS Journal

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

Ion channels expression and function are strongly modified in solid tumors and vascular malformations

(2016) Antonella Biasiotta et al.   Journal of Translational Medicine

Clinically Approved Ion Channel Inhibitors Close Gates for Hepatitis C Virus and Open Doors for Drug Repurposing in Infectious Viral Diseases

(2016) Thomas Pietschmann   JOURNAL OF VIROLOGY

Prophylactic efficacy of enteral miconazole administration for neonatal intestinal perforation and its potential mechanism

(2016) Motofumi Torikai et al.   PEDIATRIC SURGERY INTERNATIONAL

PDGFR-alpha inhibits melanoma growth via CXCL10/IP-10: a multi-omics approach

(2016) Daniela D’Arcangelo et al.   Oncotarget

Single Gene Prognostic Biomarkers in Ovarian Cancer: A Meta-Analysis

(2016) Scooter Willis et al.   PLoS One

The FDA approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

(2015) Chunkyu Ko et al.   ANTIVIRAL THERAPY

Involvement of potassium channels in the progression of cancer to a more malignant phenotype

(2015) Nuria Comes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of Miconazole on [Ca^(2+)]i and Cytotoxicity in ZR-75-1 Human Breast Cancer Cells

(2015) Cherng-Jau Roan   CHINESE JOURNAL OF PHYSIOLOGY

The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation

(2015) Bo Young Chung et al.   EXPERIMENTAL DERMATOLOGY

miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene

(2014) Zhenzhen Zhang et al.   ARCHIVES OF VIROLOGY

Recurrent read-through fusion transcripts in breast cancer

(2014) Katherine E. Varley et al.   BREAST CANCER RESEARCH AND TREATMENT

Modulation of KCa3.1 Channels by Eicosanoids, Omega-3 Fatty Acids, and Molecular Determinants

(2014) Michael Kacik et al.   PLoS One

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

(2014) Joseph D. Planer et al.   PLoS Neglected Tropical Diseases

Effects of Axonal Ion Channel Dysfunction on Quality of Life in Type 2 Diabetes

(2013) N. C. G. Kwai et al.   DIABETES CARE

Transcriptome Profiling Identifies HMGA2 as a Biomarker of Melanoma Progression and Prognosis

(2013) Leon Raskin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression profiling of ion channel genes predicts clinical outcome in breast cancer

(2013) Jae-Hong Ko et al.   Molecular Cancer

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Differential Denaturation of Serum Proteome Reveals a Significant Amount of Hidden Information in Complex Mixtures of Proteins

(2013) Vincenzo Verdoliva et al.   PLoS One

Tissue transglutaminase activity protects from cutaneous melanoma metastatic dissemination: an in vivo study

(2012) Francesco Facchiano et al.   AMINO ACIDS

Ion channel drug discovery: challenges and future directions

(2012) A Wickenden et al.   Future Medicinal Chemistry

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression

(2012) M Kappelmann et al.   ONCOGENE

Receiver Operating Characteristic Curve in Diagnostic Test Assessment

(2010) Jayawant N. Mandrekar   Journal of Thoracic Oncology

Endocytic control of ion channel density as a target for cardiovascular disease

(2009) Gail A. Robertson   JOURNAL OF CLINICAL INVESTIGATION

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

(2008) Adam I Riker et al.   BMC Medical Genomics

Connexin Expression and Functional Analysis of Gap Junctional Communication in Mouse Embryonic Stem Cells

(2007) Philipp Wörsdörfer et al.   STEM CELLS