Review
Pharmacology & Pharmacy
Xiaonan Xu, Ni Lu, Pan Song, Mingzhen Zhou, Yuanxiao Li, Zirui Wang, Xin Gao
Summary: This study evaluated the efficacy and safety of different treatments for methicillin-resistant Staphylococcus aureus (MRSA). The results showed that vancomycin or daptomycin combined with antistaphylococcal beta-lactam had slightly better efficacy than vancomycin or daptomycin alone, but with slightly higher adverse events. Other treatments, such as antistaphylococcal beta-lactam and trimethoprim-sulfamethoxazole, did not show significant advantages compared to vancomycin or daptomycin treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Cassandra Lew, Molly Pellitteri Hahn, Cameron Scarlett, Aaron Rottier, Andrew D. Berti, Richard A. Proctor, Arnold S. Bayer, Warren E. Rose
Summary: Clinical treatment options for daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) infections are limited. This study investigated the potential synergistic activity of daptomycin plus beta-lactams. The results showed that pre-treatment with beta-lactam antibiotics enhanced the activity of daptomycin in vitro. Proteomic analysis revealed differential modulation of metabolic and biosynthetic processes with beta-lactam pre-treatment. These findings suggest that beta-lactam pre-treatment can resensitize daptomycin-resistant MRSA strains to daptomycin-mediated killing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yasunori Iwata, Norihiko Sakai, Ikuko Yoneda, Yasuko Senda, Yukiko Sakai-Takemori, Megumi Oshima, Shiori Nakagawa-Yoneda, Hisayuki Ogura, Koichi Sato, Taichiro Minami, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kengo Furuichi, Kouji Matsushima, Takashi Wada
Summary: The study found that D-Ser reduces MRSA's attachment and biofilm formation by decreasing the expression of related genes. Additionally, the therapeutic potential of D-Ser in treating catheter infection in a mouse model was demonstrated. Therefore, D-Ser may serve as a promising therapeutic option for MRSA and E. coli infections.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
Shengnan Jiang, Hemu Zhuang, Feiteng Zhu, Xiang Wei, Junxiong Zhang, Lu Sun, Shujuan Ji, Haiping Wang, Dandan Wu, Feng Zhao, Rushuang Yan, Yunsong Yu, Yan Chen
Summary: The emergence of daptomycin-resistant Staphylococcus aureus strains is a global problem caused by point mutations in the mprF gene. This study found that specific mprF mutations lead to the seesaw effect of distinct beta-lactams in MRSA strains and the combination therapy of daptomycin and beta-lactams has synergistic activity. The cell surface positive charge is not affected by mprF mutations. Understanding the mechanism of restoring susceptibility to beta-lactam antibiotics mediated by mprF mutations is important for the treatment of MRSA infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Medicinal
Anka Lucic, Philip Hinchliffe, Tika R. Malla, Catherine L. Tooke, Jurgen Brem, Karina Calvopina, Christopher T. Lohans, Patrick Rabe, Michael A. McDonough, Timothy Armistead, Allen M. Orville, James Spencer, Christopher J. Schofield
Summary: Penems have shown potential as antibacterials and beta-lactamase inhibitors, but their clinical use is limited compared to carbapenems. Faropenem, with a C-2 tetrahydrofuran ring, is resistant to some beta-lactamases. Studies on reactions of faropenem with beta-lactamases demonstrate different outcomes, suggesting further research is needed for optimizing the interactions between penems and beta-lactamases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Infectious Diseases
Adrien Contejean, Mylene Tisseyre, Etienne Canoui, Jean-Marc Treluyer, Solen Kerneis, Laurent Chouchana
Summary: A disproportionality in reports of acute kidney injury was found in patients receiving vancomycin plus piperacillin compared to other vancomycin-containing regimens, suggesting a drug-drug interaction between these two antibiotics resulting in an increased risk of AKI.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
Christopher Campbell, Claire Fingleton, Merve S. Zeden, Emilio Bueno, Laura A. Gallagher, Dhananjay Shinde, Jongsam Ahn, Heather M. Olson, Thomas L. Fillmore, Joshua N. Adkins, Fareha Razvi, Kenneth W. Bayles, Paul D. Fey, Vinai C. Thomas, Felipe Cava, Geremy C. Clair, James P. 'Gara
Summary: Mutations in the TCA cycle gene sucC increased susceptibility to beta-lactam antibiotics in MRSA, accompanied by accumulation of succinyl-CoA and perturbation of lysine succinylation in the proteome. Interference with the MRSA succinylome may help overcome beta-lactam resistance through controlling cell wall phenotypes.
Article
Microbiology
Marta Toth, Mijoon Lee, Nichole K. Stewart, Sergei B. Vakulenko
Summary: Resistance to beta-lactams is a major problem in treating bacterial infections. In the case of Acinetobacter baumannii, resistance to beta-lactam antibiotics has resulted in the spread of multidrug-resistant isolates. This study found that PBP3 is essential for the survival of A. baumannii, and inhibiting PBP1a and PBP2, or PBPs in combination with LdtJ, could be potential strategies for designing new drugs against this pathogen.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Harshad Lade, Jae-Seok Kim
Summary: The development of antibiotic resistance in Staphylococcus aureus, particularly in MRSA, is a significant global health concern. The mecA gene, encoding PBP2a, is the main determinant of MRSA. Other genetic factors also play a role in beta-lactam resistance.
Article
Chemistry, Medicinal
Yin-Hwa Shih, Cheng-Chia Yu, Kai-Chi Chang, Yu-Hsin Tseng, Po-Jung Li, Shih-Min Hsia, Kuo-Chou Chiu, Tzong-Ming Shieh
Summary: The study found that the combination of temoporfin and KI significantly reduced the MICs and MBCs of Lactobacillus acidophilus and Lactobacillus paracasei under normal and hypoxic conditions, while increasing H2O2 production. Temoporfin improved biofilm removal of Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, and Staphylococcus aureus under normal oxygen conditions and reduced the expression of antibiotic resistance-related genes in MRSA. Combining temoporfin with ampicillin or chlorhexidine significantly enhanced the bactericidal effect on MRSA.
Article
Microbiology
Olga Lomovskaya, Debora Rubio-Aparicio, Ruslan Tsivkovski, Jeff Loutit, Michael Dudley
Summary: The study found that QPX7728 can effectively inhibit a wide range of beta-lactamases, and when combined with carbapenem tebipenem, cephalosporin ceftibuten, and amdinocillin, it can completely reverse beta-lactamase-mediated resistance. In laboratory strains and clinical isolates, the combination of tebipenem and ceftibuten with QPX7728 showed the lowest minimum inhibitory concentrations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Medicinal
Rachel Berndsen, Taylor Cunningham, Lauren Kaelin, Makayla Callender, W. Dexter Boldog, Brianna Viering, Ashley King, Najwa Labban, Julie A. Pollock, Heather B. Miller, Meghan S. Blackledge
Summary: Antibiotic-resistant infections are a global concern causing millions of deaths annually. Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections and is increasingly responsible for difficult-to-treat community-acquired infections. Antibiotic adjuvants, small molecules that enhance antibiotic efficacy through non-toxic mechanisms, show promise as novel therapeutics. Screening for low-molecular-weight compounds identified brominated carbazoles as lead compounds that potentiate beta-lactam antibiotics against medically relevant strains of MRSA by dampening the transcription of key resistance genes. These lead compounds represent novel scaffolds for the development of antibiotic adjuvants.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Applied
Nuno G. Alves, Americo J. S. Alves, Maria I. L. Soares, Teresa M. V. D. Pinho e Meloa
Summary: Spirocyclic molecules, especially the spiro-lactams subclass, are highly valued for their complex three-dimensional features and structural rigidity, making them extensively explored for their bioactivity and utility in various scientific fields such as drug design and organic synthesis. Efforts have been made towards developing new synthetic strategies for spirocyclic lactams due to their broad potential, with significant advancements reported since 2015 in the synthesis of spiro-beta-lactams and spiro-delta-lactams.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Infectious Diseases
Fatimah Muhammad Ballah, Md. Saiful Islam, Md. Liton Rana, Md. Ashek Ullah, Farhana Binte Ferdous, Fahim Haque Neloy, Samina Ievy, Md. Abdus Sobur, A. M. M. Taufiquer Rahman, Mst. Minara Khatun, Marzia Rahman, Md. Tanvir Rahman
Summary: This study aimed to investigate the virulence factors and methicillin resistance in biofilm-forming Staphylococcus aureus isolates from different foods and food handlers in Bangladesh. The results showed that these isolates carried various resistance genes and virulence factors, and exhibited resistance to multiple antibiotics. These findings suggest a potential threat to public health from biofilm-forming S. aureus in Bangladesh.
Article
Pharmacology & Pharmacy
Kaixuan Wang, Hao Lu, Xinmiao Wang, Qingxia Liu, Jinxia Hu, Yao Liu, Meihua Jin, Dexin Kong
Summary: Metabolic reprogramming is a characteristic of human cancer. The combination of PKM2-IN-1 and NCT-503 shows significant anti-cancer effects by inhibiting proliferation, inducing cell cycle arrest and apoptosis, and affecting multiple metabolic pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Chiara Indiani, Karen Sauve, Assaf Raz, Wessam Abdelhady, Yan Q. Xiong, Cara Cassino, Arnold S. Elayer, Raymond Schuch
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Genzhu Wang, Jing Pang, Xinxin Hu, Tongying Nie, Xi Lu, Xue Li, Xiukun Wang, Yun Lu, Xinyi Yang, Jiandong Jiang, Congran Li, Yan Q. Xiong, Xuefu You
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Microbiology
Selvi C. Ersoy, Wessam Abdelhady, Liang Li, Henry F. Chambers, Yan Q. Xiong, Arnold S. Bayer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Immunology
Liang Li, Genzhu Wang, Ambrose Cheung, Wessam Abdelhady, Kati Seidl, Yan Q. Xiong
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Pharmacology & Pharmacy
Genzhu Wang, Liang Li, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You, Yan Q. Xiong
ACTA PHARMACEUTICA SINICA B
(2019)
Article
Biochemistry & Molecular Biology
Yan Q. Xiong, Liang Li, Yufeng Zhou, Carl N. Kraus
Article
Microbiology
Selvi C. Ersoy, Mariam Otmishi, Vanessa T. Milan, Liang Li, Youngju Pak, Jose Mediavilla, Liang Chen, Barry Kreiswirth, Henry F. Chambers, Richard A. Proctor, Yan Q. Xiong, Vance G. Fowler, Arnold S. Bayer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
Warren E. Rose, Ana M. Bienvenida, Yan Q. Xiong, Henry F. Chambers, Arnold S. Bayer, Selvi C. Ersoy
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Microbiology
Yu-Feng Zhou, Liang Li, Meng-Ting Tao, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu, Yan Q. Xiong
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Microbiology
Sonia U. Shah, Yan Q. Xiong, Wessam Abdelhady, James Iwaz, Youngju Pak, Raymond Schuch, Cara Cassino, Dario Lehoux, Arnold S. Bayer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Liang Li, Arnold S. Bayer, Ambrose Cheung, Lou Lu, Wessam Abdelhady, Niles P. Donegan, Jong-In Hong, Michael R. Yeaman, Yan Q. Xiong
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Microbiology
Liang Li, Genzhu Wang, Yi Li, Patrice Francois, Arnold S. Bayer, Liang Chen, Kati Seidl, Ambrose Cheung, Yan Q. Xiong
Article
Multidisciplinary Sciences
Hongliang Zhao, Seth A. Brooks, Susan Eszterhas, Spencer Heim, Liang Li, Yan Q. Xiong, Yongliang Fang, Jack R. Kirsch, Eeptak Verma, Chris Bailey-Kellogg, Karl E. Griswold
Review
Infectious Diseases
Liang Li, Michael R. Yeaman, Arnold S. Bayer, Yan Q. Xiong