Analysis of Progress and Challenges of EGFR-Targeted Molecular Imaging in Cancer With a Focus on Affibody Molecules

A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management

(2018) Xilin Sun et al.   Science Translational Medicine

SPECT imaging evaluation of 111 indium-chelated cetuximab for diagnosing EGFR-positive tumor in an HCT-15-induced colorectal xenograft

(2017) Bin-Bin Shih et al.   Journal of the Chinese Medical Association

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

(2017) Judith van Loon et al.   RADIOTHERAPY AND ONCOLOGY

Development and Evaluation of 18F-IRS for Molecular Imaging Mutant EGF Receptors in NSCLC

(2017) Yan Song et al.   Scientific Reports

Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR:2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator

(2016) Ken G. Andersson et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PET imaging of epidermal growth factor receptor expression in tumours using 89Zr-labelled ZEGFR:2377 affibody molecules

(2016) JAVAD GAROUSI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Immuno-PET Imaging and Radioimmunotherapy of 64Cu-/177Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model

(2016) I. H. Song et al.   JOURNAL OF NUCLEAR MEDICINE

Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients

(2016) M. Sandstrom et al.   JOURNAL OF NUCLEAR MEDICINE

Enhanced tumor retention of radioiodinated anti-epidermal growth factor receptor antibody using novel bifunctional iodination linker for radioimmunotherapy

(2016) EUN JUNG KIM et al.   ONCOLOGY REPORTS

Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [68Ga]ABY-025 Affibody PET/CT

(2016) Jens Sörensen et al.   Theranostics

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

(2016) Qing Cheng et al.   EJNMMI Research

Predictive efficacy of11C-PD153035 PET imaging for EGFR-tyrosine kinase inhibitor sensitivity in non-small cell lung cancer patients

(2015) Dong Dai et al.   INTERNATIONAL JOURNAL OF CANCER

PET/CT-Derived Whole-Body and Bone Marrow Dosimetry of 89Zr-Cetuximab

(2015) N. E. Makris et al.   JOURNAL OF NUCLEAR MEDICINE

The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs

(2015) Yanna Tang et al.   Oncotarget

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

(2014) K. Azuma et al.   ANNALS OF ONCOLOGY

Fluorogen Activating Protein–Affibody Probes: Modular, No-Wash Measurement of Epidermal Growth Factor Receptors

(2014) Yi Wang et al.   BIOCONJUGATE CHEMISTRY

First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule

(2014) J. Sorensen et al.   JOURNAL OF NUCLEAR MEDICINE

An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas in the Setting of Colitis

(2014) N. Selcan Turker et al.   Theranostics

Affibody modified and radiolabeled gold–Iron oxide hetero-nanostructures for tumor PET, optical and MR imaging

(2013) Meng Yang et al.   BIOMATERIALS

Imaging of Epidermal Growth Factor Receptor Expression in Head and Neck Cancer with SPECT/CT and 111In-Labeled Cetuximab-F(ab')2

(2013) L. K. van Dijk et al.   JOURNAL OF NUCLEAR MEDICINE

Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

(2013) D. Bettenworth et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Comparison of Near-Infrared-Labeled Cetuximab and Panitumumab for Optical Imaging of Head and Neck Squamous Cell Carcinoma

(2013) Kristine E. Day et al.   MOLECULAR IMAGING AND BIOLOGY

Inert coupling of IRDye800CW and zirconium-89 to monoclonal antibodies for single- or dual-mode fluorescence and PET imaging

(2013) Ruth Cohen et al.   Nature Protocols

111In-cetuximab-F(ab’)2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts

(2013) Laura K. van Dijk et al.   RADIOTHERAPY AND ONCOLOGY

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

(2013) E. A. Akbay et al.   Cancer Discovery

Evaluation of Four Affibody-Based Near-Infrared Fluorescent Probes for Optical Imaging of Epidermal Growth Factor Receptor Positive Tumors

(2012) Shibo Qi et al.   BIOCONJUGATE CHEMISTRY

Intratumor Heterogeneity: Evolution through Space and Time

(2012) C. Swanton   CANCER RESEARCH

Discrepancies between primary tumor and metastasis: A literature review on clinically established biomarkers

(2012) Stéphane Vignot et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Epidermal growth factor receptor inhibits colitis-associated cancer in mice

(2012) Philip E. Dubé et al.   JOURNAL OF CLINICAL INVESTIGATION

Can EGFR-TKIs be used in first line treatment for advanced non-small cell lung cancer based on selection according to clinical factors ? -- A literature-based meta-analysis

(2012) Chongrui Xu et al.   Journal of Hematology & Oncology

PET of EGFR Expression with an 18F-Labeled Affibody Molecule

(2012) Z. Miao et al.   JOURNAL OF NUCLEAR MEDICINE

Intratumor Heterogeneity and Branched Evolution

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

PET imaging of EGF receptors using [18F]FBEM-EGF in a head and neck squamous cell carcinoma model

(2011) Weihua Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET

(2011) Maria J. W. D. Vosjan et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Molecular Imaging with 11C-PD153035 PET/CT Predicts Survival in Non-Small Cell Lung Cancer Treated with EGFR-TKI: A Pilot Study

(2011) X. Meng et al.   JOURNAL OF NUCLEAR MEDICINE

Non-small-cell lung cancer

(2011) Peter Goldstraw et al.   LANCET

Treatment of Non–Small-Cell Lung Cancer with Erlotinib or Gefitinib

(2011) Vince D. Cataldo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis

(2011) Annette K. Larsen et al.   PHARMACOLOGY & THERAPEUTICS

HER1-Targeted 86Y-Panitumumab Possesses Superior Targeting Characteristics than 86Y-Cetuximab for PET Imaging of Human Malignant Mesothelioma Tumors Xenografts

(2011) Tapan K. Nayak et al.   PLoS One

Inert coupling of IRDye800CW to monoclonal antibodies for clinical optical imaging of tumor targets

(2011) Ruth Cohen et al.   EJNMMI Research

Small-Animal PET Imaging of Human Epidermal Growth Factor Receptor Positive Tumor with a64Cu Labeled Affibody Protein

(2010) Zheng Miao et al.   BIOCONJUGATE CHEMISTRY

Influence of Labelling Methods on Biodistribution and Imaging Properties of Radiolabelled Peptides for Visualisation of Molecular Therapeutic Targets

(2010) V. Tolmachev et al.   CURRENT MEDICINAL CHEMISTRY

Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck

(2010) Mark E. Sharafinski et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Radiolabeled cetuximab: Dose optimization for epidermal growth factor receptor imaging in a head-and-neck squamous cell carcinoma model

(2010) Bianca A.W. Hoeben et al.   INTERNATIONAL JOURNAL OF CANCER

Cy5.5-labeled Affibody molecule for near-infrared fluorescent optical imaging of epidermal growth factor receptor positive tumors

(2010) Zheng Miao et al.   JOURNAL OF BIOMEDICAL OPTICS

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-ZEGFR:2377 Affibody molecule: aspect of the injected tracer amount

(2009) Vladimir Tolmachev et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In Vivo Molecular Imaging of Colorectal Cancer With Confocal Endomicroscopy by Targeting Epidermal Growth Factor Receptor

(2009) Martin Goetz et al.   GASTROENTEROLOGY

PET of EGFR Antibody Distribution in Head and Neck Squamous Cell Carcinoma Models

(2009) G. Niu et al.   JOURNAL OF NUCLEAR MEDICINE

Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial

(2009) Robert Pirker et al.   LANCET

Antagonistic effect of EGF on FAK phosphorylation/dephosphorylation in a cell

(2008) Sang‐Heon Kim et al.   CELL BIOCHEMISTRY AND FUNCTION

Directed Evolution to Low Nanomolar Affinity of a Tumor-Targeting Epidermal Growth Factor Receptor-Binding Affibody Molecule

(2008) Mikaela Friedman et al.   JOURNAL OF MOLECULAR BIOLOGY

Disparity Between In Vivo EGFR Expression and 89Zr-Labeled Cetuximab Uptake Assessed with PET

(2008) H. J.W.L. Aerts et al.   JOURNAL OF NUCLEAR MEDICINE

SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression

(2008) Lieven Huang et al.   MOLECULAR IMAGING AND BIOLOGY

Noninvasive Monitoring of Tumors

(2008) Joan H. Schiller   NEW ENGLAND JOURNAL OF MEDICINE