Article
Biochemistry & Molecular Biology
Hyeyoon Lee, Rui Sun, Christof Niehrs
Summary: Bone morphogenetic proteins (BMPs) play important roles in various biological processes, including embryogenesis and disease. Recent studies have found that R-spondin 2 (RSPO2) acts as a BMP receptor antagonist, and a peptide derived from RSPO2 can uncouple BMP antagonist function from WNT agonist function, showing potential for therapeutic development in diseases like acute myeloid leukemia (AML). By using a dendrimer based on this peptide, it is possible to selectively target BMP receptor signaling, reduce cell growth, and induce differentiation in AML cells, as well as modulate embryonic patterning in Xenopus embryos.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Saifang Fu, Rongbang Tan, Yufei Feng, Ping Yu, Yuqian Mo, Wei Xiao, Shouyu Wang, Jingjing Zhang
Summary: This study revealed that N-methyl-N-nitrosourea (MNU) induced aberrant angiogenesis through the modulation of the rspo1/Wnt/β-catenin/vegfaa axis. Furthermore, it was found that the pro-angiogenic effect of MNU on developing zebrafish embryos could be controlled through pharmacological manipulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
German Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Summary: RNF43/ZNRF3 alterations contribute to liver disease and liver cancer by affecting differentiation and lipid metabolism of hepatocytes. The loss of these genes leads to steatohepatitis and an increase in unsaturated lipids. Deletion of Rnf43/Znrf3 results in defective hepatocyte regeneration and liver cancer, causing an imbalance between differentiation and proliferation. Interestingly, ZNRF3 mutant liver cancer patients have a poorer prognosis and exhibit altered hepatic lipid metabolism and steatohepatitis/NASH signatures.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Dan Li, Yuting Guo, She Tian, Changhao Zhu, Chengyi Sun
Summary: This study reveals the pro-carcinogenic role of CAV2 in pancreatic cancer through the activation of the Wnt7A/beta-catenin signaling pathway. miR-4723 is identified as an oncogene in pancreatic cancer, inhibiting CAV2 expression. These findings provide new targets and mechanisms for the treatment of pancreatic cancer.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen, Liaobin Chen
Summary: This study demonstrates the ability of Morusin to promote osteogenic differentiation of BMSCs through activation of the Wnt/β-catenin signaling pathway, and suggests the potential of Morusin as a treatment for osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Plant Sciences
Younglim Son, Khong Trong Quan, Subeen Shin, Seoyoung Park, MinKyun Na, Sangtaek Oh
Summary: Rubia philippinensis and its active metabolite lucidin 3-methyl ether prevent cell proliferation in multiple myeloma by suppressing the Wnt/beta-catenin pathway, making them potential chemopreventive agents for the treatment of MM.
Article
Biology
Victor Martinez-Heredia, Danielle Blackwell, Sujith Sebastian, Timothy Pearson, Gi Fay Mok, Laura Mincarelli, Charlotte Utting, Leighton Folkes, Ernst Poeschl, Iain Macaulay, Ulrike Mayer, Andrea Munsterberg
Summary: Skeletal muscle stem cells play a crucial role in tissue homeostasis and repair. This study demonstrates that primary cilia and the Talpid3 gene are essential for self-renewal of muscle stem cells and proper muscle regeneration.
COMMUNICATIONS BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Shuxian Lin, Lingyan Cao, Qian Wang, Jiahui Du, Delong Jiao, Shengzhong Duan, Jiannan Wu, Qi Gan, Xinquan Jiang
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Nanoscience & Nanotechnology
Jiannan Wu, Ao Zheng, Yang Liu, Delong Jiao, Deliang Zeng, Xiao Wang, Lingyan Cao, Xinquan Jiang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Panpan Liu, Delong Jiao, Xiaoya Wang, Jing Liu, Domingo Martin, Jing Guo
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Jiannan Wu, Lingyan Cao, Yang Liu, Ao Zheng, Delong Jiao, Deliang Zeng, Xiao Wang, David L. Kaplan, Xinquan Jiang
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Nanoscience & Nanotechnology
Xianzhen Xin, Jiannan Wu, Ao Zheng, Delong Jiao, Yang Liu, Lingyan Cao, Xinquan Jiang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Chemistry, Physical
Delong Jiao, Jing Wang, Wenting Yu, Ning Zhang, Ke Zhang, Yuxing Bai
Summary: The biocompatible reduced graphene oxide can promote stem cells chondrogenic differentiation by delivering kartogenin efficiently.
Article
Cell & Tissue Engineering
Jing Wang, Delong Jiao, Xiaofeng Huang, Yuxing Bai
Summary: mBMMSCs can be recruited to the compressed side of the periodontal ligament and promote osteoclastogenesis by expressing Rankl, thus improving the efficiency of OTM.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Delong Jiao, Ao Zheng, Yang Liu, Xiangkai Zhang, Xiao Wang, Jiannan Wu, Wenjun She, Kaige Lv, Lingyan Cao, Xinquan Jiang
Summary: The gelatin-reduced graphene oxide composite can mimic natural bone healing process and promote rapid bone repair through regulating its ratio, inducing bi-differentiation of bone marrow stromal cells, and providing bioactive signals. This biomimetic composite shows promising potential in segmental bone defect repair with its ability to provide a conducive microenvironment for cell differentiation.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Delong Jiao, Jing Wang, Wenting Yu, Ke Zhang, Ning Zhang, Lingyan Cao, Xinquan Jiang, Yuxing Bai
Summary: This study evaluated the use of biocompatible gelatin reduced graphene oxide (GOG) to accelerate orthodontic tooth movement. The in vivo experiments on a mouse model showed that GOG injection promoted bone resorption and neovascularization, resulting in accelerated tooth movement. In vitro experiments demonstrated the good biocompatibility of GOG in bone marrow stromal stem cells (BMSCs) and confirmed that GOG injection did not affect the survival and life of animals. Furthermore, the study found that GOG-stimulated BMSCs regulated osteoclastogenesis and angiogenesis, with the PERK pathway playing an important role.
BIOACTIVE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Panpan Liu, Guangxue Wu, Jing Liu, Delong Jiao, Jing Guo
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)