Article
Immunology
Elizabeth S. Aby, Byron P. Vaughn, Eva A. Enns, Radha Rajasingham
Summary: This study assessed the cost-effectiveness of fecal microbiota transplantation (FMT) for first recurrent Clostridioides difficile infection (CDI). The findings indicate that FMT is a cost-effective treatment strategy for first recurrent CDI.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Olle Bjorkqvist, Ignacio Rangel, Lena Serrander, Cecilia Magnusson, Jonas Halfvarson, Torbjorn Noren, Malin Bergman-Jungestrom
Summary: The study found that FMT can increase the relative abundance of Faecalibacterium prausnitzii in patients with recurrent CDI, and this microbial shift persists for several months later. Further research is needed to determine whether Faecalibacterium prausnitzii actively contributes to the resolution of CDI.
Article
Gastroenterology & Hepatology
Kelsey E. Huus, Marcin Frankowski, Maja Pucic-Bakovic, Frano Vuckovic, Gordan Lauc, Benjamin H. Mullish, Julian R. Marchesi, Tanya M. Monaghan, Dina Kao, B. Brett Finlay
Summary: This study found that IgA-bacterial interactions are reestablished in human FMT recipients to resemble that of the healthy fecal donor. The data suggests that the IgA-bacterial interactions are influenced by the bacterial species and the fecal donor identity in the FMT recipients.
Article
Gastroenterology & Hepatology
Byron P. Vaughn, Monika Fischer, Colleen R. Kelly, Jessica R. Allegretti, Carolyn Graiziger, Juana Thomas, Emma McClure, Amanda J. Kabage, Alexander Khoruts
Summary: This study aimed to evaluate the safety and effectiveness of capsule FMT (cap-FMT) and colonoscopy FMT (colo-FMT) for multiply recurrent Clostridioides difficile infections (rCDIs). The results showed that cap-FMT has a similar safety and effectiveness profile compared with colo-FMT, without the procedural risks of colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Krishna Vedala, Philip Sobash, Parth Shah, Gilbert-Roy Kamoga
Summary: Clostridioides difficile infection imposes a significant economic burden in inpatient and rural settings. Fecal Microbiota Transplant, although limited by guidelines and resources, has been shown to save an average of $11,603.49 per patient after the first recurrence of CDI. Our study suggests that utilizing FMT in rural hospitals for recurrent CDI treatment could be economically beneficial.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Gastroenterology & Hepatology
Christian Bestfater, Maria J. G. T. Vehreschild, Andreas Stallmach, Kester Tueffers, Andreas Erhardt, Thorsten Frank, Thomas Glueck, Felix Goeser, Gernot Sellge, Philipp Solbach, Herbert Eisenlohr, Martin Storr
Summary: Simultaneous bidirectional FMT showed superior primary cure rates compared to standard unidirectional approaches for recurrent Clostridioides difficile infection, highlighting the importance of treatment route in optimizing patient outcomes. Further prospective studies are needed to confirm these findings.
DIGESTIVE AND LIVER DISEASE
(2021)
Letter
Medicine, General & Internal
Nicolas Benech, Tatiana Galperine, Harry Sokol
Summary: This article compares the efficacy of SER-109 and fecal microbiota transplantation (FMT) in preventing recurrent Clostridioides difficile infection. The recurrence rate was lower than expected in the placebo group, while FMT showed benefits in preventing recurrent C. difficile infection among patients with a history of multiple cases.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Yichun Fu, Yuying Luo, Ari M. Grinspan
Summary: Clostridioides difficile infection is a major issue in healthcare settings, with a rising incidence of community-associated infections. Patients with community-associated C. difficile tend to be younger with lower mortality rates. Although rates of recurrent C. difficile infection have decreased in the United States, further research and public health efforts are needed to address the changing epidemiology of this disease.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Christian Lodberg Hvas, Tine Rask Licht
Summary: This study aimed to explore the relationship between early changes in the intestinal microbiota and clinical outcomes following fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (CDI). The results showed that patients with sustained resolution after FMT had different microbial diversity, abundance, and gut microbiota dysbiosis compared to non-responders. Additionally, a constructed index based on clinically feasible methods successfully predicted treatment failure. It was also found that FMT had a more pronounced impact on the gut microbiota compared to antibiotic monotherapy. Therefore, early identification of microbial community structures after FMT is clinically valuable for predicting treatment response.
Article
Gastroenterology & Hepatology
Maribeth R. Nicholson, Suchitra K. Hourigan, Maire Conrad, Alka Goyal, Kyle Jensen, Judith Kelsen, Melissa Kennedy, Madison Weatherly, Stacy A. Kahn
Summary: The impact of the 2019 US FDA safety alert and the COVID-19 pandemic on the use of FMT in children has led to changes in practices for many pediatric gastroenterologists, with a majority of programs being halted as a result.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Anna Maria Seekatz, Nasia Safdar, Sahil Khanna
Summary: The composition of the human gut microbiota is important for overall health, and disruptions in this microbiome can lead to various diseases. In the case of Clostridioides difficile infection, standard treatments and monoclonal antibodies do not address the underlying dysbiosis. Fecal microbiota transplantation (FMT) is an effective strategy in preventing recurrent infections, but there are challenges in screening and standardizing the acquisition and processing of donor stool. Newer biotherapeutic formulations are being developed to improve gut microbiome restoration and prevent CDI recurrence.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Lucas F. Soveral, Gabriela G. Korczaguin, Pedro S. Schmidt, Isabel S. Nunes, Camilo Fernandes, Carlos R. Zarate-Blades
Summary: Fecal microbiota transplantation (FMT) is a successful method for treating recurrent Clostridioides difficile (C. difficile) infection. It works through direct mechanisms against C. difficile and indirect mechanisms involving the production of secondary bile acids and short chain fatty acids. Furthermore, FMT can modulate the inflammatory response triggered by C. difficile by regulating regulatory T cells, resulting in the normalization of the intestinal mucosal immune system.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Adrian Boicean, Bogdan Neamtu, Sabrina Birsan, Florina Batar, Ciprian Tanasescu, Horatiu Dura, Mihai Dan Roman, Adrian Hasegan, Dan Bratu, Alin Mihetiu, Calin Ilie Mohor, Cosmin Mohor, Ciprian Bacila, Mihai Octavian Negrea, Sorin Radu Fleaca
Summary: In this comparative study on 86 patients with co-infection of COVID-19 and Clostridioides Difficile, fecal microbiota transplantation (FMT) showed better results in terms of inflammatory markers, relapse rate, and symptom relief compared to antibiotic treatment alone. Therefore, FMT may be an effective treatment for improving patients' quality of life and inflammatory syndrome.
Review
Medicine, General & Internal
S. Khanna
Summary: Clostridioides difficile infection (CDI) is a common healthcare-associated infection, with management difficulties and high rates of recurrence. Microbiota restoration therapies, such as faecal microbiota transplantation, are the cornerstone for preventing recurrent CDI, with success rates over 90%. Developments in standardized microbiota restoration therapies, such as capsule-based and enema-based therapies, are emerging to improve management of CDI.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Avnish Sandhu, Teena Chopra
Summary: Clostridioides difficile infection (CDI) is a major cause of hospital-acquired infections, with recurrent CDI (rCDI) posing a challenge in treatment. Fecal microbiota transplantation (FMT) is suggested for second episodes of rCDI, showing promise compared to traditional treatments like vancomycin or fidaxomicin. However, concerns over infections, adverse events, and new diagnoses remain, requiring further study for long-term safety and efficacy of FMT in clinical practice.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Christian Schulz, Behnam Kalali, Alexander Link, Markus Gerhard, Peter Malfertheiner
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rokas Lukosevicius, Simonas Juzenas, Violeta Salteniene, Ugne Kulokiene, Justina Arstikyte, Georg Hemmrich-Stanisak, Andre Franke, Alexander Link, Paulius Ruzgys, Saulius Satkauskas, Henrikas Pauzas, Tadas Latkauskas, Gediminas Kiudelis, Francesc Balaguer, Juozas Kupcinskas, Jurgita Skieceviciene
Summary: This study explored regulatory changes in early colorectal cancer development and identified differentially expressed miRNAs using small RNA-seq profiling of colon biopsy samples. Functional experiments revealed the oncogenic effect of hsa-miR-1246 and its involvement in regulating the expression of tumor suppressors AXIN2 and CFTR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ramiro Vilchez-Vargas, Franz Salm, Eva B. Znalesniak, Katharina Haupenthal, Denny Schanze, Martin Zenker, Alexander Link, Werner Hoffmann
Summary: This study examines the spatial distribution of bacterial flora in the murine alimentary tract and its correlation with Tff3 deficiency and colitis. The results show variations in bacterial species richness and community structure along different regions of the tract. Interestingly, while Tff3 deficiency is linked to increased colitis, it does not significantly affect the bacterial communities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R. Morling, Indra Neil Guha, Eleanor Barnes, M. Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sacha A. Mueller, Marsha Yvonne Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Summary: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis.
Article
Gastroenterology & Hepatology
Aurelien Amiot, Jean-Francois Rahier, Filip Baert, Stephane Nahon, Ailsa Hart, Nikos Viazis, Livia Biancone, Eugeni Domenech, Catherine Reenears, Laurent Peyrin-Biroulet, Laurent Beaugerie, Johan Burisch
Summary: This study reports on the impact of the COVID-19 outbreak in patients with inflammatory bowel disease (IBD). The results show that the risk of COVID-19 and severe COVID-19 is not increased in IBD patients compared to the general population. There is also no negative impact of IBD-related medication on the risk of COVID-19 or severe COVID-19. Additionally, the COVID-19 outbreak led to a decrease in endoscopic and imaging procedures, but did not affect clinical activity and treatment.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jan Raabe, Kim M. Kaiser, Michael ToVinh, Claudia Finnemann, Philipp Lutz, Christoph Hoffmeister, Jenny Bischoff, Felix Goeser, Dominik J. Kaczmarek, Tim R. Glowka, Steffen Manekeller, Arthur Charpentier, Bettina Langhans, Hans Dieter Nischalke, Marieta Toma, Christian P. Strassburg, Ulrich Spengler, Ali T. Abdallah, Benjamin Kramer, Jacob Nattermann
Summary: In this study, researchers performed a detailed characterization of intrahepatic innate lymphoid cells (ILCs) in healthy and fibrotic livers, and identified a previously undescribed subset of ILC3-like cells that produce IL-13. These cells were enriched in human liver and increased in fibrotic livers. IL-13 production by ILC3 induced proinflammatory gene upregulation in hepatic stellate cells, suggesting a potential role in the modulation of chronic liver disease.
Article
Gastroenterology & Hepatology
Katrin Bose, Florian G. Scurt, Cosima Thon, Sabine Franke, Christian Schulz, Peter Malfertheiner, Alexander Link
Summary: This study aimed to evaluate DNA methylation as a diagnostic tool for differentiating between benign and malignant ascites. The results showed that methylation levels were associated with ascites in patients with tumors, but not in patients without tumors. In addition, inflammatory cells were also found to be related to DNA methylation changes.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2023)
Article
Engineering, Environmental
Cristina Povedano-Priego, Fadwa Jroundi, Pier L. Solari, Isabel Guerra-Tschuschke, Maria del Mar Abad-Ortega, Alexander Link, Ramiro Vilchez-Vargas, Mohamed L. Merroun
Summary: In this study, the impact of bentonite microbial communities on the allotropic transformation of Se(IV) bioreduction products under DGR relevant conditions was investigated. Moreover, the Se amendment-dependent shifts in the bentonite microbial populations were assessed. The results showed that the bentonite color changed from orange to black after selenite treatment, and the allotropic changes of Se bioreduction products were tracked using analytical techniques. The distribution of strains involved in Se(IV) reduction and Se(0) allotropic biotransformation potential was identified.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Darja Nikitina, Konrad Lehr, Ramiro Vilchez-Vargas, Laimas Virginijus Jonaitis, Mindaugas Urba, Juozas Kupcinskas, Jurgita Skieceviciene, Alexander Link
Summary: This study characterized the microbiota of gastric cancer using 16S rRNA gene and its transcript and identified differences in bacterial composition. The results showed that there was only partial overlap between DNA and RNA samples and differences between gastric cancer patients and healthy controls depending on the chosen sequencing modality. Furthermore, RNA sequencing was more sensitive for detecting differences in bacterial richness and specific bacteria. Overall, the choice of sequencing modality affects the characterization of the microbiota and the differences between case and control.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Andreas Stallmach, Lutz von Mueller, Martin Storr, Alexander Link, Peter C. C. Konturek, Philipp Christoph Solbach, Karl Heinz Weiss, Steffen Wahler, Maria J. G. T. Vehreschild
Summary: The frequency of FMT use in Germany is lower compared to other European countries. One of the obstacles is the regulatory classification of FMT as a non-approved drug, resulting in higher costs and reimbursement difficulties. The proposed regulation by the European Commission to classify FMT as a transplant may change the regulatory situation in Germany and promote nationwide availability of this recommended therapeutic procedure.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Gastroenterology & Hepatology
Wolfgang Fischbach, Jan Bornschein, Jorg C. Hoffmann, Sibylle Koletzko, Alexander Link, Lukas Macke, Peter Malfertheiner, Kerstin Schuette, Dieter-Michael Selgrad, Sebastian Suerbaum, Christian Schulz
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Microbiology
Baptiste Oosterlinck, Hannah Ceuleers, Wout Arras, Joris G. De Man, Karen Geboes, Heiko De Schepper, Marc Peeters, Sarah Lebeer, Jurgita Skieceviciene, Georgina L. Hold, Juozas Kupcinskas, Alexander Link, Benedicte Y. De Winter, Annemieke Smet
Summary: This study identified the mucin-microbiome signatures in gastric adenocarcinomas and their impact on clinical outcomes. The findings showed that intestinal mucin phenotype and high-level MUC13 expression were associated with poor survival, while gastric MUC5AC or MUC6 abundance was associated with a more favorable outcome. Furthermore, oral bacteria such as Neisseria, Prevotella, and Veillonella were found to play a potential role in MUC13 signaling and were associated with intestinal and mixed mucin phenotype tumors.
Article
Medicine, General & Internal
Jastin Link, Cosima Thon, Vytenis Petkevicius, Ruta Steponaitiene, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: This study aimed to evaluate the clinical relevance of xeno-miRNA miR-168 in the gastric mucosa during preneoplastic conditions and gastric carcinogenesis. The results showed that miR-168 levels were higher in patients with moderate and severe intestinal metaplasia, suggesting its potential involvement in mucosal lesions and gastric cancer development.
Article
Endocrinology & Metabolism
Francisco J. Osuna-Prieto, Huiwen Xu, Lourdes Ortiz-Alvarez, Xinyu Di, Isabelle Kohler, Lucas Jurado-Fasoli, Jose Rubio-Lopez, Julio Plaza-Diaz, Ramiro Vilchez-Vargas, Alexander Link, Angel Gil, Jonatan R. Ruiz, Patrick C. N. Rensen, Borja Martinez-Tellez
Summary: The study investigated the relationship between fecal microbiota diversity and composition and plasma bile acid levels in young adults. The results showed that fecal microbiota diversity and evenness, as well as the relative abundance of Firmicutes and Bacteroidetes phyla, were positively associated with plasma levels of secondary bile acids. However, further investigations are needed to confirm whether gut microbiota composition can regulate plasma bile acid concentrations in humans.