Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue

The Genetic and Molecular Bases for Hypertrophic Cardiomyopathy: The Role for Calcium Sensitization

(2018) Xianfeng Ren et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin

(2018) Alice Sheehan et al.   Frontiers in Physiology

S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue

(2018) Simon Braumann et al.   Frontiers in Physiology

Lost in translation: Interpreting cardiac muscle mechanics data in clinical practice

(2018) Ranganath Mamidi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models

(2017) Jiyan Mohammad et al.   Oncotarget

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model

(2017) Sabrina Stücker et al.   Frontiers in Physiology

Evaluation of MYBPC3 trans -Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes

(2017) Maksymilian Prondzynski et al.   Molecular Therapy-Nucleic Acids

Technical report: gadoxetate-disodium-enhanced 2D R2* mapping: a novel approach for assessing bile ducts in living donors

(2017) Soudabeh Fazeli Dehkordy et al.   Abdominal Radiology

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation

(2016) Andrew E. Messer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples

(2016) Roddy Walsh et al.   GENETICS IN MEDICINE

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

(2016) James A. Spudich et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue

(2016) Paul J.M. Wijnker et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epigallocatechin-3-Gallate Accelerates Relaxation and Ca2+ Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice

(2016) Felix W. Friedrich et al.   Frontiers in Physiology

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effectsin vivoin a mouse model of hypertrophic cardiomyopathy

(2015) Frederik Flenner et al.   CARDIOVASCULAR RESEARCH

Genetic advances in sarcomeric cardiomyopathies: state of the art

(2015) C. Y. Ho et al.   CARDIOVASCULAR RESEARCH

Uncoupling of myofilament Ca2+sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate

(2015) Maria Papadaki et al.   CARDIOVASCULAR RESEARCH

Targets for therapy in sarcomeric cardiomyopathies

(2015) J. C. Tardiff et al.   CARDIOVASCULAR RESEARCH

Green Tea Catechin Normalizes the Enhanced Ca2+Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy–Associated Mutation in Human Cardiac Troponin I (K206I)CLINICAL PERSPECTIVE

(2015) Chad M. Warren et al.   Circulation-Cardiovascular Genetics

Green Tea Catechin Normalizes the Enhanced Ca2+Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy–Associated Mutation in Human Cardiac Troponin I (K206I)CLINICAL PERSPECTIVE

(2015) Chad M. Warren et al.   Circulation-Cardiovascular Genetics

Genetics of Hypertrophic and Dilated Cardiomyopathy

(2015) Felix W. Friedrich et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Significance of Sarcomere Gene Mutations Analysis in the End-Stage Phase of Hypertrophic Cardiomyopathy

(2014) Elena Biagini et al.   AMERICAN JOURNAL OF CARDIOLOGY

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy

(2014) David Barefield et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Automated analysis of contractile force and Ca2+ transients in engineered heart tissue

(2014) Andrea Stoehr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Desensitization of Myofilaments to Ca2+ as a Therapeutic Target for Hypertrophic Cardiomyopathy With Mutations in Thin Filament Proteins

(2014) M. L. Alves et al.   Circulation-Cardiovascular Genetics

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy

(2014)   EUROPEAN HEART JOURNAL

Advances in medical treatment of hypertrophic cardiomyopathy

(2014) Mareomi Hamada et al.   Journal of Cardiology

Hypertrophic Cardiomyopathy

(2014) Barry J. Maron et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2014) Atsushi Tanaka et al.   Journal of the American Heart Association

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

(2012) Roberto Spoladore et al.   EUROPEAN HEART JOURNAL

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

(2012) Bodvaël Fraysse et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy

(2011) Houman Ashrafian et al.   CIRCULATION RESEARCH

Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function

(2011) Sabine J. van Dijk et al.   Circulation-Heart Failure

Double or compound sarcomere mutations in hypertrophic cardiomyopathy: A potential link to sudden death in the absence of conventional risk factors

(2011) Barry J. Maron et al.   HEART RHYTHM

2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy

(2011) Bernard J. Gersh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond

(2010) Akinori Kimura   JOURNAL OF HUMAN GENETICS

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility

(2010) Sabine Huke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

(2009) Viola Kooij et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

Nonsense-Mediated mRNA Decay and Ubiquitin–Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice

(2009) Nicolas Vignier et al.   CIRCULATION RESEARCH

Solution Structure of Human Cardiac Troponin C in Complex with the Green Tea Polyphenol, (−)-Epigallocatechin 3-Gallate

(2009) Ian M. Robertson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From genotype to phenotype: a longitudinal study of a patient with hypertrophic cardiomyopathy due to a mutation in the MYBPC3 gene

(2009) Adam Jacques et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex

(2008) Bradley M. Palmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice

(2008) Franz Baudenbacher et al.   JOURNAL OF CLINICAL INVESTIGATION