Article
Microbiology
Christina Nowicki, Lucille Ray, Philip Engen, Andrea Madrigrano, Thomas Witt, Thomas Lad, Melody Cobleigh, Ece A. Mutlu
Summary: The aim of this study is to compare the composition of the gut microbiome in three different sample types in women using bacterial 16S rRNA sequencing. The results show that different sampling methods can impact the results, highlighting the importance of considering the sampling method when studying the gut microbiome.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Han Yao, Hao Yang, Yueying Wang, Qian Xing, Lin Yan, Yaru Chai
Summary: The structure of gut microbiome in SLE patients with depression was found to be altered, and specific fecal microbes and metabolites were identified that may be involved in the development of depression. Elevated serum levels of IL-2 and IL-6 and decreased BDNF were associated with depression development in SLE patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Humna Liaqat, Amna Parveen, Sun-Yeou Kim
Summary: Modern neurological approaches have allowed for detailed studies on the physiology and treatment of depression. An imbalance in the microbiota-gut-brain axis contributes to the development of depression. This comprehensive review examines the antidepressive effects of therapeutic natural products and their derivatives that target brain-derived neurotrophic factor (BDNF) and its receptor in the gut-brain axis, providing valuable information for the development of novel antidepressant drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
J. H. Lipinski, X. Zhou, S. J. Gurczynski, J. R. Erb-Downward, R. P. Dickson, G. B. Huffnagle, B. B. Moore, D. N. O'Dwyer
Summary: The study found that mice with the same genotype exhibited limited changes in gut microbiota composition when cohoused, while mice randomly assigned to cages showed extensive microbiota changes. This suggests that the environment plays a significant role in shaping the gut microbiota composition independent of innate immunity factors.
INFECTION AND IMMUNITY
(2021)
Review
Nutrition & Dietetics
Ewelina Mlynarska, Joanna Gadzinowska, Julita Tokarek, Joanna Forycka, Aleksandra Szuman, Beata Franczyk, Jacek Rysz
Summary: This review investigates the impact of gut microbiota on the development of depression and the underlying molecular mechanisms. There are two possible pathways in which this interaction might occur, one suggesting that depressive disorder could lead to dysbiosis and the other considering if changes in gut microbiota might cause depressive disorder. The mechanisms responsible for this interaction include the secretion of neurotransmitters, gut peptides, and the activation of the immune system. However, more research is needed to explore the direct mechanisms of the interaction between gut microbiota and mental health.
Article
Psychiatry
Qi Zhang, Yajun Yun, Huimei An, Wenxuan Zhao, Ting Ma, Zhiren Wang, Fude Yang
Summary: The study investigated the gut microbiota composition and sleep quality of patients with MDD, finding that Dorea was associated with depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Gut microbiota alterations may potentially serve as biomarkers and treatment targets for sleep quality in MDD patients.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Clinical Neurology
Jane A. Foster, Glen B. Baker, Serdar M. Dursun
Summary: Understanding the role of the immune system and gut microbiome in major depressive disorder is crucial for improving treatment and prevention strategies. Interventions targeting gut microbes have shown promise in preclinical studies and may hold potential for treating MDD, but large clinical trials are needed to confirm their effectiveness. Further research on the gut microbiome-immune system-brain axis is necessary to uncover new treatment targets and improve outcomes for individuals with MDD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychiatry
Qi Zhang, Yajun Yun, Huimei An, Wenxuan Zhao, Ting Ma, Zhiren Wang, Fude Yang
Summary: This study revealed a potential mechanistic link between major depressive disorder (MDD) and daytime dysfunction through the gut-brain axis. The composition of the gut microbiome was found to be different in Chinese patients with MDD compared to healthy controls. These findings provide insights into the potential microbiota changes that occur in MDD and can contribute to the development of targeted therapeutic strategies for the various symptoms of depression.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Review
Behavioral Sciences
Julie Kristine Knudsen, Caspar Bundgaard-Nielsen, Simon Hjerrild, Rene Ernst Nielsen, Peter Leutscher, Suzette Sorensen
Summary: Gut microbiota in patients with MDD differs significantly from healthy controls, with variations in alpha and beta diversity, as well as specific changes in the relative abundance of certain bacteria. The heterogeneity in findings may be attributed to differences in study design and methodology.
BRAIN AND BEHAVIOR
(2021)
Article
Psychiatry
Zaiquan Dong, Xiaoling Shen, Yanni Hao, Jin Li, Haoran Li, Haizheng Xu, Li Yin, Weihong Kuang
Summary: The study identified significant differences in microbiota richness and diversity in general anxiety disorder (GAD) compared to the healthy control group, as well as distinct differences in gut microbiota composition between major depressive disorder (MDD) and GAD. These findings could help facilitate the differential diagnosis and targeted therapy for MDD and GAD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Environmental Sciences
Miaomiao Teng, Xiaoli Zhao, Lingfeng Zhou, Hong Yan, Lihui Zhao, Jiaqi Sun, Yunxia Li, Wentao Zhu, Fengchang Wu
Summary: This study investigated the impact of nanoplastics with differential charges on intestinal impairment and their relationship with the gut microbiome and fecal metabolites. The results showed that exposure to nanoplastics with different charges altered the abundance of specific gut bacteria and caused intestinal impairment. By analyzing fecal metabolites, potential biomarkers for predicting intestinal impairment were identified.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Neurosciences
Christa Corley, Taylor McElroy, Bhavana Sridharan, Madison Trujillo, Pilar Simmons, Sangam Kandel, Delawrence J. Sykes, Michael S. Robeson II, Antino R. Allen
Summary: CMF treatment induced social and despair-like behavior in mice. The proteomic analysis revealed changes in proteins related to progressive neurological disease, working memory deficit, and primary anxiety disorder in the hippocampus and amygdala. Additionally, immediate changes in the gut microbiota were observed after chemotherapy treatment, with notable increases in the abundance of Muribaculaceae and Romboutsia.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Wen-tao Lai, Wen-feng Deng, Shu-xian Xu, Jie Zhao, Dan Xu, Yang-hui Liu, Yuan-yuan Guo, Ming-bang Wang, Fu-sheng He, Shu-wei Ye, Qi-fan Yang, Tie-bang Liu, Ying-li Zhang, Sheng Wang, Min-zhi Li, Ying-jia Yang, Xin-hui Xie, Han Rong
Summary: This study found changes in gut microbiota and the Trp pathway in MDD patients, with an increase in Bifidobacterium levels and decreased abundances of certain KEGG orthologies in the MiTBamp. A negative correlation was also observed between K01626 abundance and HAMD scores in the MDD group. The findings suggest that alterations in gut microbiota could potentially serve as biomarkers for distinguishing MDD patients from healthy controls.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Manoj P. Dandekar, Mani Surya Kumar Palepu, Srilakshmi Satti, Yash Jaiswal, Aditya A. Singh, Surya Prakash Dash, Siva Nageswara Rao Gajula, Rajesh Sonti
Summary: Depression is a debilitating mental disorder affecting over 322 million people globally, with many patients being refractory to current antidepressant treatments. Recent literature suggests a possible role of gut microbiota in neuropsychiatric disorders. A study on Sprague-Dawley rats found that a multi-strain probiotic formulation showed potential in alleviating anxiety and depression-like phenotypes induced by early- and late-life stress.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Penghong Liu, Mingxue Gao, Zhifen Liu, Yanyan Zhang, Hongwei Tu, Lei Lei, Peiyi Wu, Aixia Zhang, Chunxia Yang, Gaizhi Li, Ning Sun, Kerang Zhang
Summary: This study found that the gut microbiota composition in patients with major depressive disorder is associated with inflammatory factors and cognitive function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
A. L. A. Neves, Y. Chen, K-A Le Cao, S. Mandal, T. J. Sharpton, T. McAllister, L. L. Guan
Article
Biotechnology & Applied Microbiology
Amita Kashyap, Adelaide Rhodes, Brent Kronmiller, Josie Berger, Ashley Champagne, Edward W. Davis, Mitchell Finnegan, Matthew Geniza, David A. Hendrix, Christiane Loehr, Vanessa M. Petro, Thomas J. Sharpton, Jackson Wells, Clinton W. Epps, Pankaj Jaiswal, Brett M. Tyler, Stephen A. Ramsey
Review
Microbiology
Thomas J. Sharpton, Leigh Combrink, Holly K. Arnold, Christopher A. Gaulke, Michael Kent
CURRENT OPINION IN MICROBIOLOGY
(2020)
Article
Food Science & Technology
Yang Zhang, Gerd Bobe, Johana S. Revel, Richard R. Rodrigues, Thomas J. Sharpton, Mary L. Fantacone, Kareem Raslan, Cristobal L. Miranda, Malcolm B. Lowry, Paul R. Blakemore, Andrey Morgun, Natalia Shulzhenko, Claudia S. Maier, Jan F. Stevens, Adrian F. Gombart
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Microbiology
Jessica E. Flannery, Keaton Stagaman, Adam R. Burns, Roxana J. Hickey, Leslie E. Roos, Ryan J. Giuliano, Philip A. Fisher, Thomas J. Sharpton
Article
Multidisciplinary Sciences
Claire E. Couch, Holly K. Arnold, Rachel S. Crowhurst, Anna E. Jolles, Thomas J. Sharpton, Marci F. Witczak, Clinton W. Epps, Brianna R. Beechler
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Isabelle E. Logan, Gerd Bobe, Cristobal L. Miranda, Stephany Vasquez-Perez, Jaewoo Choi, Malcolm B. Lowry, Thomas J. Sharpton, Andrey Morgun, Claudia S. Maier, Jan E. Stevens, Natalia Shulzhenko, Adrian E. Gombart
Article
Microbiology
Sarah G. Nalven, Collin P. Ward, Jerome P. Payet, Rose M. Cory, George W. Kling, Thomas J. Sharpton, Christopher M. Sullivan, Byron C. Crump
ENVIRONMENTAL MICROBIOLOGY
(2020)
Review
Veterinary Sciences
Keaton Stagaman, Thomas J. Sharpton, Karen Guillemin
Article
Fisheries
Russel M. Schaaf, Thomas J. Sharpton, Katrina N. Murray, Andrew D. Kent, Michael L. Kent
JOURNAL OF FISH DISEASES
(2020)
Article
Physiology
Jacob Raber, Andrea Fuentes Anaya, Eileen Ruth S. Torres, Joanne Lee, Sydney Boutros, Dmytro Grygoryev, Austin Hammer, Kristin D. Kasschau, Thomas J. Sharpton, Mitchell S. Turker, Amy Kronenberg
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Carmen P. Wong, Kathy R. Magnusson, Thomas J. Sharpton, Emily Ho
Summary: Age-related zinc loss may contribute to T cell dysfunction and chronic inflammation in the elderly. Inadequate zinc intake could lead to immune dysfunction in older populations and increase the risk of chronic inflammation.
Article
Multidisciplinary Sciences
Richard R. Rodrigues, Manoj Gurung, Zhipeng Li, Manuel Garcia-Jaramillo, Renee Greer, Christopher Gaulke, Franziska Bauchinger, Hyekyoung You, Jacob W. Pederson, Stephany Vasquez-Perez, Kimberly D. White, Briana Frink, Benjamin Philmus, Donald B. Jump, Giorgio Trinchieri, David Berry, Thomas J. Sharpton, Amiran Dzutsev, Andrey Morgun, Natalia Shulzhenko
Summary: The Western diet is a major contributor to diabetes, with gut microbiota playing a crucial role in mediating its effects. Utilizing network analysis, the study identifies two species of Lactobacilli decreased by the Western diet, which improve glucose metabolism and restore hepatic mitochondria function in mice.
NATURE COMMUNICATIONS
(2021)
Article
Toxicology
Thomas J. Sharpton, Alexandra Alexiev, Robyn L. Tanguay
Summary: This study proposes using high-throughput model systems as a complement to traditional techniques for rapid identification of dysbiosis-inducing agents. The zebrafish, a particularly powerful high-throughput model system, has been used to identify potential dysbiosis triggers. By implementing innovative study designs and expanding the methodological toolkit, the potential of this model can be further harnessed.
CURRENT OPINION IN TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Rufa L. Mendez, Cristobal Miranda, Courtney R. Armour, Thomas J. Sharpton, Jan Frederik Stevens, Jung Yeon Kwon
CURRENT DEVELOPMENTS IN NUTRITION
(2020)