Commentary: Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration—A Mass Spectrometry Imaging Study of the Perfused Rat Liver

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

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Metformin does not affect postabsorptive hepatic free fatty acid uptake, oxidation or resecretion in humans: A 3-month placebo-controlled clinical trial in patients with type 2 diabetes and healthy controls

(2018) Lars C. Gormsen et al.   DIABETES OBESITY & METABOLISM

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

(2018) Anila K. Madiraju et al.   NATURE MEDICINE

A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study

(2018) Hyewon Chung et al.   PLoS One

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver

(2018) Giulio Calza et al.   Frontiers in Pharmacology

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Metformin as an Anticancer Agent

(2018) Ales Vancura et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism

(2018) Ahmed Alshawi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Affects Heme Function as a Possible Mechanism of Action

(2018) Xiyan Li et al.   G3-Genes Genomes Genetics

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

(2017) Alena Pecinova et al.   Oxidative Medicine and Cellular Longevity

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

(2016) Adam R. Konopka et al.   Cell Reports

Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial

(2015) Mette Marie H. Christensen et al.   DIABETOLOGIA

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

The Target of Metformin in Type 2 Diabetes

(2014) Ele Ferrannini   NEW ENGLAND JOURNAL OF MEDICINE

Novel Inhibitors of Mitochondrial sn-Glycerol 3-phosphate Dehydrogenase

(2014) Adam L. Orr et al.   PLoS One

A Refined Analysis of Superoxide Production by Mitochondrialsn-Glycerol 3-Phosphate Dehydrogenase

(2012) Adam L. Orr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY