Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy

(2018) Yi Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential

(2018) Stefan Michelfelder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RecQ Helicases Function in Development, DNA Repair, and Gene Targeting inPhyscomitrella patens

(2018) Gertrud Wiedemann et al.   PLANT CELL

Physcomitrella patens, a versatile synthetic biology chassis

(2018) Ralf Reski et al.   PLANT CELL REPORTS

The Physcomitrella patens chromosome-scale assembly reveals moss genome structure and evolution

(2018) Daniel Lang et al.   PLANT JOURNAL

Treatment of experimental C3 Glomerulopathy by human complement factor H produced in glycosylation-optimized Physcomitrella patens

(2017) Karsten Häffner et al.   MOLECULAR IMMUNOLOGY

The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment

(2017) Maartje J. Geerlings et al.   MOLECULAR IMMUNOLOGY

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

(2016) Markus J. Harder et al.   BLOOD

Terminal complexes of the complement system: new structural insights and their relevance to function

(2016) Bryan Paul Morgan et al.   IMMUNOLOGICAL REVIEWS

Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders

(2016) Stefan Michelfelder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment

(2016) G. P. Lomonossoff et al.   SCIENCE

Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015

(2015) Marina Noris et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Moss-made pharmaceuticals: from bench to bedside

(2015) Ralf Reski et al.   PLANT BIOTECHNOLOGY JOURNAL

Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2015) Edwin K.S. Wong et al.   Translational Research

A Comparative Analysis of Recombinant Protein Expression in Different Biofactories: Bacteria, Insect Cells and Plant Systems

(2015) Elisa Gecchele et al.   Jove-Journal of Visualized Experiments

Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases

(2014) Eva Stoger et al.   Annual Review of Plant Biology

Diagnosis and management of complement mediated thrombotic microangiopathies

(2014) Spero R. Cataland et al.   BLOOD REVIEWS

Thirty years of baculovirus-insect cell protein expression: from dark horse to mainstream technology

(2014) M. M. van Oers et al.   JOURNAL OF GENERAL VIROLOGY

Assignment of Saccharide Identities through Analysis of Oxonium Ion Fragmentation Profiles in LC–MS/MS of Glycopeptides

(2014) Adnan Halim et al.   JOURNAL OF PROTEOME RESEARCH

Glyco-engineering for biopharmaceutical production in moss bioreactors

(2014) Eva L. Decker et al.   Frontiers in Plant Science

Reannotation and extended community resources for the genome of the non-seed plant Physcomitrella patens provide insights into the evolution of plant gene structures and functions

(2013) Andreas D Zimmer et al.   BMC GENOMICS

Complement factor H related proteins (CFHRs)

(2013) Christine Skerka et al.   MOLECULAR IMMUNOLOGY

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eculizumab for Dense Deposit Disease and C3 Glomerulonephritis

(2012) A. S. Bomback et al.   Clinical Journal of the American Society of Nephrology

Glycomics, glycoproteomics and the immune system

(2012) Daniel Kolarich et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Moss-based production of asialo-erythropoietin devoid of Lewis A and other plant-typical carbohydrate determinants

(2012) Juliana Parsons et al.   PLANT BIOTECHNOLOGY JOURNAL

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease

(2011) A. Zimran et al.   BLOOD

Glycoprotein production in moss bioreactors

(2011) Eva L. Decker et al.   PLANT CELL REPORTS

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

(2010) Lars G. Fritsche et al.   HUMAN MOLECULAR GENETICS

Production of biologically active recombinant human factor H in Physcomitrella

(2010) Annette Büttner-Mainik et al.   PLANT BIOTECHNOLOGY JOURNAL

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Functional cross-kingdom conservation of mammalian and moss (Physcomitrella patens) transcription, translation and secretion machineries

(2008) Marc Gitzinger et al.   PLANT BIOTECHNOLOGY JOURNAL

Factor H family proteins and human diseases

(2008) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY

Complement factor H related proteins in immune diseases

(2008) Christine Skerka et al.   VACCINE