Article
Multidisciplinary Sciences
Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study found that the immunomodulatory effects of Lactobacillus casei Shirota fermented beverage (LcSFB) depend on the mode of antigen presentation, enhancing immune response in mice injected with OVA, but attenuating it in mice treated with injection plus intranasal administration.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Jicheng Wang, Jiachao Zhang, Wenjun Liu, Heping Zhang, Zhihong Sun
Summary: This study reveals that ingested probiotics alter their transcription patterns to survive and adapt in the human gut, indicating a highly dynamic cross-talk between probiotics and the human gut microbiome.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Fisheries
Jinsong Wang, Zhuoying Zhu, Rui Li, Xichang Wang, Xiangjun Leng, Lanming Chen
Summary: The study found that supplementing probiotics feed can significantly improve the growth performance, gut digestion and absorption, non-specific immune system, and gut bacterial community of Micropterus salmoides. Diets with Lactobacillus casei K17 as the main component can enhance the immune response of Micropterus salmoides, providing a reference for the feed industry.
AQUACULTURE REPORTS
(2021)
Article
Food Science & Technology
Winnie-Pui-Pui Liew, Mohd-Redzwan Sabran, Leslie-Thian-Lung Than, Fauzah Abd-Ghani
Summary: This study investigated the modulation of gut microbiota and proteome in rats exposed to aflatoxin B1 (AFB1) and treated with probiotic Lactobacillus casei Shirota (Lcs). The results showed that Lcs intervention significantly reduced AFB1 biomarkers and alleviated inflammation and abnormal cell growth caused by AFB1.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ren Yan, Kaicen Wang, Qiangqiang Wang, Huiyong Jiang, Yingfeng Lu, Xiaoxiao Chen, Hua Zhang, Xiaoling Su, Yiling Du, Lifeng Chen, Lanjuan Li, Longxian Lv
Summary: The study investigated the effects of Lactobacillus casei strain Shirota (LcS) on acute liver injury (ALI) and its underlying mechanism. Results showed that pretreatment with LcS reduced hepatic and intestinal damage, lowered inflammatory cytokines levels, and modulated gut microbiota, metabolome and transcriptome profiles. These findings indicate the potential therapeutic benefits of LcS in treating liver diseases, especially ALI.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xiaomei Zhang, Shanbin Chen, Ming Zhang, Fazheng Ren, Yimei Ren, Yixuan Li, Ning Liu, Yan Zhang, Qi Zhang, Ran Wang
Summary: This study investigated the effect of Lacticaseibacillus paracasei strain Shirota on constipation and depression symptoms in patients with specific etiology and gut microbiota. The results showed that LcS could alleviate certain symptoms of constipation and depression, regulate intestinal microbiota related to mental illness, and significantly decrease IL-6 levels.
Article
Microbiology
Jennifer J. Dawkins, Jessica R. Allegretti, Travis E. Gibson, Emma McClure, Mary Delaney, Lynn Bry, Georg K. Gerber
Summary: This study conducted a longitudinal analysis of the gut microbiome and metabolome changes in patients with primary Clostridioides difficile infection (CDI). The results showed that metabolomic data can accurately predict the recurrence of CDI, providing important insights for the development of diagnostic tests and treatments.
Article
Biochemistry & Molecular Biology
Xiaodong Yang, Xiaoqin He, Shaoqing Xu, Yi Zhang, Chengjun Mo, Yiqiu Lai, Yanyan Song, Zheng Yan, Penghui Ai, Yiwei Qian, Qin Xiao
Summary: This study investigated the effects of Lacticaseibacillus paracasei supplementation on clinical responses, gut microbiota, and faecal metabolites in PD patients. The study found that although there were no major changes in the global gut microbiome, LcS supplementation had favorable effects in managing constipation and other non-motor symptoms in PD patients.
Article
Nutrition & Dietetics
Wing-Yan Wong, Brandon Dow Chan, Tung-Ting Sham, Magnolia Muk-Lan Lee, Chi-On Chan, Chung-Ting Chau, Daniel Kam-Wah Mok, Yiu-Wa Kwan, William Chi-Shing Tai
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation characterized by altered gut microbiota composition. Probiotic treatment with Lactobacillus casei strain Shirota (LcS) has been shown to ameliorate colitis severity in mice. This study demonstrated that LcS treatment improved intestinal integrity and altered bile acid metabolism, leading to anti-inflammatory effects by stabilizing inhibitor of NF-kappa B alpha (I kappa B alpha) expression and suppressing pro-inflammatory mediators.
FRONTIERS IN NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Lei Yang, Yu Wang, Yun Zhang, Wenwen Li, Shu Jiang, Dawei Qian, Jinao Duan
Summary: Constipation is a common gastrointestinal disease with unclear etiology. The interaction between intestinal flora and the host plays an important role in constipation. The application of multiomics technology can reveal the pathogenesis of constipation and provide new treatment strategies.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Yue Li, Liangjie Zhao, Meiling Hou, Tianlin Gao, Jin Sun, Hao Luo, Fengdan Wang, Feng Zhong, Aiguo Ma, Jing Cai
Summary: This study aimed to investigate the protective effects of Lactobacillus casei on intestinal adverse reactions induced by anti-tuberculosis drugs and its regulation on gut microbiota and short-chain fatty acid metabolism. The results showed that supplementation of Lactobacillus casei increased the proportion of intestinal goblet cells and restored the level of mucin-2. The intervention of Lactobacillus casei also influenced the microbial composition and short-chain fatty acid content in the colon.
Article
Food Science & Technology
Daoyan Wu, Mei Cao, Jie Zhou, Shiying Yan, Jingshan Peng, Zhihao Yu, Andong Zhang, Jialin Wu, Xin Yan, Jian Zhao
Summary: The study found that L. casei T1 has an inhibitory effect on H. pylori growth and can reduce the expression of inflammatory factors induced by the pathogen, thus preventing gastric inflammation and gut microbiota alteration.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Ting Wu, Xueqi Chu, Yuxin Cheng, Shuxin Tang, Daniel Zogona, Siyi Pan, Xiaoyun Xu
Summary: The study found that fermented raspberry juice has a positive regulatory effect on gut microbiota, helping to maintain a healthy gut microbiome. In mouse experiments, different doses of FRJ treatments had varying effects on microbial composition. Overall, fermentation is a potential method for producing plant-based juices and improving host health.
Article
Physiology
Chao Mai, Li Qiu, Yong Zeng, Xingqin Tan
Summary: In this study, it was found that Lactobacillus casei strain Shirota (LcS) enhanced the ability of geniposide to reduce sepsis, inflammation, and oxidative stress by regulating SIRT1 pathway, resulting in decreased inflammatory and oxidative damage in septic mice, similar to the effect of dexamethasone.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Feiyan Zhao, Xiaoye Bai, Juntao Zhang, Lai-Yu Kwok, Lingling Shen, Hao Jin, Tiansong Sun, Zhihong Sun, Heping Zhang
Summary: Bifidobacteria are beneficial gut inhabitants and their responses to probiotic intervention vary depending on subjects' geographic origins.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Jingxuan Wang, Yixuan Li, Liang Zhao, Fazheng Ren, Huiyuan Guo
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Endocrinology & Metabolism
Jing Zhou, Honggui Li, Yuli Cai, Linqiang Ma, Destiny Matthews, Bangchao Lu, Bilian Zhu, Yanming Chen, Xiaoxian Qian, Xiaoqiu Xiao, Qifu Li, Shaodong Guo, Yuqing Huo, Liang Zhao, Yanan Tian, Qingsheng Li, Chaodong Wu
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Ying Liu, Bin Liu, Dan Li, Yulin Hu, Liang Zhao, Ming Zhang, Shaoyang Ge, Jie Pang, Yixuan Li, Ran Wang, Pengjie Wang, Yutao Huang, Jing Huang, Jie Bai, Fazheng Ren, Yuan Li
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Biotechnology & Applied Microbiology
Yuanyuan Dong, Jun Zhu, Ming Zhang, Shaoyang Ge, Liang Zhao
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Endocrinology & Metabolism
Mingjuan Deng, Fang Qu, Long Chen, Chang Liu, Ming Zhang, Fazheng Ren, Huiyuan Guo, Hao Zhang, Shaoyang Ge, Chaodong Wu, Liang Zhao
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Microbiology
Deng Lin, Ran Wang, Junjie Luo, Fazheng Ren, Zhenglong Gu, Yiqiang Zhao, Liang Zhao
Article
Geriatrics & Gerontology
Yichao Hou, Xingqi Li, Chang Liu, Ming Zhang, Xiaoying Zhang, Shaoyang Ge, Liang Zhao
Summary: The study found that sodium butyrate has the most effective alleviation of motor disorder in PD mice and can inhibit neuroinflammation, reducing neurological damage in PD.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Food Science & Technology
Yajie Zheng, Fang Wu, Ming Zhang, Bing Fang, Liang Zhao, Lijie Dong, Xiaojuan Zhou, Shaoyang Ge
Summary: The study found that camel milk supplement has positive effects in reducing blood glucose, cholesterol, and increasing GLP-1, indicating improvement in adipose tissue and skeletal muscle. Camel milk powder can be used as a functional food to treat type 2 diabetes.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Mingjuan Deng, Xingqi Li, Weiwei Li, Jiahui Gong, Xiaoying Zhang, Shaoyang Ge, Liang Zhao
Summary: This study assessed the proapoptotic effects of three major gut-derived PBUTs on hepatocytes, with hippuric acid showing the highest efficacy, and found that propionate significantly reduced apoptosis in liver cells by improving mitochondrial function and reducing oxidative stress. These findings suggest that PBUTs accumulation may contribute to liver dysfunction in CKD patients, and SCFAs supplementation could be a potential protective strategy for CKD patients.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Weiwei Li, Mingjuan Deng, Jiahui Gong, Xiaoying Zhang, Shaoyang Ge, Liang Zhao
Summary: This study revealed that acetate (NaA) effectively inhibited TGF-beta 1-induced activation of LX2 cells by entering the cells and activating the AMPK/PPAR-gamma pathways while blocking the c-Jun signaling pathway.
FRONTIERS IN NUTRITION
(2021)
Article
Food Science & Technology
Fang Wu, Guna Wuri, Bing Fang, Mengxuan Shi, Ming Zhang, Liang Zhao
Summary: This study found that BAA6 alleviated symptoms of ulcerative colitis in a mouse model. It increased levels of butyric acid and activated the butyric acid-FFAR pathway, while suppressing excessive inflammatory response and protecting the function of the colon epithelial barrier.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Li, Mingjuan Deng, Jiahui Gong, Yichao Hou, Liang Zhao
Summary: This study aimed to assess the effect and mechanism of sodium acetate (NaA) on regulating the activity of macrophages. The results showed that low doses of NaA significantly increased inflammatory factors expression and the M1 polarization ratio of macrophages, while high doses of NaA reduced the inflammatory responses. Furthermore, NaA bidirectionally regulated macrophage activity through the PPAR gamma/UCP2/AMPK/iNOS/I kappa B alpha/NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Zhe Sun, Zhi Zhao, Bing Fang, Weilian Hung, Haina Gao, Wen Zhao, Hanglian Lan, Mingkun Liu, Liang Zhao, Ming Zhang
Summary: Inactivation is a crucial step in the production of postbiotics, and excessive heating can diminish the antioxidant activity and alter the chemical composition of postbiotics. However, mild heating does not affect the antioxidant and anti-inflammatory properties of postbiotics. The findings highlight the importance of carefully controlling the heating temperature in the production of postbiotics.
Article
Food Science & Technology
Taojun Wang, Huiyuan Guo, Hao Zhang, Fazheng Ren, Ming Zhang, Shaoyang Ge, Hailing Luo, Liang Zhao
FOOD SCIENCE OF ANIMAL RESOURCES
(2019)