Full restoration of specific infectivity and strain properties from pure mammalian prion protein

Artificial strain of human prions created in vitro

(2018) Chae Kim et al.   Nature Communications

Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates

(2018) Kanchan Phadwal et al.   Scientific Reports

Prion replication environment defines the fate of prion strain adaptation

(2018) Elizaveta Katorcha et al.   PLoS Pathogens

Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPSc

(2018) Fei Wang et al.   Acta Neuropathologica Communications

Endogenous Brain Lipids Inhibit Prion Amyloid Formation In Vitro

(2017) Clare E. Hoover et al.   JOURNAL OF VIROLOGY

Prion replication without host adaptation during interspecies transmissions

(2017) Jifeng Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the key to the resistance of canids to prion diseases

(2017) Natalia Fernández-Borges et al.   PLoS Pathogens

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity

(2017) Fei Wang et al.   PLoS Pathogens

PrPSc formation and clearance as determinants of prion tropism

(2017) Ronald A. Shikiya et al.   PLoS Pathogens

Sialylation Controls Prion Fatein Vivo

(2016) Saurabh Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmissibility of Gerstmann–Sträussler–Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity

(2016) Romolo Nonno et al.   Prion

Cross-species transmission of CWD prions

(2016) Timothy D. Kurt et al.   Prion

Isolation of a Defective Prion Mutant from Natural Scrapie

(2016) Ilaria Vanni et al.   PLoS Pathogens

Requirements for Mutant and Wild-Type Prion Protein Misfolding In Vitro

(2015) Geoffrey P. Noble et al.   BIOCHEMISTRY

Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation

(2015) Clive Bate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Glycosylation Status of PrPCIs a Key Factor in Determining Transmissible Spongiform Encephalopathy Transmission between Species

(2015) Frances K. Wiseman et al.   JOURNAL OF VIROLOGY

A systematic investigation of production of synthetic prions from recombinant prion protein

(2015) Christian Schmidt et al.   Open Biology

Synthetic prions with novel strain-specified properties

(2015) Fabio Moda et al.   PLoS Pathogens

A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers

(2015) Geoffrey P. Noble et al.   PLoS Pathogens

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

(2015) Christina D. Orrú et al.   PLoS Pathogens

Sialylation of the prion protein glycans controls prion replication rate and glycoform ratio

(2015) Elizaveta Katorcha et al.   Scientific Reports

Uptake and Degradation of Protease-Sensitive and -Resistant Forms of Abnormal Human Prion Protein Aggregates by Human Astrocytes

(2014) Young Pyo Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Synthesis of High Titer Infectious Prions with Cofactor Molecules

(2014) Surachai Supattapone   JOURNAL OF BIOLOGICAL CHEMISTRY

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Evidence That Bank Vole PrP Is a Universal Acceptor for Prions

(2014) Joel C. Watts et al.   PLoS Pathogens

Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties

(2013) Enrico Cancellotti et al.   EMBO JOURNAL

Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease

(2013) Xiangzhu Xiao et al.   PLoS One

Chronic Wasting Disease in Bank Voles: Characterisation of the Shortest Incubation Time Model for Prion Diseases

(2013) Michele Angelo Di Bari et al.   PLoS Pathogens

Genesis of tramsmissible protein states via deformed templating

(2012) Natallia Makarava et al.   Prion

Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein

(2012) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rabbits are not resistant to prion infection

(2012) F. Chianini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain

(2012) Sukhvir Paul Mahal et al.   PLoS Pathogens

Effect of Glycans and the Glycophosphatidylinositol Anchor on Strain Dependent Conformations of Scrapie Prion Protein: Improved Purifications and Infrared Spectra

(2011) Gerald S. Baron et al.   BIOCHEMISTRY

Abrogation of Complex Glycosylation by Swainsonine Results in Strain- and Cell-specific Inhibition of Prion Replication

(2011) Shawn Browning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Propagation in Cells Expressing PrP Glycosylation Mutants

(2011) M. K. Salamat et al.   JOURNAL OF VIROLOGY

Spontaneous generation of anchorless prions in transgenic mice

(2011) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultra-Efficient PrPSc Amplification Highlights Potentialities and Pitfalls of PMCA Technology

(2011) Gian Mario Cosseddu et al.   PLoS Pathogens

Dissociation of Infectivity from Seeding Ability in Prions with Alternate Docking Mechanism

(2011) Michael B. Miller et al.   PLoS Pathogens

Recombinant prion protein induces a new transmissible prion disease in wild-type animals

(2010) Natallia Makarava et al.   ACTA NEUROPATHOLOGICA

The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication

(2010) Clive Bate et al.   BIOCHEMICAL JOURNAL

Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors

(2010) Jae-Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein

(2010) M. K. Sandberg et al.   JOURNAL OF GENERAL VIROLOGY

The role of the prion protein membrane anchor in prion infection

(2010) Suzette A. Priola et al.   Prion

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro

(2009) Jae-Il Kim et al.   FEBS LETTERS

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Cells Expressing Anchorless Prion Protein Are Resistant to Scrapie Infection

(2009) K. L. McNally et al.   JOURNAL OF VIROLOGY

Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism

(2009) J. R. Piro et al.   JOURNAL OF VIROLOGY

Crossing the Species Barrier by PrPSc Replication In Vitro Generates Unique Infectious Prions

(2008) Joaquín Castilla et al.   CELL

The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie

(2008) M. A. Di Bari et al.   JOURNAL OF GENERAL VIROLOGY

Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection

(2008) Nadia L Tuzi et al.   PLOS BIOLOGY