RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals

Sorafenib paradoxically activates the RAS/RAF/ERK pathway in polyclonal human NK cells during expansion and thereby enhances effector functions in a dose- and time-dependent manner

(2018) J. Lohmeyer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication

(2018) Julianna Han et al.   Cell Reports

Sorafenib combined with HER-2 targeted vaccination can promote effective T cell immunity in vivo

(2017) Melek M.E. Sunay et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway

(2017) Ashwini Brahms et al.   JOURNAL OF VIROLOGY

The kinase-inhibitor sorafenib inhibits multiple steps of the Hepatitis C Virus infectious cycle in vitro

(2015) Véronique Descamps et al.   ANTIVIRAL RESEARCH

GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases

(2015) Jane L. Roberts et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Importin-α7 as a Therapeutic Approach against Pandemic Influenza Viruses

(2015) Patricia Resa-Infante et al.   JOURNAL OF VIROLOGY

Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection

(2015) Ashwini Benedict et al.   Frontiers in Microbiology

Maraviroc – A CCR5 Antagonist for the Treatment of HIV-1 Infection

(2015) Elna Van Der Ryst   Frontiers in Immunology

In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

(2014) Søren Ottosen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The multi-targeted kinase inhibitor sorafenib inhibits enterovirus 71 replication by regulating IRES-dependent translation of viral proteins

(2014) Meng Gao et al.   ANTIVIRAL RESEARCH

pH-Controlled Two-Step Uncoating of Influenza Virus

(2014) Sai Li et al.   BIOPHYSICAL JOURNAL

Transferrin Receptor-Mediated Endocytosis: A Useful Target for Cancer Therapy

(2014) Stephanie Tortorella et al.   JOURNAL OF MEMBRANE BIOLOGY

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

(2014) O. Perwitasari et al.   JOURNAL OF VIROLOGY

Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom

(2014) R. A. Elderfield et al.   JOURNAL OF VIROLOGY

Stepwise Priming by Acidic pH and a High K+ Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

(2014) S. Stauffer et al.   JOURNAL OF VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

Influenza A virus uses the aggresome processing machinery for host cell entry

(2014) Indranil Banerjee et al.   SCIENCE

Hantavirus Gn and Gc Envelope Glycoproteins: Key Structural Units for Virus Cell Entry and Virus Assembly

(2014) Nicolás Cifuentes-Muñoz et al.   Viruses-Basel

The epidemiology and spread of drug resistant human influenza viruses

(2014) Aeron C Hurt   Current Opinion in Virology

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

A Phase I Dose-Escalation Study of Regorafenib (BAY 73-4506), an Inhibitor of Oncogenic, Angiogenic, and Stromal Kinases, in Patients with Advanced Solid Tumors

(2012) K. Mross et al.   CLINICAL CANCER RESEARCH

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

cSSMD: assessing collective activity for addressing off-target effects in genome-scale RNA interference screens

(2011) Xiaohua Douglas Zhang et al.   BIOINFORMATICS

Inhibition of Influenza Virus Activity by Multivalent Glycoarchitectures with Matched Sizes

(2011) Ilona Papp et al.   CHEMBIOCHEM

Cancer Patients Treated with Sunitinib or Sorafenib Have Sufficient Antibody and Cellular Immune Responses to Warrant Influenza Vaccination

(2011) S. F. Mulder et al.   CLINICAL CANCER RESEARCH

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo

(2011) K. L. Roberts et al.   JOURNAL OF GENERAL VIROLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

The host interactome of influenza virus presents new potential targets for antiviral drugs

(2011) Megan L. Shaw   REVIEWS IN MEDICAL VIROLOGY

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

(2011) Erik de Vries et al.   PLoS Pathogens

Viral Drug Sensitivity Testing Using Quantitative PCR: Table 1

(2010) Parmjeet S. Randhawa et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Cellular Networks Involved in the Influenza Virus Life Cycle

(2010) Tokiko Watanabe et al.   Cell Host & Microbe

The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication

(2010) Martin Michaelis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

(2010) Scott M. Wilhelm et al.   INTERNATIONAL JOURNAL OF CANCER

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181

(2010) Gallen B. Triana-Baltzer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

PKA Regulates Vacuolar H+-ATPase Localization and Activity via Direct Phosphorylation of the A Subunit in Kidney Cells

(2010) Rodrigo Alzamora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state

(2010) C. Seitz et al.   JOURNAL OF GENERAL VIROLOGY

Emerging Influenza Antiviral Resistance Threats

(2010) F. G. Hayden et al.   JOURNAL OF INFECTIOUS DISEASES

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Endocytosis of Chikungunya Virus into Mammalian Cells: Role of Clathrin and Early Endosomal Compartments

(2010) Eric Bernard et al.   PLoS One

Comparative Pathology of Select Agent Influenza A Virus Infections

(2010) T. Kuiken et al.   VETERINARY PATHOLOGY

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells

(2010) Thorsten Eierhoff et al.   PLoS Pathogens

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes

(2009) C Alfaro et al.   BRITISH JOURNAL OF CANCER

The Influenza Virus Enigma

(2009) Rachelle Salomon et al.   CELL

Influenza B mutant viruses with truncated NS1 proteins grow efficiently in Vero cells and are immunogenic in mice

(2009) N. Wressnigg et al.   JOURNAL OF GENERAL VIROLOGY

The Kinase Inhibitors Sunitinib and Sorafenib Differentially Affect NK Cell Antitumor Reactivity In Vitro

(2009) M. Krusch et al.   JOURNAL OF IMMUNOLOGY

Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation

(2009) A. C. Hurt et al.   JOURNAL OF VIROLOGY

Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses

(2008) M. M. Hipp et al.   BLOOD

Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation

(2008) W Zhao et al.   LEUKEMIA

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH