Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS

Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site

(2017) Morgan M. Fetherolf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

(2017) Enrico Luchinat et al.   Scientific Reports

A faulty interaction between SOD1 and hCCS in neurodegenerative disease

(2016) Gareth S. A. Wright et al.   Scientific Reports

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations

(2015) Liangzhong Lim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro

(2015) Svenja Petzoldt et al.   BIOMETALS

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

(2015) Elizabeth A. Proctor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense

(2014) J. E. Gleason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-associated aggregate formation of superoxide dismutase-1 is initiated by membrane-targeting loops

(2014) Choon-Peng Chng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants

(2014) Enrico Luchinat et al.   Nature Communications

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1

(2013) Edward B. Maryon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Atox1 Contains Positive Residues that Mediate Membrane Association and Aid Subsequent Copper Loading

(2013) Adrian G. Flores et al.   JOURNAL OF MEMBRANE BIOLOGY

The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation

(2013) Gareth S. A. Wright et al.   JOURNAL OF SYNCHROTRON RADIATION

Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes

(2013) C. R. Pope et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand binding and aggregation of pathogenic SOD1

(2013) Gareth S.A. Wright et al.   Nature Communications

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

(2013) Luke McAlary et al.   Scientific Reports

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

(2012) S. J. Weisberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)

(2012) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies

(2011) Gareth S. A. Wright et al.   BIOCHEMICAL JOURNAL

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Folding Catalysis by Transient Coordination of Zn2+to the Cu Ligands of the ALS-Associated Enzyme Cu/Zn Superoxide Dismutase 1

(2010) Lina Leinartaitė et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hitchhiking of Cu/Zn Superoxide Dismutase to Peroxisomes - Evidence for a Natural Piggyback Import Mechanism in Mammals

(2009) Markus Islinger et al.   TRAFFIC

Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS

(2008) Jody B. Proescher et al.   HUMAN MOLECULAR GENETICS

Instability of Superoxide Dismutase 1 ofDrosophilain Mutants Deficient for Its Cognate Copper Chaperone

(2008) Kim Kirby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY