Embryonic stem cells become mechanoresponsive upon exit from ground state of pluripotency

Scaffold Stiffness at Microscale Directs Stem Cell Lineage Specification

(2018) Yang Song et al.   BIOPHYSICAL JOURNAL

Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms

(2018) Nils C Gauthier et al.   CURRENT OPINION IN CELL BIOLOGY

Pluripotency Deconstructed

(2018) Masaki Kinoshita et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Reciprocal link between cell biomechanics and exocytosis

(2018) Guan Wang et al.   TRAFFIC

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

(2017) Maxwell Z. Wilson et al.   MOLECULAR CELL

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A 3D magnetic tissue stretcher for remote mechanical control of embryonic stem cell differentiation

(2017) Vicard Du et al.   Nature Communications

Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells

(2016) Nobuhiro Kushida et al.   BMC Urology

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

(2016) Masato Morikawa et al.   Stem Cell Reports

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography

(2014) Dongyuan Lü et al.   BIOMATERIALS

Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

(2014) Yue Shao et al.   Integrative Biology

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

(2014) Thorsten Boroviak et al.   NATURE CELL BIOLOGY

Auxetic nuclei in embryonic stem cells exiting pluripotency

(2014) Stefano Pagliara et al.   NATURE MATERIALS

Defining an essential transcription factor program for naive pluripotency

(2014) S.- J. Dunn et al.   SCIENCE

A polymeric cell stretching device for real-time imaging with optical microscopy

(2013) Yuli Huang et al.   BIOMEDICAL MICRODEVICES

Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions

(2013) Yue Shao et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

(2012) Hendrik Marks et al.   CELL

Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells

(2012) Geoffrey C. Hunt et al.   EXPERIMENTAL CELL RESEARCH

Effects of shear stress on germ lineage specification of embryonic stem cells

(2012) Russell P. Wolfe et al.   Integrative Biology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells

(2011) Takeshi Teramura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signal Transduction of Pregnenolone Sulfate in Insulinoma Cells

(2011) Sabine I. Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Primary Response Genes

(2011) Trent Fowler et al.   MOLECULAR CELL

External forces control mitotic spindle positioning

(2011) Jenny Fink et al.   NATURE CELL BIOLOGY

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

(2011) Jason Wray et al.   NATURE CELL BIOLOGY

Egr-1—A Ca2+-regulated transcription factor

(2010) Gerald Thiel et al.   CELL CALCIUM

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells

(2010) Yun Feng Rui et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE