Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc
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Title
Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc
Authors
Keywords
Lysosome, cAMP, Zinc, MT3, EALP
Journal
Molecular Brain
Volume 12, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-03-14
DOI
10.1186/s13041-019-0439-2
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Note: Only part of the references are listed.- Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation
- (2018) Ying Wang et al. NEUROTOXICITY RESEARCH
- The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice
- (2018) Valerio Frazzini et al. Scientific Reports
- A role for autophagy in Huntington's disease
- (2018) Katherine R. Croce et al. NEUROBIOLOGY OF DISEASE
- Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
- (2018) Paola Rusmini et al. Autophagy
- Neurological effects of glucocerebrosidase gene mutations
- (2018) S. Mullin et al. EUROPEAN JOURNAL OF NEUROLOGY
- Copper and Zinc Dysregulation in Alzheimer’s Disease
- (2018) Stefano L. Sensi et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics
- (2017) Anna Chiara Nascimbeni et al. FEBS Journal
- Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways
- (2017) Johan-Owen De Craene et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Zinc transporter 2 interacts with vacuolar ATPase and is required for polarization, vesicle acidification, and secretion in mammary epithelial cells
- (2017) Sooyeon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
- (2017) Tim E. Moors et al. Molecular Neurodegeneration
- Not just amyloid: physiological functions of the amyloid precursor protein family
- (2017) Ulrike C. Müller et al. NATURE REVIEWS NEUROSCIENCE
- PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes
- (2017) Christin Bissig et al. TRAFFIC
- Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency
- (2017) Bret M. Evers et al. Cell Reports
- Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells
- (2017) Xingzhi Guo et al. Frontiers in Aging Neuroscience
- The crucial impact of lysosomes in aging and longevity
- (2016) Didac Carmona-Gutierrez et al. AGEING RESEARCH REVIEWS
- Lysosomal cathepsins and their regulation in aging and neurodegeneration
- (2016) Veronika Stoka et al. AGEING RESEARCH REVIEWS
- Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases
- (2016) Mathieu Bourdenx et al. Autophagy
- Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity
- (2016) Kyle M. Trudeau et al. JOURNAL OF CELL BIOLOGY
- Soluble adenylyl cyclase is essential for proper lysosomal acidification
- (2016) Nawreen Rahman et al. JOURNAL OF GENERAL PHYSIOLOGY
- Autophagy in motor neuron disease: Key pathogenetic mechanisms and therapeutic targets
- (2016) Maria Sara Cipolat Mis et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
- (2016) Deepak Kumar Vijaya Kumar et al. Science Translational Medicine
- Lysosomal Physiology
- (2015) Haoxing Xu et al. Annual Review of Physiology
- Lysosomal calcium regulates autophagy
- (2015) Diego L Medina et al. Autophagy
- The role of TRPMLs in endolysosomal trafficking and function
- (2015) Kartik Venkatachalam et al. CELL CALCIUM
- TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion
- (2015) Q. Xia et al. EMBO JOURNAL
- Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A Generation and Amyloid Plaque Pathogenesis
- (2015) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial
- (2015) LANCET NEUROLOGY
- The endosomal pathway in Parkinson's disease
- (2015) Rebecca M. Perrett et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling
- (2015) Natura Myeku et al. NATURE MEDICINE
- The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP/mutant presenilin-1–transfected Chinese hamster ovary cells
- (2015) Bo-Ra Seo et al. NEUROBIOLOGY OF AGING
- Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse
- (2015) Peng Lei et al. NEUROBIOLOGY OF DISEASE
- The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism
- (2015) Taiho Kambe et al. PHYSIOLOGICAL REVIEWS
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization
- (2015) Sook-Jeong Lee et al. Molecular Brain
- Zinc and autophagy
- (2014) Juan P. Liuzzi et al. BIOMETALS
- Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
- (2014) V. A. Polito et al. EMBO Molecular Medicine
- Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
- (2014) Stephanie M.Y. Kong et al. HUMAN MOLECULAR GENETICS
- Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction
- (2014) Jin-Sung Park et al. HUMAN MOLECULAR GENETICS
- Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
- (2014) Huihui Han et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP
- (2014) E.E. Coffey et al. NEUROSCIENCE
- Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition
- (2014) A. Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
- (2013) Devin M. Wolfe et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation
- (2013) Taiji Tsunemi et al. HUMAN MOLECULAR GENETICS
- ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy
- (2013) Santosh Chauhan et al. MOLECULAR CELL
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Signals from the lysosome: a control centre for cellular clearance and energy metabolism
- (2013) Carmine Settembre et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development
- (2013) Qing Ouyang et al. NEURON
- Osteopetrosis Mutation R444L Causes Endoplasmic Reticulum Retention and Misprocessing of Vacuolar H+-ATPasea3Subunit
- (2012) Ajay Bhargava et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The retromer complex - endosomal protein recycling and beyond
- (2012) M. N. J. Seaman JOURNAL OF CELL SCIENCE
- Cytosolic acidification and intracellular zinc release in hippocampal neurons
- (2012) Lech Kiedrowski JOURNAL OF NEUROCHEMISTRY
- Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation
- (2012) Yueguang Rong et al. NATURE CELL BIOLOGY
- Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
- (2011) Raquel Sanchez-Varo et al. ACTA NEUROPATHOLOGICA
- Pairing phosphoinositides with calcium ions in endolysosomal dynamics
- (2011) Dongbiao Shen et al. BIOESSAYS
- Autophagy Dysregulation in Amyotrophic Lateral Sclerosis
- (2011) Sheng Chen et al. BRAIN PATHOLOGY
- Role of Zinc Metallothionein-3 (ZnMt3) in Epidermal Growth Factor (EGF)-induced c-Abl Protein Activation and Actin Polymerization in Cultured Astrocytes
- (2011) Sook-Jeong Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy
- (2011) S. Lee et al. JOURNAL OF NEUROSCIENCE
- Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore
- (2011) Mi-Ha Park et al. NEUROBIOLOGY OF DISEASE
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Laforin, the most common protein mutated in Lafora disease, regulates autophagy
- (2010) Carmen Aguado et al. HUMAN MOLECULAR GENETICS
- Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel
- (2010) Jonathan L. Eichelsdoerfer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Termination of autophagy and reformation of lysosomes regulated by mTOR
- (2010) Li Yu et al. NATURE
- Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction
- (2010) C Corona et al. Cell Death & Disease
- Aging: Central role for autophagy and the lysosomal degradative system
- (2009) Yogendra S. Rajawat et al. AGEING RESEARCH REVIEWS
- Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
- (2009) Paul Saftig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A Gene Network Regulating Lysosomal Biogenesis and Function
- (2009) Marco Sardiello et al. SCIENCE
- Sorting of lysosomal proteins
- (2008) Thomas Braulke et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Principles of lysosomal membrane degradation
- (2008) Heike Schulze et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes
- (2008) Shunsuke Kimura et al. CELL STRUCTURE AND FUNCTION
- Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
- (2008) Tadanori Hamano et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
- (2008) Paul A. Adlard et al. NEURON
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